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Zendryl Syrup

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 02 Mar 2026 | 12:39 PM (IST)
Zendryl Syrup is an antihistaminic medicine. It is used to treat symptoms of nasal allergy such as sneezing, runny nose, itching, and watery eyes. It may also be used to treat insomnia and motion sickness.
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General Information

The content is shown in English
Zendryl Syrup image
Zendryl Syrup image

Product introduction

Zendryl Syrup is best taken before a meal or at bedtime. Take it exactly as prescribed by your doctor. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Take it for as long as it is prescribed for you. In case, you have missed any doses, take the next dose as soon as you remember it. However, you should never take a double dose.

Dizziness and drowsiness are the most common side effect of this medicine. Avoid driving or attention-seeking activities while on treatment with this medicine. In some cases, it may cause also dryness of mouth. To prevent dry mouth, drink more water and maintain good oral hygiene.

Before taking this medicine, let your doctor know if you have glaucoma or have any gastro-related issues or have asthma. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.

Uses of Zendryl Syrup

Benefits of Zendryl Syrup

Treatment of Nasal allergy symptoms
Allergic reactions often involve the release of histamine, a chemical that leads to itching, redness, and inflammation on the skin. When applied, Zendryl Syrup blocks histamine receptors on the skin cells. By reducing histamine's effects, the medicine helps alleviate the uncomfortable symptoms associated with allergic skin conditions, providing relief from itching and reducing inflammation.

Side effects of Zendryl Syrup

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zendryl
  • Dizziness
  • Sedation
  • Drowsiness
  • Dryness in mouth
  • Difficulty in paying attention
  • Fatigue
  • Headache
  • Unsteadiness
  • Impaired coordination
  • Epigastric pain
  • Increased bronchial secretions
  • Dry mucous membrane
  • Constipation
  • Euphoria (feeling of intense excitement and happiness)
  • Abnormality of voluntary movements
  • Discomfort when urinating
  • Hypotension (low blood pressure)
  • Double vision
  • Diaphoresis
  • Erectile dysfunction
  • Early menstrual periods
  • Decreased appetite
  • Allergic sensitization
  • Photosensitivity

How to use Zendryl Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Zendryl Syrup may be taken with or without food.

How Zendryl Syrup works

Zendryl Syrup is an antihistaminic medication. It blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions.

Quick tips

  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Zendryl Syrup, as it may cause excessive sleepiness or drowsiness.
  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Zendryl Syrup, as it may cause excessive sleepiness or drowsiness.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Zendryl Syrup may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Zendryl Syrup is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

CAUTION
Zendryl Syrup should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Larger doses or prolonged use of Zendryl Syrup may cause sleepiness and other effects in the baby
Driving

Driving

UNSAFE
Zendryl Syrup may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Zendryl Syrup in patients with kidney disease. Please consult your doctor.
However, talk to your doctor if you have any underlying kidney disease.
Liver

Liver

CAUTION
Zendryl Syrup should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Zendryl with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Tramadol (Injection Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.
Moderate

Trihexyphenidyl (Injection Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Clozapine (Oral Route)

Watch out for symptoms such as dry mouth, increased heart rate, urination difficulties, constipation, loss of appetite or nausea and consult your doctor if you experience them.
Moderate

Trihexyphenidyl (Oral Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Tramadol (Oral Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.

Fact Box

Chemical Class

Diphenylmethanes

Habit Forming

No

Therapeutic Class

RESPIRATORY

Action Class

First-Generation H1 Antihistamines

References

  1. McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1086.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 414-46.
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
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User feedback

Insomnia
33%
Others
33%
Motion sickness
33%
Excellent
100%
No Side Effect
100%
With food
100%
Average
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Vendor Details

Country of origin: India
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