Zotelet 25mg Tablet

Zotepine (25mg)

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Zotelet 25mg Tablet is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania.

Written By Dr. Mayank, Pharm.D,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 22 Oct 2025 | 04:28 PM (IST)

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Zotepine (25mg)

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General Information

Contains

Zotepine (25mg)

Marketer

Ikon Remedies Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Zotelet 25mg Tablet may be taken with or without food, preferably at the same time, each day. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.

However, discontinue this medicine immediately if you experience neuroleptic malignant syndrome, characterized by fever, muscle rigidity, and altered consciousness or seizures. While taking this medicine your doctor may advise for regular monitoring of liver function.

Some common side effects of this medicine include headache, dryness in the mouth, anxiety, insomnia (difficulty sleeping), and agitation. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it is better to rise slowly if you have been sitting or lying down. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may increase your weight but, modifying your lifestyle by having a healthy diet and exercising regularly can reduce this side effect.

You should be cautious while using this medicine as it may increase the risk of developing diabetes, so it is better to monitor glucose regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

Uses of Zotelet Tablet

Benefits of Zotelet Tablet

Mania
Mania means extremely excited or elevated mood. Zotelet 25mg Tablet helps calm the mood and relax the nerves. This stabilises the mood and prevents the symptoms of mania from recurring again. Taking Zotelet 25mg Tablet will ensure that you have a better social life and are able to do daily activities more comfortably.

Schizophrenia
Schizophrenia is a mental disorder in which a person’s thinking ability, feelings and behavior become abnormal. Zotelet 25mg Tablet helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts, behavior and enhances the quality of life.

Side effects of Zotelet Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zotelet

Headache
Dryness in mouth
Sleepiness
Anxiety
Weight gain
Insomnia (difficulty in sleeping)
Agitation
Sweating
Blurred vision
Depression
Constipation
Increased heart rate

How to use Zotelet Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zotelet 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Zotelet Tablet works

Zotelet 25mg Tablet is an atypical antipsychotic. It works by modulating the action of certain chemical messengers in the brain that affect thoughts.

All substitutes for Zotelet 25mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Zotipax 25mg Tablet

by Intas Pharmaceuticals Ltd

₹4.23/tablet

14% cheaper

Quick tips

Take it at the same time every day to help you remember to take it.
You may be monitored with ECG, electrolytes, and liver function tests before you start treatment with this medicine and while increasing the dose.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Use caution while driving or doing anything that requires concentration as Zotelet 25mg Tablet can cause dizziness and sleepiness.
It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking Zotelet 25mg Tablet without talking to your doctor first as it may cause a worsening of symptoms.

Safety advice

Alcohol

UNSAFE

Zotelet 25mg Tablet may cause excessive drowsiness with alcohol.

Pregnancy

SAFE IF PRESCRIBED

Zotelet 25mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Zotelet 25mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Zotelet 25mg Tablet may cause side effects which could affect your ability to drive.
Zotelet 25mg Tablet may cause sedation and/or impair mental alertness and this may affect your ability to drive.

Kidney

CAUTION

Zotelet 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Zotelet 25mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Zotelet 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Zotelet 25mg Tablet may be needed. Please consult your doctor.

Interaction with drugs

Taking Zotelet with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Zotepine.

Severe

Amiodarone (Oral Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Severe

Hydroxyzine (Oral Route)

Do not consume Hydroxyzine with Zotepine.

Severe

Amiodarone (Injection Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Severe

Artemether (Injection Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Fact Box

Chemical Class

Dibenzothiepine Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Atypical Antipsychotics

References

Stahl SM, editor. Zotepine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 763-67.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ikon Remedies Pvt Ltd
Address: Near Axis Bank, Amrawati Road, Wadi,Nagpur-440 023 (Maharashtra) India / 9, 17th Floor, Lodha Supremus, Opp. MTNL, VLR, Saki Vihar Road, Powai, Mumbai - 72 Regd. off: Wadi - 440 023

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Zotelet 25mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Zotelet Tablet

Benefits of Zotelet Tablet

Side effects of Zotelet Tablet

How to use Zotelet Tablet

How Zotelet Tablet works

All substitutes for Zotelet 25mg Tablet

Zotipax 25mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Domperidone (Oral Route)

Amiodarone (Oral Route)

Hydroxyzine (Oral Route)

Amiodarone (Injection Route)

Artemether (Injection Route)

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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