Amphofic Injection
Prescription Required
Product introduction
Amphofic Injection is an antifungal medication. It is used in the treatment of severe fungal infections and kala-azar. It kills the infection causing fungi and thus, treats the infection.
Amphofic Injection is administered as an injection by a healthcare professional. Kindly do not self administer. Before you take this medicine, inform your doctor if you suffer from diabetes, liver/kidney problems or are on dialysis or have low potassium level in blood.
It may lead to a few common side effects like headache, vomiting, nausea, stomach cramps and fever. You may also notice some injection site reactions like pain, swelling or redness. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.
Amphofic Injection is administered as an injection by a healthcare professional. Kindly do not self administer. Before you take this medicine, inform your doctor if you suffer from diabetes, liver/kidney problems or are on dialysis or have low potassium level in blood.
It may lead to a few common side effects like headache, vomiting, nausea, stomach cramps and fever. You may also notice some injection site reactions like pain, swelling or redness. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.
Uses of Amphofic Injection
- Severe fungal infections
- Kala-azar
Benefits of Amphofic Injection
In Severe fungal infections
Amphofic Injection works by killing the fungi which can cause serious infections. It is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the fungi and yeast causing the infection are killed and do not become resistant.
In Kala-azar
Kala azar is a disease caused by leishmania parasites mainly by the bite of infected sandflies. Amphofic Injection helps to kill the infection causing parasites and helps to treat the infection. This medicine is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the parasites are killed and do not become resistant.
Side effects of Amphofic Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Amphofic
- Injection site reactions (pain, swelling, redness)
- Nausea
- Vomiting
- Chills
- Headache
- Anemia (low number of red blood cells)
- Decreased potassium level in blood
- Abnormal liver function tests
- Decreased magnesium level in blood
- Diarrhea
- Decreased appetite
- Hypotension (low blood pressure)
- Skin rash
- Nephrocalcinosis
- Increased creatinine level in blood
- Abnormal renal function tests
- Renal tubular acidosis
How to use Amphofic Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Amphofic Injection works
Amphofic Injection is an antifungal medication. It kills fungi by destroying the fungal cell membrane.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Amphofic Injection. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Amphofic Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
CONSULT YOUR DOCTOR
Amphofic Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Amphofic Injection may cause side effects which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Amphofic Injection is safe to use in patients with kidney disease. No dose adjustment of Amphofic Injection is recommended.
However, inform your doctor if you have any underlying kidney disease.
However, inform your doctor if you have any underlying kidney disease.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Amphofic Injection in patients with liver disease. Please consult your doctor.
What if you forget to take Amphofic Injection?
If you miss a dose of Amphofic Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- It is usually given as an injection over 1-2 hours under the supervision of a medical professional.
- Amphofic Injection can cause rash, chills, headache, and tiredness during initial days of the treatment, but these may fade away with time.
- Your doctor may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium and kidney function.
- Inform your doctor immediately if you notice pain or blood upon urination, swelling of the face and trouble breathing.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Fact Box
Chemical Class
Aminoglycosides {Polyenes}
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Action Class
Fungal cell membrane active agent
Interaction with drugs
Taking Amphofic with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may cause damage to the kidneys and decreased production of cells responsible for providing immunity, carrying oxygen, and/or those responsible for normal blood clot
Concurrent use may increase the risk of kidney dysfunction.
Your doctor may monitor your kidney function regularly.
Concurrent use may increase the risk of kidney damage.
Do not consume Tenofovir disoproxil fumarate with Amphotericin B. If concurrent use is essential, your doctor may monitor yo
Concurrent use may potentially damage the kidneys.
If concurrent use is essential, your doctor may closely monitor your kidney's functioning and overall treatment.
Concurrent use may increase the risk of kidney impairment.
If concurrent use is essential, your doctor may closely monitor your kidney's functioning and overall treatment.
Patient concerns
FAQs
Is Amphofic Injection fungistatic or fungicidal?
Amphofic Injection is fungicidal in nature, it acts by killing the fungus
Is Amphofic Injection light sensitive?
Amphofic Injection is not light sensitive
What is Amphofic Injection liposomal?
Liposomal Amphofic Injection is a lipid-associated formulation. Liposomal encapsulation or incorporation into a lipid complex of Amphofic Injection can substantially improves drug safety especially nephrotoxicity associated with the drug
Is Amphofic Injection an antibiotic?
Yes, Amphofic Injection is an antifungal antibiotic for the treatment of serious infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells [neutrophils]) and Visceral leishmaniasis (disease caused by a parasite)
Is Amphofic Injection testing dose needed?
Yes, administration of Amphofic Injection is associated with allergy (severe and serious allergic) reaction, therefore it is recommended to administer a test dose before starting the therapy to check for sensitivity
How is Amphofic Injection administered?
Amphofic Injection is either administered as intravenous injection or infusion by a registered medical professional only
How does Amphofic Injection cause nephrotoxicity and hyperkalemia?
Amphofic Injection can disrupt the lipid components of human kidney cells, thereby causing nephrotoxicity. The exact mechanism of hypokalemia is not known, but kidney damage may result in excessive loss of potassium in urine.
Want to share the information?
Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1424.
- Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1571-75.
- Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 836-38.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 68-69.
- Medsacpe. Amphotericin. [Accessed 29 Mar. 2019] (online) Available from:
- Amphotericin B. San Dimas, California: Gilead Sciences, Inc.; 2000. [Accessed 04 Feb. 2019] (online) Available from:
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. Jornal de Pediatria. 2004; 80(5):4-6. [Accessed 29 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:
Marketer details
Name: Gufic Bioscience Ltd
Address: 37,1st Floor, Kamala Bhavan II, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (INDIA)
Country of origin: India
Lab tests offered by us
Related/Popular tests
₹3556
Inclusive of all taxes
MRP₹3700 4% OFF
1.0 Injection in 1 vial
SOLD OUT
Notify me
