Amitriptyline Hcl 25mg Tablet
Product introduction
Amitriptyline Hcl 25mg Tablet is a medicine used to treat depression by helping improve mood and reduce anxiety. It works by restoring the natural balance of certain brain chemicals that affect emotions. This helps relieve sadness, improves mental well-being, and makes daily life easier to manage.
Amitriptyline Hcl 25mg Tablet is normally taken before bedtime because it can make you sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms.
How long you need to use it will depend on what you are taking it for, but it is important to continue taking this medication even if you feel well. Do not stop taking the medicine suddenly without talking to your doctor. Stopping the medicine suddenly can worsen your condition or cause other symptoms. Your dose may be modified or gradually decreased before stopping the medication.
The most common side effects of this medicine include constipation, dry mouth, sleepiness, dizziness, and headache. It may also make you aggressive or confused, and can cause weight gain in some people.
This medicine is not addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.
Uses of Amitriptyline Tablet
Benefits of Amitriptyline Tablet
In Treatment of Depression
Amitriptyline Hcl 25mg Tablet helps relieve symptoms of depression by increasing the levels of certain mood-regulating chemicals, such as serotonin and norepinephrine, in the brain. It improves mood, reduces feelings of sadness or hopelessness, and improves sleep quality. When use consistently as prescribed by the doctor, it can significantly improve a patient’s daily functioning and overall quality of life.
Side effects of Amitriptyline Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Amitriptyline
- Constipation
- Dryness in mouth
- Sleepiness
- Dizziness
- Headache
- Fatigue
- Confusion
How to use Amitriptyline Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amitriptyline Hcl 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Amitriptyline Tablet works
Amitriptyline Hcl 25mg Tablet contains amitriptyline, an antidepressant (tricyclic antidepressant) that helps overcome depression. It works by increasing certain natural brain chemicals (serotonin and noradrenaline) that improve mood and reduce anxiety. This helps relieve depression and stabilize emotions.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Amitriptyline Hcl 25mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Amitriptyline Hcl 25mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Amitriptyline Hcl 25mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Amitriptyline Hcl 25mg Tablet may cause side effects which could affect your ability to drive.
Amitriptyline Hcl 25mg Tablet may impair your alertness which may affect your ability to drive.
Amitriptyline Hcl 25mg Tablet may impair your alertness which may affect your ability to drive.
Kidney
CAUTION
Amitriptyline Hcl 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Amitriptyline Hcl 25mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Amitriptyline Hcl 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Amitriptyline Hcl 25mg Tablet may be needed. Please consult your doctor.
Use of Amitriptyline Hcl 25mg Tablet is not recommended in patients with severe liver disease.
Use of Amitriptyline Hcl 25mg Tablet is not recommended in patients with severe liver disease.
What if you forget to take Amitriptyline Tablet?
If you miss a dose of Amitriptyline Hcl 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Amitriptyline Hcl 25mg Tablet may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Amitriptyline Hcl 25mg Tablet, as it may cause excessive sleepiness.
- Monitor your weight during the treatment, as this medicine can cause weight gain and increased appetite.
- It may cause a sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
Fact Box
Chemical Class
Dibenzocycloheptenes Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Tricyclic Antidepressants (TCAs)
Interaction with drugs
Taking Amitriptyline with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Tranylcypromine with Amitriptyline. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Amitriptyline. Please consult your doctor.
Do not consume Moclobemide with Amitriptyline. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Amitriptyline. Please consult your doctor.
Concomita
Do not consume Domperidone with Amitriptyline.
Concomitant use may affect heart rhythm.
Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory impairment, tremors, fever, diarrhea, or agitatio
If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, weight gain, constipation, muscle stiffness or tremors and consu
Patient concerns
User feedback
What are you using Amitriptyline Tablet for?
Neuropathic p*
65%
Others
18%
Depression
15%
Migraine
3%
*Neuropathic pain
How much was the improvement?
Excellent
38%
Poor
33%
Average
29%
What were the side-effects while using Amitriptyline Hcl 25mg Tablet?
No Side Effec*
38%
Dryness in mo*
25%
Increased hea*
12%
Sleepiness
12%
Constipation
12%
*No Side Effect, Dryness in mouth, Increased heart rate
How do you take Amitriptyline Tablet?
With food
67%
With or witho*
33%
*With or without food
Please rate Amitriptyline Hcl 25mg Tablet on price
Not Expensive
53%
Average
33%
Expensive
13%
FAQs
What other lifestyle changes should I make to get maximum benefit of Amitriptyline Hcl 25mg Tablet?
Antidepressants, including Amitriptyline Hcl 25mg Tablet, are just one of several approaches to treat depression. Certain lifestyle changes can help you get the maximum benefit from Amitriptyline Hcl 25mg Tablet and help you recover fast. Keeping active and eating a healthy diet can make a significant difference in how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption, as these will only worsen your depression. Take your medicines as prescribed, even if you start feeling better.
Is there anything I need to be careful about while on therapy with Amitriptyline Hcl 25mg Tablet?
Amitriptyline Hcl 25mg Tablet may cause drowsiness and dizziness, especially at the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine, as it might increase sleepiness.
Can the use of Amitriptyline Hcl 25mg Tablet affect my sex life?
Yes, Amitriptyline Hcl 25mg Tablet can affect sex life in both men and women. It may cause decreased sexual desire, or you may experience discomfort during intercourse. Men may experience an inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine and consult your doctor.
I have been taking Amitriptyline Hcl 25mg Tablet for depression for a week, and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?
You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Amitriptyline Hcl 25mg Tablet takes about 2 weeks to show its effect, but it may take longer. Therefore, when you start taking Amitriptyline Hcl 25mg Tablet, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.
Does Amitriptyline Hcl 25mg Tablet cause any effect on pregnancy or the newborn?
Do not take Amitriptyline Hcl 25mg Tablet during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor feeding, loud crying, difficulty in urinating, and constipation.
How will Amitriptyline Hcl 25mg Tablet make me feel?
Antidepressants like Amitriptyline Hcl 25mg Tablet help gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Amitriptyline Hcl 25mg Tablet will not make you feel excessively or unusually happy. It will help you feel like yourself again.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
- Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
- Amitriptyline Hydrochloride [Drug Label]. Ahmedabad, Gujarat: Intas Pharmaceuticals Limited; 2016. [Accessed 25 Jul. 2024] (online) Available from:
- Amitriptylin [Patient Information]. Versus Arthritis;. [Accessed 17 Mar. 2025] (online) Available from:
- Amitriptyline Hydrochloride [Drug Label]. Ahmedabad, Gujarat: Intas Pharmaceuticals Limited; 2025. [Accessed 17 Mar. 2025] (online) Available from:
Marketer details
Name: Densa Pharmaceuticals Pvt Ltd
Address: 1, Anurag Mansion, Shiv-Vallabh Road, Dahisar (E), Mumbai-400068.
Country of origin: India
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10.0 tablets in 1 strip
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