Synate 25mg Injection

Fluphenazine (25mg)

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Synate 25mg Injection is used in the treatment of schizophrenia. It may also be used to treat depression and bipolar disorder. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 29 Apr 2026 | 01:02 PM (IST)

₹21.4 MRP ₹23.449% off

Gurgaon

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General Information

Contains

Fluphenazine (25mg)

Marketer

SPM Drugs Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Synate 25mg Injection is given as an injection under the supervision of a healthcare professional and should not be self-administered. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this injection include dry mouth, abnormality of voluntary movements, urinary retention, constipation, and muscle rigidity. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine can lead to weight gain, have a healthy balanced diet, and exercise regularly. You may also notice some injection site reactions such as pain, redness, or swelling. However, these are temporary and usually resolve on their own in some time. Please consult your doctor in case these do not subside or bother you.

Before taking it, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson’s disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.

Uses of Synate Injection

Benefits of Synate Injection

Treatment of Depression
Synate 25mg Injection helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. This improves your mood, relieves anxiety, tension, helps you sleep better, and increases your energy levels. Synate 25mg Injection prevents extreme mood changes and helps you feel less agitated. You may experience fewer episodes of depression and low mood.

Treatment of Bipolar disorder
Synate 25mg Injection works to restore the normal balance of nerve activity in your brain. It can help prevent extreme changes in mood and help you feel less agitated. You may experience fewer episodes of low mood. It can take several weeks for this medicine to work and you may still feel low during this time. You should continue to eat well and keep fit to reduce symptoms of bipolar disorder.

Side effects of Synate Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Synate

Dystonia (involuntary muscle contractions)
Akathisia (inability to stay still)
Pseudoparkinsonism
Involuntary muscle movement
Oculogyric episodes
Opisthotonos
Increased reflexes
Injection site reactions (pain, swelling, redness)

How to use Synate Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Synate Injection works

Synate 25mg Injection is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.

All substitutes for Synate 25mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Phenate 25mg Injection

by Mesmer Pharmaceuticals

₹58.92/injection

151% costlier

Phenasol 25mg Injection

by Oxpro Pharma Private Limited

₹52.31/injection

123% costlier

Quick tips

It makes you feel sleepy. Do not drive or do anything requiring mental focus until you know how it affects you.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Synate 25mg Injection.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Synate 25mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Synate 25mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
If Synate 25mg Injection is given, monitor the baby for excessive sleepiness.

Driving

UNSAFE

Synate 25mg Injection may cause side effects that could affect your ability to drive.
Caution is advised when driving or operating machinery.

Kidney

CAUTION

Synate 25mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Synate 25mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Synate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Iopamidol (Injection Route)

Do not consume Fluphenazine 48 hours before and At least 12 hours after consuming Iopamidol.

Life-threatening

Iohexol (Injection Route)

Do not consume Fluphenazine 48 hours before and At least 24 hours after consuming Iohexol.

Severe

Lithium carbonate (Oral Route)

If concurrent use is essential, watch out for symptoms such as double vision, weakness, dizziness, impaired coordination, or confusion and consult your doctor if you experience them. Your doctor may monitor your ECG frequently and discontinue the medicines if required. Fluphenazine may raise blood levels of Lithium carbonate and its active form.

Severe

Moxifloxacin (Oral Route)

Do not consume Fluphenazine with Moxifloxacin.

Severe

Moxifloxacin (Injection Route)

Do not consume Fluphenazine with Moxifloxacin.

Frequently asked questions

What is Synate 25mg Injection used for?

Synate 25mg Injection is a long-acting antipsychotic medicine generally used to help manage symptoms of long-term mental health conditions like chronic schizophrenia. It is given when a person needs ongoing, regular treatment rather than daily medicines.

Is Synate 25mg Injection safe for older adults with dementia-related behavior problems?

Who should not take Synate 25mg Injection?

Individuals should not receive Synate 25mg Injection if they are in a coma, or severely sedated, have serious liver disease, or blood disorders, have severe brain injury, are taking large amounts of sleep medicines, or are allergic to fluphenazine or other phenothiazine medicines. It is also not recommended for children under 12 years.

Can Synate 25mg Injection cause long-term movement problems?

Yes. A serious condition called tardive dyskinesia may occur after receiving Synate 25mg Injection, causing uncontrolled movements often of the mouth, tongue, or body. These movements may be permanent. The risk is higher with long-term treatment or higher doses, especially in older adults.

What serious reactions should I watch for after getting Synate 25mg Injection?

Seek urgent medical help if you experience very high fever, stiff muscles, confusion,, or fast heartbeat (possible neuroleptic malignant syndrome), signs of infection like fever or sore throat (possible low white blood cells), severe muscle rigidity or tremors, fainting or severe dizziness, trouble breathing,, and yellowing of the skin/eyes (liver problems). These could be signs of serious reactions.

Can Synate 25mg Injection increase my risk of falls?

Yes. Synate 25mg Injection may cause dizziness, sleepiness, or blood pressure drops, especially when standing up, making falls more likely. People who are older or already unsteady need extra caution.

I have a history of seizures. Is Synate 25mg Injection safe for me?

Use Synate 25mg Injection with caution if you have a history of seizures. Synate 25mg Injection may increase the chance of seizures in people with a history of convulsions. Make sure your doctor knows your full medical history.

I have heart problems. Should I be careful with Synate 25mg Injection?

Yes. People with heart conditions (like mitral valve problems) should use Synate 25mg Injection carefully. The medicine can affect blood pressure and cause changes that may worsen heart-related issues.

Can Synate 25mg Injection affect my blood counts?

Yes. Synate 25mg Injection can sometimes cause low white blood cell counts, which can make it harder for your body to fight infections. Your doctor may order regular blood tests, especially in the first few months.

Can Synate 25mg Injection worsen liver problems?

Yes. People with liver damage should not use Synate 25mg Injection. It may also cause new liver issues in rare cases. Symptoms can include fatigue, stomach pain, dark urine, or yellow skin/eyes.

Fact Box

Chemical Class

Phenothiazines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Typical Antipsychotics

References

Stahl SM, editor. Fluphenazine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 259-63.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 572-73.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Fluphenazine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: SPM Drugs Pvt Ltd
Address: SF 52/1 Main Road, K.R.Palayam, Bhavani Pincode - 638 301, Tamil Nadu, India.

Vendor Details

Country of origin: India

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Synate 25mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Synate Injection

Benefits of Synate Injection

Side effects of Synate Injection

How to use Synate Injection

How Synate Injection works

All substitutes for Synate 25mg Injection

Phenate 25mg Injection

Phenasol 25mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Iopamidol (Injection Route)

Iohexol (Injection Route)

Lithium carbonate (Oral Route)

Moxifloxacin (Oral Route)

Moxifloxacin (Injection Route)

Frequently asked questions

What is Synate 25mg Injection used for?

Is Synate 25mg Injection safe for older adults with dementia-related behavior problems?

Who should not take Synate 25mg Injection?

Can Synate 25mg Injection cause long-term movement problems?

What serious reactions should I watch for after getting Synate 25mg Injection?

Can Synate 25mg Injection increase my risk of falls?

I have a history of seizures. Is Synate 25mg Injection safe for me?

I have heart problems. Should I be careful with Synate 25mg Injection?

Can Synate 25mg Injection affect my blood counts?

Can Synate 25mg Injection worsen liver problems?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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