Information about Ambrisentan

Ambrisentan Uses

Ambrisentan is used in the treatment of pulmonary arterial hypertension (PAH).

How Ambrisentan works

Ambrisentan is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Ambrisentan helps relax these blood vessels and increases the supply of blood to the lungs.

Common side effects of Ambrisentan

Sinus inflammation, Nasal congestion (stuffy nose), Peripheral edema, Flushing (sense of warmth in the face, ears, neck and trunk)
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Written By
MMST, MBBS
Reviewed By
MD (Pharmacology), MBBS
Last updated
13 Jun 2022 | 07:20 PM (UTC)

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Available Medicine for Ambrisentan

EndoblocCipla Ltd
1829 to ₹29922 variant(s)
PulmonextMSN Laboratories
1592 to ₹25802 variant(s)
AmbricanLupin Ltd
21661 variant(s)
VolibrisGlaxo SmithKline Pharmaceuticals Ltd
24691 variant(s)
IbitanIndiabulls pharmaceutical ltd
14501 variant(s)
ZambriZydus Cadila
1450 to ₹23502 variant(s)

Expert advice for Ambrisentan

  • Your doctor has prescribed Ambrisentan to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Ambrisentan affects you.
  • Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Ambrisentan as it is toxic to an unborn baby.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.

Frequently asked questions for Ambrisentan

Ambrisentan

Q. Can Ambrisentan cause liver problems?

Yes, Ambrisentan commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.

Q. How should Ambrisentan be taken?

Usually, the doctors advise to take one dose of Ambrisentan. You can take it with or without food at any time of the day but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.

Q. Can I stop taking Ambrisentan on my own?

No, you should not stop taking Ambrisentan without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.

Q. What is the most important thing that I should know about Ambrisentan?

Ambrisentan may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Ambrisentan. Additionally, during treatment with Ambrisentan you should use two reliable methods of contraception to ensure that you do not get pregnant.

Q. What are the serious side effects of Ambrisentan?

The serious side effects of Ambrisentan are swelling all over the body (fluid retention), decreased sperm count and low red blood cell count (anemia). Tell your doctor if you have any unusual weight gain, tiredness, or trouble breathing.

Q. Why have I been prescribed Ambrisentan?

Ambrisentan is used to treat pulmonary hypertension in adults. Pulmonary hypertension is a condition wherein there is increased blood pressure in the pulmonary arteries (blood vessels that carry blood from heart to lungs). Ambrisentan lowers the blood pressure by relaxing the pulmonary arteries, making it easier for the heart to pump blood through them.

Q. What are the symptoms of overdose of Ambrisentan?

Taking more than the recommended dose of Ambrisentan may cause headache, flushing, dizziness, or nausea. It may cause low blood pressure which may further lead to lightheadedness. Contact your doctor immediately or seek emergency medical services in a nearby hospital if you take more than the recommended doses of this medicine.

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