
ASCA - IgG antibody









The ASCA - IgG antibody test is a blood test that detects IgG antibodies against Saccharomyces cerevisiae, a type of yeast present in the digestive tract. This test helps differentiate between inflammatory bowel diseases (IBD), particularly Crohn’s disease and ulcerative colitis.












Understanding ASCA - IgG antibody
Saccharomyces cerevisiae is a normally harmless yeast found in the body and the environment. In some people, however, the immune system reacts by producing antibodies against it. These antibodies, known as anti-Saccharomyces cerevisiae antibodies (ASCA), are commonly linked with Crohn’s disease. Detecting ASCA-IgG in the blood helps differentiate Crohn’s disease from ulcerative colitis. While both conditions fall under the category of IBD, they affect different regions of the gastrointestinal tract and often require distinct treatment approaches.
The ASCA - IgG antibody test is recommended for individuals showing gastrointestinal symptoms such as persistent diarrhea, abdominal pain, weight loss, or rectal bleeding, especially when the clinical features do not clearly point towards either ulcerative colitis or Crohn’s disease. It is also valuable in cases with atypical or overlapping IBD symptoms where additional diagnostic information is needed. By identifying elevated ASCA-IgG levels, clinicians can tailor treatment more precisely to the patient’s condition.
No special preparation is needed for getting the ASCA - IgG antibody test done. However, be sure to inform the doctor about any medications or supplements being taken, as they may affect the test results.
Lab test results may vary across different laboratories. Abnormal test results require expert interpretation. Therefore, never try to self-medicate based solely on these results. Always consult a doctor for a proper understanding of the test resul
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does ASCA - IgG antibody measure?
The ASCA - IgG antibody test detects the presence of IgG antibodies produced by the immune system in response to Saccharomyces cerevisiae. These antibodies are usually present at very low levels in healthy individuals. Elevated IgG antibody levels suggest an abnormal immune reaction to yeast antigens, which is strongly associated with Crohn’s disease. While a positive result does not confirm the disease on its own, it provides supportive evidence when correlated with clinical signs and other laboratory tests. This test does not diagnose ulcerative colitis but can help differentiate between Crohn’s disease and ulcerative colitis, as ASCA positivity is far more common in Crohn’s disease.





FAQs related to ASCA - IgG antibody
- Ashorn S, Raukola H, Välineva T, Ashorn M, Wei B, Braun J, Rantala I, Kaukinen K, Luukkaala T, Collin P, Mäki M, Iltanen S. Elevated serum anti-Saccharomyces cerevisiae, anti-I2 and anti-OmpW antibody levels in patients with suspicion of celiac disease. J Clin Immunol. 2008 Sep;28(5):486-94. [Accessed 19 Sep. 2025]. Available from:
- From ASCA breakthrough in Crohn's disease and Candida albicans research to thirty years of investigations about their meaning in human health [Internet]. ScienceDirect; [Accessed 19 Sep. 2025]. Available from:
- Walker LJ, Aldhous MC, Drummond HE, Smith BR, Nimmo ER, Arnott ID, Satsangi J. Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations. Clin Exp Immunol. 2004 Mar;135(3):490-6. [Accessed 19 Sep. 2025]. Available from:
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