Tobihale 300mg Respules is an antibiotic used to prevent or treat infections of the lung (e.g., pneumonia). It is particularly effective in managing lung infections in people suffering from a disease known as cystic fibrosis.

Tobihale 300mg Respules is only meant for inhalation using a nebulizer. The solution should not be injected or swallowed. It works by stopping the growth of bacteria. This helps to improve your symptoms and resolve the underlying infection. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.

Common side effets of this medicine include increased may cause cough, pharyngitis, change in taste, or voice change as side effects in some patients. These are temporary and usually resolve with time. Regular rinsing of the mouth with warm saline water and the use of lozenges may help you to overcome the side effects. Consult your doctor if any of the side effects persist or if your condition does not improve.

Your doctor may advise you periodic blood counts and kidney function tests for monitoring. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding before using this medicine.

Uses of Tobihale Respules

Treatment and prevention of Lung infections in patients with cystic fibrosis

Benefits of Tobihale Respules

In Treatment and prevention of Lung infections in patients with cystic fibrosis

People with cystic fibrosis (CF) are at greater risk of getting lung infections because thick, sticky mucus builds up in their lungs, allowing infectious bacteria to grow and multiply. Lung infections are a serious problem for such patients because they can lead to severe or worsening lung disease. Tobihale 300mg Respules helps treat lung infections in such people and also improves lung function. This helps to prevent further complications and prolongs the life of CF patients. Follow your doctor’s instructions carefully to get the most benefit from Tobihale 300mg Respules.

Side effects of Tobihale Respules

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tobihale

Taste change
Voice change
Rash
Coughing up blood
Breathlessness
Sore throat
Cough
Increased sputum production
Lung disorder

How to use Tobihale Respules

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Twist off the top of the respule/transpule and squeeze all the liquid into the nebulizer. It should be used right away after opening.

How Tobihale Respules works

Tobihale 300mg Respules is an antibiotic. It stops bacterial growth in the airways by preventing synthesis of essential proteins required by bacteria to carry out vital functions. This treats infection in the airways.

Safety advice

Alcohol

SAFE

Consuming alcohol with Tobihale 300mg Respules does not cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Tobihale 300mg Respules is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Tobihale 300mg Respules is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

What if you forget to take Tobihale Respules?

If you miss a dose of Tobihale 300mg Respules, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Tobihale 300mg Respules

₹271/Respules

Tobamist Respules

Cipla Ltd

₹2668.25/respules

853% costlier

Quick tips

Tobihale 300mg Respules is used for long-term management of chronic lung infections in patients with cystic fibrosis.
This medicine is for inhalation using a nebuliser only. The solution should not be injected or swallowed.
Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using.
Inform your doctor if you experience any hearing loss, sensation of ringing in the ears, or dizziness and unsteadiness.
Your doctor will regularly monitor your kidney function while taking Tobihale 300mg Respules to detect any toxicity.
Can I stop taking Tobihale 300mg Respules when I feel better?
Do not skip any doses and finish the full course of treatment even if you feel better.
Tobihale 300mg Respules may cause damage to cornea on long-term use.
Apply pressure on the corner of the eye (close to the nose) for about 1 minute immediately after instilling the drop.
Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
Stinging sensation may occur for 1-2 mins. Notify your doctor if it persists for longer.
Make sure to use it within 4 weeks of opening the bottle.

Fact Box

Chemical Class

Aminoglycosides

Habit Forming

Therapeutic Class

OPHTHAL OTOLOGICALS

Action Class

Aminoglycosides

Interaction with drugs

Taking Tobihale with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Abacavir

Brand(s): Abamune, A-Bec

Serious

Adefovir

Brand(s): Adesera, Adheb, Adfovir

Serious

Alendronic Acid

Brand(s): Alendrate, Alenost, Aldrofos

Serious

Amphotericin B

Brand(s): Amfocare

Serious

View all interactions

Patient concerns

Lung fibrosis treatment how can improve breathing capacity Lung

Dr. Saurav Arora

Homeopathy

Please elaborate your symptoms, history and treatment taken

Lung fibrosis ptacent pulmonology

Dr. Saurav Arora

Homeopathy

Dear sir with Homeopathy this condition's progress can be minimised and quality of life can be improved. But as it is a chronic disease you need to visit a doctor and take treatment under Supervision

FAQs

Q. How do you give Tobihale 300mg Respules?

Tobihale 300mg Respules is given via a nebulizer for inhalation purpose. Your healthcare provider will teach you the method of taking it. Take it exactly as prescribed by your doctor. Use 2 single containers per day for 28 days. Inhale the contents of 1 container in the morning and one in the evening. After taking it for 28 days, stop for 28 days and then again take the medicine for 28 days. Maintain this 28 days on and 28 days off cycle. Try to keep the 2 doses 12 hours apart. Do not take your dose less than 6 hours apart.

Q. Should Tobihale 300mg Respules be refrigerated?

Yes, Tobihale 300mg Respules inhalation solution should be refrigerated at 2- 8°C/36-46°F. Upon removal from refrigeration or if refrigerator is unavailable, the solution pouches (opened/unopened) should be stored at room temperature (up to 25°C/77°F) for up to 28 days. It should not be exposed to intense light. Not storing it in the refrigerator may darken the medicine. However, color change does not indicate change in quality.

Q. Is Tobihale 300mg Respules bad for kidneys?

Yes, Tobihale 300mg Respules belongs to aminoglycoside class of antibiotic medicine, which may affect the kidney function. However, there is no firm evidence to suggest so. If your kidney function is already impaired, then you should be careful while using Tobihale 300mg Respules. Your doctor will get your kidney function tested before starting Tobihale 300mg Respules and at regular intervals during treatment. Tell your doctor if you experience decreased urination, unusual tiredness or weakness or swelling of the face, arms, hands, feet, ankles, or lower legs.

Q. What is antibiotic resistance? Does this occur with Tobihale 300mg Respules?

Sometimes the bacteria gets modified in your body and the medicine no longer works. This is called drug resistance. Resistance can occur with Tobihale 300mg Respules if it is used inappropriately, for example if you do not adhere to the dose and duration of therapy. It may also occur if you use it for viral and fungal infections instead of bacterial infections. Therefore, it is important that you continue taking Tobihale 300mg Respules for the duration advised by your doctor even if you start feeling better.

Q. Can I take other inhaler medicines along with Tobihale 300mg Respules?

Yes, you can take other inhaler medicines along with Tobihale 300mg Respules but not simultaneously. If you are receiving several respiratory therapies, it is recommended that you adhere to the following order: bronchodilator, respiratory physiotherapy, other inhaled medicinal products and finally Tobihale 300mg Respules. You should not mix other inhalation medicinal products with Tobihale 300mg Respules. You should consult your doctor who will let you know when to take which medicine.

Q. Is Tobihale 300mg Respules effective?

Tobihale 300mg Respules is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Tobihale 300mg Respules too early, the symptoms may return or worsen.

Q. What if I don't get better after using Tobihale 300mg Respules?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform the doctor if your symptoms are getting worse while using this medicine.

Q. Can I stop using Tobihale 300mg Respules when I feel better?

No, do not stop taking Tobihale 300mg Respules without consulting your doctor even if you are feeling better. Your symptoms may improve before the infection is completely cured. Therefore, for better and complete treatment, it is advised to continue your treatment for the prescribed duration.

Q. Does Tobihale 300mg Respules have a steroid in it?

No, Tobihale 300mg Respules alone does not have steroids in it. It is an antibiotic, which means that it is effective against bacterial infections. It is not effective against viral or fungal infections and hence should not be used in these kinds of infections. Tobihale 300mg Respules may be combined with steroids such as dexamethasone.

Q. What bacteria does Tobihale 300mg Respules kill?

Tobihale 300mg Respules is effective against a wide range of bacteria. Tobihale 300mg Respules must be used only against susceptible bacteria. A whole gamut of bacteria that can be killed by Tobihale 300mg Respules includes S. Aureus and S. epidermidis, some species of Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenza, and H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, and some Neisseria species. Your doctor will evaluate whether this medicine is suitable for your condition.

Q. How long should you use Tobihale 300mg Respules?

The doctor will decide the duration of treatment which will depend on the severity of infection. For instance, if you have mild to moderate eye infection, your doctor will advise 1-2 eye drops, 4 times a day, usually. In severe infections, you may be prescribed 2 drops every hour. Do not use more or less of it or use it more often than prescribed by your doctor. You should use it exactly as prescribed by your doctor.

Q. How should Tobihale 300mg Respules be used?

You should wash your hands before using the eye drops. Avoid touching the dropper tip against your eye or anywhere else. Tilt your head slightly and instill one drop. Close your eyes for 2 or 3 minutes with your head tipped down, avoid blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct. If you use more than one drop, wait about 5 minutes between the drops. Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

MacDougall C, Chambers HF. Aminoglycosides. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1516.
Chambers HF, Deck DH. Aminoglycosides & Spectinomycin. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 812.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1371-72.
Tobramycin. Netherlands: Sun Pharmaceutical Industries; 2017. [Accessed 31 Mar. 2019] (online) Available from:
Drugs.com. Tobramycin Pregnancy and Breastfeeding Warnings. [Accessed 31 Mar. 2019] (online) Available from:

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