Volibris Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Volibris Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It can even help improve your quality of life, exercise ability, and delay disease progression.

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₹2091 MRP ₹2315.1810% off

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Ambrican 5 Tablet

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Volibris Tablet

strip of 10 tablets

₹2091

~~₹2315.18~~

Same composition

Ambrican 5 Tablet

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Ambrisentan (5mg)

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General Information

Contains

Ambrisentan (5mg)

Marketer

Glaxo SmithKline Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Volibris Tablet may be taken with or without food. Take it in the dose and duration advised by your doctor. In case you missed a dose, take another one as soon as you remember it. Take it for as long as it is prescribed and do not stop taking the medicine on your own.

The most common side effects of this medicine are peripheral edema, nasal congestion, sinusitis, and flushing. Let your doctor know if any of these side effects bother you or persist for a longer duration. Dizziness may also occur in some people, so do not drive or do anything that requires mental focus if you experience such a symptom.

Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. It should be used with caution in patients with liver or kidney disease. Attend regular follow-ups as advised by the doctor.

Uses of Volibris Tablet

Treatment of Pulmonary arterial hypertension (PAH)

Benefits of Volibris Tablet

Treatment of Pulmonary arterial hypertension (PAH)
Pulmonary arterial hypertension (PAH) is a condition in which the blood pressure in the arteries of the lungs becomes abnormally high, causing the heart to work harder and leading to symptoms such as breathlessness, fatigue, and chest pain. Volibris Tablet is used to treat PAH by helping relax and widen the blood vessels in the lungs. This improves blood flow, lowers lung pressure, and makes it easier to perform daily activities with reduced symptoms, ultimately enhancing exercise capacity and quality of life.

Side effects of Volibris Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Volibris

Peripheral edema
Nasal congestion (stuffy nose)
Sinus inflammation
Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Volibris Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Volibris Tablet may be taken with or without food.

How Volibris Tablet works

Volibris Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Volibris Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

All substitutes for Volibris Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Volibris Tablet helps improve your quality of life, exercise ability, and delay disease progression.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Volibris Tablet affects you.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Volibris Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Volibris Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Volibris Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Volibris Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Volibris Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Volibris Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Limited information is available on use of Volibris Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

CAUTION

Volibris Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Volibris with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Rifampicin (Oral Route)

Your doctor may monitor your treatment. Rifampicin may raise blood levels of Ambrisentan.

Moderate

Rifampicin (Injection Route)

Your doctor may monitor your treatment. Rifampicin may raise blood levels of Ambrisentan.

Moderate

Ciclosporin (Oral Route)

Watch out for symptoms such as constipation, flushing or swelling under the skin and consult your doctor if you experience them. Ciclosporin may raise blood levels of Ambrisentan.

Moderate

Ciclosporin (Injection Route)

Watch out for symptoms such as constipation, flushing or swelling under the skin and consult your doctor if you experience them. Ciclosporin may raise blood levels of Ambrisentan.

Mild

Conjugated Estrogens (Vaginal Route)

Talk to your doctor if you notice any unusual symptoms. Ambrisentan may raise blood levels of Conjugated Estrogens.

Frequently asked questions

Can Volibris Tablet cause liver problems?

Yes, Volibris Tablet commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.

How should Volibris Tablet be taken?

Usually, the doctors advise to take one dose of Volibris Tablet. You can take it with or without food but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.

Can I stop taking Volibris Tablet on my own?

No, you should not stop taking Volibris Tablet without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.

What is the most important thing that I should know about Volibris Tablet?

Volibris Tablet may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Volibris Tablet. Additionally, during treatment with Volibris Tablet you should use two reliable methods of contraception to ensure that you do not get pregnant.

What are the serious side effects of Volibris Tablet?

The serious side effects of Volibris Tablet are swelling all over the body (fluid retention), decreased sperm count and low red blood cell count (anemia). Tell your doctor if you have any unusual weight gain, tiredness, or trouble breathing.

Why have I been prescribed Volibris Tablet?

Volibris Tablet is used to treat pulmonary hypertension in adults. Pulmonary hypertension is a condition wherein there is increased blood pressure in the pulmonary arteries (blood vessels that carry blood from heart to lungs). Volibris Tablet lowers the blood pressure by relaxing the pulmonary arteries, making it easier for the heart to pump blood through them.

What are the symptoms of overdose of Volibris Tablet?

Taking more than the recommended dose of Volibris Tablet may cause headache, flushing, dizziness, or nausea. It may cause low blood pressure which may further lead to lightheadedness. Contact your doctor immediately or seek emergency medical services in a nearby hospital if you take more than the recommended doses of this medicine.

Fact Box

Chemical Class

Diphenylmethanes

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin Receptor Antagonists (ERAs)

References

Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 39-50.
Ambrisentan [EMC SmPC]. London, UK: GlaxoSmithKline UK; 2025. [Accessed 06 Nov. 2025] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
Ambrisentan [Patient Information Leaflet]. Cape Town, South Africa: Cipla Medpro (Pty) Ltd.; 2022. [Accessed 06 Nov, 2025] (online) Available from:
Letairis (Ambrisentan) [Product Information]. [Accessed 09 Jun, 2023] (online) Available from:

User feedback

Patients taking Volibris Tablet

Once A Day

92%

Twice A Day

What are you using Volibris Tablet for?

Pulmonary arterial hypertension (PAH)

100%

How much was the improvement?

Poor

67%

Average

33%

What were the side-effects while using Volibris Tablet?

No Side Effect

100%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030

Vendor Details

Country of origin: Canada

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Volibris Tablet

Save more with additional offers

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Volibris Tablet

Benefits of Volibris Tablet

Side effects of Volibris Tablet

How to use Volibris Tablet

How Volibris Tablet works

All substitutes for Volibris Tablet

ENDobloc 5 Tablet

Ambrican 5 Tablet

Pulmonext 5 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Rifampicin (Oral Route)

Rifampicin (Injection Route)

Ciclosporin (Oral Route)

Ciclosporin (Injection Route)

Conjugated Estrogens (Vaginal Route)

Frequently asked questions

Can Volibris Tablet cause liver problems?

How should Volibris Tablet be taken?

Can I stop taking Volibris Tablet on my own?

What is the most important thing that I should know about Volibris Tablet?

What are the serious side effects of Volibris Tablet?

Why have I been prescribed Volibris Tablet?

What are the symptoms of overdose of Volibris Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Volibris Tablet

What are you using Volibris Tablet for?

How much was the improvement?

What were the side-effects while using Volibris Tablet?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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