Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Interaction with drugs
Patient concerns
FAQs

Author Details

Written By

Dr. Subita Alagh

BDS

Reviewed By

Dr. Lalit Kanodia

MBA, MD Pharmacology

Last updated

21 Sep 2025 | 05:36 PM (IST)

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Venlayork 37.5 Tablet PR

Prescription Required

Marketer

Mediverge Healthcare Pvt Ltd

SALT COMPOSITION

Venlafaxine (37.5mg)

Storage

Store below 25°C

View available alternative with same salt composition

Click here to view all substitutes

Product introduction

Venlayork 37.5 Tablet PR is a medicine used to treat major depressive disorder and anxiety disorders. It helps improve mood, reduce nervousness, and improve overall well-being by restoring the balance of certain brain chemicals that affect mood and emotions.

Venlayork 37.5 Tablet PR should be taken with food. Take this medicine at the same time each day to maintain a stable level in your blood. If you miss a dose, take it as soon as you remember. Do not skip doses, and complete the full course of treatment even if you feel better. Do not stop taking this medication abruptly, as it may worsen your symptoms.

Some common side effects of this medicine include nausea, insomnia (difficulty sleeping), constipation, increased sweating, and sexual dysfunction. However, these side effects are temporary and typically resolve on their own over time. Consult your doctor if these do not subside or bother you.

Venlayork 37.5 Tablet PR may cause dizziness and drowsiness, so avoid driving or engaging in activities that require mental focus until you understand how this medicine affects you. Before taking Venlayork 37.5 Tablet PR, inform your doctor if you have any kidney, heart, or liver conditions or a history of seizures (epilepsy or fits). Additionally, notify your doctor if you experience any unusual mood or behavioral changes, worsening depression, or suicidal thoughts. Pregnant and breastfeeding women should consult before taking this medicine, as it may cause harmful effects on the developing baby.

Uses of Venlayork Tablet PR

Benefits of Venlayork Tablet PR

In Depression

Venlayork 37.5 Tablet PR is used to treat depression by improving mood-regulating chemicals in the brain. It helps restore emotional balance, reducing feelings of sadness, hopelessness, and fatigue. Improving energy levels and motivation helps to regain interest in daily activities and improves overall well-being.

In Anxiety disorder

Venlayork 37.5 Tablet PR helps manage anxiety disorders by balancing neurotransmitters in the brain, particularly serotonin and norepinephrine. It reduces excessive worry, restlessness, and nervousness, helping individuals feel calmer and more in control.

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Side effects of Venlayork Tablet PR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Venlayork

Nausea
Constipation
Increased sweating
Sexual dysfunction
Dizziness
Decreased appetite
Erectile dysfunction

How to use Venlayork Tablet PR

Use it as advised by your doctor or check the label for directions before use. Venlayork 37.5 Tablet PR is to be taken with food.

How Venlayork Tablet PR works

Venlayork 37.5 Tablet PR works by increasing the levels of chemical messengers (serotonin and noradrenaline). These are natural substances in the brain that help maintain mental balance and manage depression and anxiety.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Venlayork 37.5 Tablet PR.

Pregnancy

CONSULT YOUR DOCTOR

Venlayork 37.5 Tablet PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Venlayork 37.5 Tablet PR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Babies should be monitored for excessive sleepiness and adequate weight gain.

Driving

UNSAFE

Venlayork 37.5 Tablet PR may cause side effects which could affect your ability to drive.
Venlayork 37.5 Tablet PR may cause dizziness, confusion, and eyesight changes such as blurred vision, which may affect your ability to drive.

Kidney

CAUTION

Venlayork 37.5 Tablet PR should be used with caution in patients with kidney disease. Dose adjustment of Venlayork 37.5 Tablet PR may be needed. Please consult your doctor.

Liver

CAUTION

Venlayork 37.5 Tablet PR should be used with caution in patients with liver disease. Dose adjustment of Venlayork 37.5 Tablet PR may be needed. Please consult your doctor.

What if you forget to take Venlayork Tablet PR?

If you miss a dose of Venlayork 37.5 Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Venlayork 37.5 Tablet PR

₹5.42/Tablet PR

Ventab XL 37.5 Tablet

Intas Pharmaceuticals Ltd

₹6.84/tablet pr

26% costlier

Venjoy XR 37.5 Tablet

Manas Pharma MFG

₹5/tablet pr

8% cheaper

Quick tips

It may take 2 to 4 weeks for Venlayork 37.5 Tablet PR to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Venlayork 37.5 Tablet PR, as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Consult your doctor if you experience sudden mood changes or have suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.

Fact Box

Chemical Class

Anisole Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

Interaction with drugs

Taking Venlayork with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moclobemide (Oral Route) Life-threatening

Do not consume Moclobemide with Venlafaxine. If concurrent use is essential, please consult your doctor. Concomitant use may cause an increase in blood serotonin levels. Patients ... More

Selegiline (Oral Route) Life-threatening

Do not consume Selegiline with Venlafaxine. If Selegiline is essential, ensure a gap of at least 2 weeks after discontinuing Venlafaxine. Please consult your doctor. Concomitant u... More

Domperidone (Oral Route) Life-threatening

Do not consume Venlafaxine with Domperidone. Concomitant use may affect heart rhythm and can be fatal.

Tapentadol (Nasal Route) Life-threatening

Avoid concurrent use unless your doctor considers it safe. Concurrent use may cause fatal rise in blood serotonin levels.

Zolmitriptan (Nasal Route) Life-threatening

If concurrent use is essential, watch out for symptoms of serotonin syndrome such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doct... More

View all drug interactions

Patient concerns

Mental Depression , Anxiety disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.

Mixed anxiety depressive disorder

Dr. Jyoti Kapoor Madan

Psychiatry

What are possible physical symptoms of anxiety disorder and depression.

Dr. Subrata Naskar

Psychiatry

Hi PATIENT me clear that for you. Depression is usually associated with a lot of physical symptoms like increased fatigue, decreased amount of sleep or interrupted sleep, loss of appetite usually cause more than 5% body weight loss, loss of libido. But its effect is mainly psychological whivh causes persist low mood, inability to enjoy pleasurable activities, low self esteem, bleak view of the future, guilty feeling etc. These symptoms have to be present persistently for 2 weeks to be called depression. On the other hand, anxiety has two main components, worry and fear. The common physical complaints are extreme sweating, butterfly like feeling in stomach, fidgetiness, increased frequency of urination. If associated with panic attacks, there is often palpitation, respiratory distress, dryness of throat, a sense of doom. Anxiety disorders are of various types and each have varied specific set of symptoms, but these are usually in common.

SUFFERING FROM ACIDITY, SLEEP DISORDER, NAUSIA, DEPRESSION AND ANXIETY AND ALSO FATTY LIVER

Dr. Saurav Arora

Homeopathy

Dear sir your problem can surely be treated with homeopathy but as your case is a chronic case it requires long case taking, examination and regular follow up, therefore, please visit a homeopath so that he can examine you and guide you accordingly. Till the time you can start taking Ipecac 30, 4 drops in half cup water thrice daily. For Do?s and Don?ts while taking homeopathic medicines visit www.arorasclinic.com/homeopathy

Anxiety disorder from.past 4 years taking paroxitine and clonazepam 12.5 /0.5 mg

Dr. Jyoti Kapoor Madan

Psychiatry

Based in your clinical history, your doctor plans the type of medicine and it's dose and duration. For first episode of anxiety/ depression/ panic, the usual maintenance phase is 6 months of asymptomatic period, after which medicines can be gradually tapered. But treatment may need to continue longer depending on severity and frequency of episodes. To take any decision to change medication or stop them, several factors have to be taken in account for which regular follow up with your psychiatrist is important. For second opinion, seek a proper consultation with another psychiatrist and take along your previous prescriptions.

Severe Major Depression Disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Can Venlayork 37.5 Tablet PR cause sedation?

Yes. Venlayork 37.5 Tablet PR can cause sedation. You should inform your doctor if you are taking any other sleep-inducing medicines before starting Venlayork 37.5 Tablet PR.

Is Venlayork 37.5 Tablet PR a psychotropic drug?

Yes. Venlayork 37.5 Tablet PR is a psychotropic drug. Any medication capable of affecting the mind, emotions, and behaviour are called psychotropic drugs.

Is Venlayork 37.5 Tablet PR a narcotic?

No. Venlayork 37.5 Tablet PR is not a narcotic drug. Narcotics are drugs with sleep-inducing properties, usually derivatives of opium, like heroin and morphine.

Can I take mirtazapine along with Venlayork 37.5 Tablet PR?

No. There can be a serious side effect when mirtazapine is taken with Venlayork 37.5 Tablet PR. It can cause a serious condition called as serotonin syndrome. It is a potentially life-threatening can present as agitation, hallucinations, nausea, vomiting, diarrhoea, tachycardia, labile blood pressure, hyperthermia and coma.

Can I take Venlayork 37.5 Tablet PR with citalopram?

No. Citalopram and Venlayork 37.5 Tablet PR both increase serotonin levels. Avoid or use any alternate drug. It can cause a serious condition called as serotonin syndrome. It is a potentially life-threatening can present as agitation, hallucinations, nausea, vomiting, diarrhoea, tachycardia, labile blood pressure, hyperthermia and coma.

What is the relation between Venlayork 37.5 Tablet PR and p-glycoprotein?

P-glycoprotein is responsible for the expulsion of Venlayork 37.5 Tablet PR from the brain. Some studies have shown that Venlayork 37.5 Tablet PR and its metabolite inhibit the p-glycoprotein.

Can Venlayork 37.5 Tablet PR cause high blood pressure?

Venlayork 37.5 Tablet PR treatment is associated with sustained increases in blood pressure in some people. It is recommended that people who are being treated with Venlayork 37.5 Tablet PR should have regular monitoring of blood pressure. For such people, either dose reduction or discontinuation should be considered.

Can Venlayork 37.5 Tablet PR cause constipation?

Yes. Venlayork 37.5 Tablet PR is known to cause constipation in some patients. Take a fiber-rich diet and drink plenty of water. You may consider taking laxatives as well. Your doctor will suggest ways to prevent or manage it. Please consult your doctor if it does not resolve or gets worse.

Can Venlayork 37.5 Tablet PR cause weight loss?

Yes. Venlayork 37.5 Tablet PR is known to cause weight loss in some patients. In research studies, a dose-dependent weight loss was noted in patients treated with Venlayork 37.5 Tablet PR for several weeks. Please consult your doctor if it bothers you.

Can Venlayork 37.5 Tablet PR cause addiction?

No. Venlayork 37.5 Tablet PR does not have habit-forming potential.

Can I take Venlayork 37.5 Tablet PR tablet instead of a capsule?

You can take a tablet instead of the capsule but only under consultation or prescription of a doctor. You should not change it yourself as the different formulation of a medication may have a different action as drug release would be different in both. This can lead to an inappropriate treatment and may lead to side effects or even failure of treatment.

Can gabapentin be given along with Venlayork 37.5 Tablet PR?

Yes, gabapentin can be given with Venlayork 37.5 Tablet PR, but only with a consultation with a doctor. They both, when given together, cause an increase in drowsiness, sleepiness, and decreased concentration at work. Take it with caution.

Can fibromyalgia be treated with Venlayork 37.5 Tablet PR?

Venlayork 37.5 Tablet PR is not approved for the treatment of fibromyalgia. Some research studies have shown promising results of Venlayork 37.5 Tablet PR in the treatment of fibromyalgia. Consult your doctor before starting this medication.

Can nerve pain be treated with Venlayork 37.5 Tablet PR?

Venlayork 37.5 Tablet PR is not approved for treatment of nerve pain disorders but some researchers have proved its efficacy in nerve pain. It is currently used off-label for nerve pain.

Why does Venlayork 37.5 Tablet PR cause loss of appetite?

Venlayork 37.5 Tablet PR is known to cause changes in the neurotransmitters levels and chemicals in the brain which leads to decrease in appetite and this loss of appetite is dose dependent.

What are good alternatives to Venlayork 37.5 Tablet PR, particularly when a side effect is reduced sex drive?

If you find any side effects like decreased sex drive or impotence, talk to your doctor, and then you can have another drug. Do not stop Venlayork 37.5 Tablet PR by yourself, it can lead to increased adverse effects.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Stahl SM, editor. Venlafaxine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 721-26.
DeBattista C. Antidepressant Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 513.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1466.
Venlafaxine [FDA Label]. Marietta, GA: Urban Pharmaceuticals Inc.; 1993 [revised Jun. 2014]. [Accessed 19 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Venlafaxine. [Updated 2019 Oct 23]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Venlafaxine hydrochloride [Drug Label]. Pfizer; 2021. [Accessed 18 Feb. 2025] (online) Available form:
Venlafaxine Extended-Release [Prescribing Information]. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2017. [Accessed 18 Feb. 2025] (online) Available from: