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Ambrisentan is used for the treatment of pulmonary arterial hypertension, a condition in which blood pressure rises due to narrowing of the arteries supplying blood from the heart to the lungs.

How it works

Ambrisentan belongs to a class of drugs called as endothelin receptor antagonists. It acts by inhibiting endothelin that causes narrowing of blood vessels and thus reduces the blood pressure by widening the arteries.

Common side effects

Nausea, Palpitations, Peripheral edema, Liver transaminases increased, Abdominal pain, Anemia, Constipation, Dizziness, Shortness of breath, Flushing, Nasal congestion, Nasopharyngitis, Sinus inflammation, Vomiting


Expert advice

  • Inform your doctor before taking the medicine if you have liver problems, peripheral edema (swelling in the hands and legs due to fluid retention), anemia (low hemoglobin or red blood cells in the blood), pulmonary veno-occlusive disease (blockage of the veins in the lungs), intolerance to some sugars, or soya allergy.
  • Do not drive or operate heavy machinery after taking this medicine as the drug or your condition may cause dizziness and tiredness.
  • Inform your doctor if you are taking other medicines such as cyclosporine A, rifampicin or other medicines such as epoprostenol, sildenafil etc.
  • Ambrisentan is not recommended for children under 18 years of age.
  • Inform your doctor if you intend to father a child, as ambrisentan may lower your sperm count.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)