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Vortuxi Solution for Infusion

Rituximab (500mg)

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Vortuxi Solution for Infusion is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 29 Apr 2026 | 01:02 PM (IST)

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50 ml Solution for Infusion

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General Information

Contains

Rituximab (500mg)

Marketer

Zydus Cadila

Storage

Store below 30°C

The content is shown in English

Product introduction

Vortuxi Solution for Infusion is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.

Before taking it, tell your doctor if you have heart disease, liver, or planning surgery or vaccination or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Vortuxi Solution for Infusion

Rheumatoid arthritis
Blood cancer (Chronic lymphocytic leukemia)
Non-Hodgkin lymphoma (NHL)
Granulomatosis with polyangiitis
Microscopic polyangiitis

Benefits of Vortuxi Solution for Infusion

Granulomatosis with polyangiitis
Granulomatosis with polyangiitis is a condition that causes inflammation of the blood vessels of the ears, nose, throat, lungs, and kidneys. In this condition, the blood flow to these areas may be reduced and it can lead to their damage. Vortuxi Solution for Infusion helps reduce inflammation, pain and swelling and prevents further damage. This improves your quality of life.

Microscopic polyangiitis
Microscopic polyangiitis is an autoimmune disease which occurs in the small blood vessels and may be caused due to problems with the immune system. Vortuxi Solution for Infusion reduces immune response and improves inflammation. This helps to heal this condition and improves your discomfort.

Side effects of Vortuxi Solution for Infusion

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Vortuxi

Headache
Weakness
Infection
Chills
Decreased white blood cell count (neutrophils)
Fever
Infusion site reaction
Lymphopenia
Abdominal pain
Back pain

How to use Vortuxi Solution for Infusion

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

How Vortuxi Solution for Infusion works

Vortuxi Solution for Infusion is a monoclonal antibody. It works by targeting the unwanted activity of immune cells (B cells) in rheumatoid arthritis and certain types of cancers.

All substitutes for Vortuxi Solution for Infusion

For information purposes only. Consult a doctor before taking any medicine.

Ikgdar 500mg Injection

by Cipla Ltd

₹35667.19/solution for infusion

6% costlier

Quick tips

It is given as a drip (intravenous infusion) by your doctor or nurse.
You may be given some painkillers, antihistamine and possibly steroids before the drip to help prevent infusion reaction.
Your doctor may get blood tests done to check for hepatitis B before treatment and to monitor your blood cells during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Inform your doctor if you have any heart rhythm problems, if you are having surgery or if you plan to get any vaccinations.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Vortuxi Solution for Infusion. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Vortuxi Solution for Infusion is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Vortuxi Solution for Infusion should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Vortuxi Solution for Infusion alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Vortuxi Solution for Infusion should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Vortuxi Solution for Infusion should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Vortuxi Solution for Infusion is not recommended in patients with the active liver disease or those who had viral hepatitis as it can reactivate the infection.

Interaction with drugs

Taking Vortuxi with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Rituximab with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If Rituximab is essential, ensure a gap of at least 12 months after discontinuing Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). Please consult your doctor.

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Rituximab with Cholera Vaccine (Inactivated). If Rituximab is essential, ensure a gap of at least 12 months after discontinuing Cholera Vaccine (Inactivated). Please consult your doctor.

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Rituximab with Purified Vi Polysaccharide Typhoid Vaccine. If Rituximab is essential, ensure a gap of at least 12 months after discontinuing Purified Vi Polysaccharide Typhoid Vaccine. Please consult your doctor.

Moderate

Clozapine (Oral Route)

Your doctor may monitor your blood cell count and adjust the doses as per the observations.

Moderate

Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant (Injection Route)

Please consult with your doctor regarding minimum time interval required between Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant and Rituximab.

Frequently asked questions

What is Vortuxi Solution for Infusion used for?

Vortuxi Solution for Infusion is used to treat several immune-related diseases and cancers, including non-Hodgkin lymphoma, chronic lymphocytic leukemia (CLL), granulomatosis with polyangiitis, and microscopic polyangiitis. In rare cases, your doctor may also prescribe this medicine to treat pemphigus vulgaris and moderate to severe rheumatoid arthritis when other treatments have not worked.

Why do doctors give Vortuxi Solution for Infusion for both cancer and autoimmune diseases?

Vortuxi Solution for Infusion helps control overactive immune cells, which play a role in certain cancers and inflammatory diseases. This makes it useful across multiple conditions that involve harmful immune activity.

Who should not receive Vortuxi Solution for Infusion?

Vortuxi Solution for Infusion should not be given to anyone who has had a severe, life-threatening allergic reaction to rituximab or its ingredients in the past. If you have had a serious infusion reaction before, your doctor will consider alternatives.

What are the serious side effects of Vortuxi Solution for Infusion?

Serious side effects of Vortuxi Solution for Infusion include severe infusion reactions, severe skin reactions, heart-related problems, and life-threatening infections. Your doctor and care team will monitor you closely during and after infusions to catch these early.

Can Vortuxi Solution for Infusion cause dangerous infusion reactions?

Yes. Some people may have serious or life-threatening reactions during, or within 24 hours of receiving Vortuxi Solution for Infusion, including breathing difficulty, swelling, dizziness, or sudden drops in blood pressure. This is why the first dose is given slowly and under close supervision.

Does Vortuxi Solution for Infusion increase my risk of infections?

Vortuxi Solution for Infusion can weaken your immune defenses and increase the chance of infections, including serious viral, bacterial, or fungal infections. Rare but severe infections such as progressive multifocal leukoencephalopathy (PML), a brain infection, have been reported. Call your doctor if you develop fever, confusion, weakness, or new neurological symptoms.

Can Vortuxi Solution for Infusion reactivate old infections like hepatitis B?

Yes. Vortuxi Solution for Infusion can reactivate the hepatitis B virus in people who previously had the infection. This can be life-threatening. Doctors routinely test for hepatitis B before beginning therapy, and may do regular blood checks during treatment.

Does Vortuxi Solution for Infusion affect the heart?

Some people experience irregular heartbeat, chest pain, or low blood pressure during Vortuxi Solution for Infusion infusion. Those with heart problems may need extra monitoring. Report any chest discomfort or unusual heartbeat immediately.

Are there people who need extra caution before getting Vortuxi Solution for Infusion?

Yes. Before starting Vortuxi Solution for Infusion, let your doctor know if you have heart disease, lung problems, a current infection, a history of hepatitis B, low immune function, or recent or planned vaccines. These conditions may require additional testing or treatment adjustments.

Can Vortuxi Solution for Infusion cause long-term immune changes?

As Vortuxi Solution for Infusion lowers certain immune cells for months, some people may have delayed infections or may respond less effectively to vaccines. Doctors often monitor blood tests during and after treatment to ensure immune recovery.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Anti-CD20 Monoclonal Antibodies

Related lab tests

Complete Blood Count

Peripheral Smear Examination

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1745-48.
Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 978.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1225-27.
Rituximab. Garden City, Hertfordshire: Roche Products Limited; 1998 [revised 18 Dec. 2018]. [Accessed 25 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Rituximab. [Updated 2020 Jan 20]. [Accessed 18 Feb. 2020] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zydus Cadila
Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Vortuxi Solution for Infusion. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Vortuxi Solution for Infusion

Payment

Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Vortuxi Solution for Infusion

Benefits of Vortuxi Solution for Infusion

Side effects of Vortuxi Solution for Infusion

How to use Vortuxi Solution for Infusion

How Vortuxi Solution for Infusion works

All substitutes for Vortuxi Solution for Infusion

Ikgdar 500mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Cholera Vaccine (Inactivated) (Oral Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Clozapine (Oral Route)

Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant (Injection Route)

Frequently asked questions

What is Vortuxi Solution for Infusion used for?

Why do doctors give Vortuxi Solution for Infusion for both cancer and autoimmune diseases?

Who should not receive Vortuxi Solution for Infusion?

What are the serious side effects of Vortuxi Solution for Infusion?

Can Vortuxi Solution for Infusion cause dangerous infusion reactions?

Does Vortuxi Solution for Infusion increase my risk of infections?

Can Vortuxi Solution for Infusion reactivate old infections like hepatitis B?

Does Vortuxi Solution for Infusion affect the heart?

Are there people who need extra caution before getting Vortuxi Solution for Infusion?

Can Vortuxi Solution for Infusion cause long-term immune changes?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

User feedback

What are you using Vortuxi Solution for Infusion for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests