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EMPRogest 8% Vaginal gel is prescribed to prevent miscarriage in women who experience vaginal bleeding in the first trimester and have a history of recurrent miscarriages. It supports early pregnancy by maintaining the uterine lining and creating a stable environment for the developing embryo.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 22 Jan 2026 | 03:53 PM (IST)
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1.125 gm Vaginal gel
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The content is shown in English
EMPRogest 8% Vaginal gel image
EMPRogest 8% Vaginal gel image
EMPRogest 8% Vaginal gel image
EMPRogest 8% Vaginal gel image
EMPRogest 8% Vaginal gel image

Product introduction

EMPRogest 8% Vaginal gel should be inserted deep into the vagina exactly as prescribed. Use the medicine regularly and at the same time each day to maintain consistent support during early pregnancy. Treatment should always be guided by a doctor, and any ongoing bleeding or new symptoms should be reported promptly, as further evaluation may be required.


Most women tolerate EMPRogest 8% Vaginal gel well. Rarely, local side effects such as mild vaginal irritation, itching, burning sensation, or oily discharge may occur. These effects are usually mild and short-lived. If symptoms become bothersome or persistent, consult your doctor.


EMPRogest 8% Vaginal gel should be used only during the first trimester for the prevention of miscarriage. Any vaginal bleeding should always be investigated before and during treatment. The medicine should not be used in women with undiagnosed vaginal bleeding, severe liver disease, hormone-dependent cancers, thromboembolic disorders, or known allergy to progesterone or any ingredient in the product.

Uses of EMPRogest Vaginal gel

  • Prevention of Miscarriage

Benefits of EMPRogest Vaginal gel

Prevention of Miscarriage
EMPRogest 8% Vaginal gel helps in the prevention of miscarriage, especially in women who experience bleeding in early pregnancy and have a history of recurrent pregnancy loss. It supports the pregnancy by maintaining the uterine lining, helping the womb stay relaxed, and creating a favourable environment for the developing embryo. Vaginal administration delivers progesterone directly to the uterus, ensuring effective local action with lower exposure to the rest of the body. This helps improve the chances of continuing the pregnancy and provides reassurance and stability during a critical early phase of pregnancy.

Side effects of EMPRogest Vaginal gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of EMPRogest
  • No common side effects seen

How to use EMPRogest Vaginal gel

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying

How EMPRogest Vaginal gel works

EMPRogest 8% Vaginal gel supports early pregnancy by acting on the uterus to maintain a healthy uterine lining needed for pregnancy to continue. It helps relax the uterine muscles, improves blood flow between the uterus and placenta, and reduces inflammatory and immune responses that could threaten the pregnancy.

Quick tips

  • Insert EMPRogest 8% Vaginal gel deep into the vagina while lying down, preferably at bedtime, to reduce leakage and help the medicine stay in place longer.
  • Use the medicine at regular times every day to maintain consistent hormonal support during early pregnancy.
  • Avoid skipping doses, especially during the first trimester, as this is a crucial period for supporting pregnancy.
  • Inform your doctor immediately if vaginal bleeding increases, becomes painful, or is accompanied by cramps or fever.
  • Avoid using other vaginal products such as douches, creams, or pessaries unless specifically prescribed, as they may interfere with treatment.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
EMPRogest 8% Vaginal gel is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
Breast feeding

Breast feeding

UNSAFE
EMPRogest 8% Vaginal gel is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking EMPRogest with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tamoxifen (Oral Route)

Avoid concurrent use. Please consult with your doctor.
Severe

Letrozole (Oral Route)

Avoid concurrent use. Please consult with your doctor.
Severe

Anastrozole (Oral Route)

Avoid concurrent use. Please consult with your doctor.
Severe

Darunavir (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection.
Severe

Mycophenolate mofetil (Oral Route)

Effective contraception must be used before, during, and for at least 6 weeks after stopping Mycophenolate mofetil. It is recommended to consult your doctor. Mycophenolate mofetil may reduce the efficacy of Progesterone (Natural Micronized).

Frequently asked questions

EMPRogest 8% Vaginal gel is prescribed for women who experience bleeding in early pregnancy and have a history of recurrent miscarriages. It is not intended for routine use in all pregnancies and should only be taken when advised by a doctor.
Treatment is usually started in the first trimester, often at the first sign of vaginal bleeding, and continued up to the 16th week of pregnancy, depending on medical advice.
EMPRogest 8% Vaginal gel helps maintain the uterine lining, keeps the uterus relaxed, and supports a stable environment for the developing embryo. Vaginal use allows the hormone to act directly on the uterus with lower exposure to the rest of the body.
Yes. A mild oily or whitish vaginal discharge is common with EMPRogest 8% Vaginal gel and usually does not mean the medicine is not working. A panty liner may be used for comfort.
No. You should not stop the medicine on your own, even if bleeding improves. EMPRogest 8% Vaginal gel should be continued for the recommended duration to provide ongoing pregnancy support. Always follow your doctor’s advice before stopping.
EMPRogest 8% Vaginal gel does not prevent all miscarriages. It is helpful in specific situations, particularly in women with early pregnancy bleeding and previous miscarriages. Some miscarriages may occur due to causes that this medicine cannot correct.

Fact Box

Chemical Class

Gluco/mineralocorticoids, progestogin derivative

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Natural Progesterone

References

  1. Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 706-707.
  2. Progesterone [Prescribing Information]. North Chicago, IL: AbbVie Inc.; 2024. [Accessed 22 Jan. 2026] (online) Available from:
  3. Progesterone [Summary of Product Characteristics]. Dublin, Ireland: Besins Healthcare Ireland Limited; 2024. [Accessed 22 Jan. 2016] (online) Available from:
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User feedback

Once A Day
78%
Twice A Day
19%
Thrice A Day
3%
Others
50%
Female infertility
33%
Hormone replacement therapy
17%
Excellent
44%
Poor
33%
Average
22%
No Side Effect
50%
Headache
50%
With or without food
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Emcure Pharmaceuticals Ltd
Address: 255/2, Hinjawadi, Pune - 411057, India / Godown A, Gat No. 408 and 410, Vill: Urse, Tal: Maval, Pune-410 506, Maharashtra, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver EMPRogest 8% Vaginal gel. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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