Author Details
Written By
Reviewed By
MD Pharmacology, MBBS
Last updated
05 Dec 2022 | 11:47 PM (IST)

We provide you with authentic, trustworthy and revelant information

Want to know more

Have issue with the content?

Report Problem

Endobloc 5 Tablet

Prescription Required
Manufacturer/ Marketer
Store below 30°C

Product introduction

Endobloc 5 Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Endobloc 5 Tablet may be taken with or without food but, it is better to take it in a dose and duration as advised by the doctor. In case, you have missed any dose than it is better to take another one as soon as you remember it.

Dizziness may occur as its side effect, so do not drive or do anything that requires mental focus. You may also have other side effects like, headache, palpitations, breathlessness, runny nose, feeling sick, diarrhea or fatigue. Let your doctor know if any of these side effects bothers you or persists for a longer duration.

Benefits of Endobloc Tablet

In Pulmonary arterial hypertension (PAH)

Pulmonary arterial hypertension can cause shortness of breath, tiredness, dizziness, chest pain and swelling in your ankles and legs. It is caused by thickening of walls of the arteries that supply your lungs making it hard for blood to get through. Endobloc 5 Tablet relaxes the blood vessels and can help lower the blood pressure in the arteries of your lungs. You will be able to carry out your daily activities more easily and feel less tired or dizzy.

Side effects of Endobloc Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Endobloc

  • Sinus inflammation
  • Nasal congestion (stuffy nose)
  • Peripheral edema
  • Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Endobloc Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Endobloc 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Endobloc Tablet works

Endobloc 5 Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Endobloc 5 Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

Safety advice

It is not known whether it is safe to consume alcohol with Endobloc 5 Tablet. Please consult your doctor.
Endobloc 5 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
Information regarding the use of Endobloc 5 Tablet during breastfeeding is not available. Please consult your doctor.
Endobloc 5 Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Endobloc 5 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Endobloc 5 Tablet may be needed. Please consult your doctor.
Limited information is available on use of Endobloc 5 Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
Endobloc 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Endobloc 5 Tablet may be needed. Please consult your doctor.

What if you forget to take Endobloc Tablet?

If you miss a dose of Endobloc 5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Endobloc 5 Tablet
Zambri 5mg Tablet
Zydus Cadila
21% cheaper
Ibitan 5mg Tablet
Indiabulls pharmaceutical ltd
21% cheaper
Pulmonext 5 Tablet
MSN Laboratories
13% cheaper
18% costlier
Volibris Tablet
Glaxo SmithKline Pharmaceuticals Ltd
35% costlier

Quick tips

  • Your doctor has prescribed Endobloc 5 Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Endobloc 5 Tablet affects you.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Endobloc 5 Tablet as it is toxic to an unborn baby.
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.

Fact Box

Chemical Class
Diphenylmethanes Derivative
Habit Forming
Therapeutic Class
Action Class
Endothelin receptor blocker

Interaction with drugs

Taking Endobloc with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Imudrops, Neoral, Aurosporine
Brand(s): Altrom, Cenorol, Cgtrom
Brand(s): Cofarin, Sofarin, Warf
Brand(s): Dindevan

Patient concerns

Hi my mother is prescibed : endobloc5 ta let So i want to ask is Volibris 5 mg tablet will suit her ? As she is suffering from low blood pressure and plumonary arterial problem
Dr. Vitrag Shah
Endobloc & volibris both have similar content, check it out. Amrisentan 5mg.
Having high Pulmonary Atrial Hypertension
Dr. Nabajit Talukdar
What medicines r u on

User feedback


Q. Can Endobloc 5 Tablet cause liver problems?

Yes, Endobloc 5 Tablet commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.

Q. How should Endobloc 5 Tablet be taken?

Usually, the doctors advise to take one dose of Endobloc 5 Tablet. You can take it with or without food at any time of the day but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.

Q. Can I stop taking Endobloc 5 Tablet on my own?

No, you should not stop taking Endobloc 5 Tablet without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.

Q. What is the most important thing that I should know about Endobloc 5 Tablet?

Endobloc 5 Tablet may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Endobloc 5 Tablet. Additionally, during treatment with Endobloc 5 Tablet you should use two reliable methods of contraception to ensure that you do not get pregnant.

Q. What are the serious side effects of Endobloc 5 Tablet?

The serious side effects of Endobloc 5 Tablet are swelling all over the body (fluid retention), decreased sperm count and low red blood cell count (anemia). Tell your doctor if you have any unusual weight gain, tiredness, or trouble breathing.

Q. Why have I been prescribed Endobloc 5 Tablet?

Endobloc 5 Tablet is used to treat pulmonary hypertension in adults. Pulmonary hypertension is a condition wherein there is increased blood pressure in the pulmonary arteries (blood vessels that carry blood from heart to lungs). Endobloc 5 Tablet lowers the blood pressure by relaxing the pulmonary arteries, making it easier for the heart to pump blood through them.

Q. What are the symptoms of overdose of Endobloc 5 Tablet?

Taking more than the recommended dose of Endobloc 5 Tablet may cause headache, flushing, dizziness, or nausea. It may cause low blood pressure which may further lead to lightheadedness. Contact your doctor immediately or seek emergency medical services in a nearby hospital if you take more than the recommended doses of this medicine.

Want to share the information?


Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 39-50.
  3. Name of medicine. Citywest Business Campus Dublin: GlaxoSmithKline (Ireland) Limited; 2008 [revised 31 Oct. 2018]. [Accessed 01 Apr. 2019] (online) Available from:External Link
  4. Ambrisentan. Uxbridge, Middlesex: GlaxoSmithKline UK; 2008 [revised 31 Oct. 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Country of origin: India
Expires on or after: July, 2024

A licensed vendor partner from your nearest location will deliver Endobloc 5 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
1463.441829.3Get 20% OFF
1335.38+ free shipping and 5% Extra cashback with
Care plan members get extra discounts, free shipping, free health screening, premium doctor consultation and more.
Inclusive of all taxes
This offer price is valid on orders above ₹1799. Apply coupon FLAT20 on the cart. Max. coupon discount is ₹600. T&C apply.
10 tablets in 1 strip
Add to cart
Cash on delivery available
Earliest delivery by 5pm, Tomorrow
Delivering to:
110020, New Delhi

Additional offers

Paytm Wallet: Pay with Paytm wallet on Tata 1mg for ₹599 or more and get 3000 cashback points. Offer ends 31st December 2022.
Show more show_more


Orders Delivered
Get the link to download App

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited


Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant


Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

LegitScript approved
India's only LegitScript and ISO/ IEC 27001 certified online healthcare platform

Know more about Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.