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Sobisafe 1000 Tablet

Sodium Bicarbonate (1000mg)
Genuine
Authenticity Assured
Prescription
required
Sobisafe 1000 Tablet is used for the management of metabolic acidosis associated with conditions such as chronic kidney disease (CKD), acute renal failure, diabetic ketoacidosis, severe diarrhea, or shock. It helps delay CKD progression and improve overall survival.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
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General Information

Contains

Sodium Bicarbonate (1000mg)

Marketer

Repens Healthcare India Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Sobisafe 1000 Tablet image
Sobisafe 1000 Tablet image

Product introduction

Sobisafe 1000 Tablet relieves irritation by producing carbon dioxide, which neutralizes the acid present in the stomach. It also increases the pH of blood and urine, thereby correcting acid indigestion, heartburn. Additionally, it helps in the removal of toxic substances from the body in certain types of poisoning.


Sobisafe 1000 Tablet may be taken with or without food in a dose and duration as advised by the doctor. Excessive intake may cause an electrolyte imbalance, leading to unwanted side effects. Keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back and your condition may worsen.


Common side effects of this medicine include high sodium levels, cerebral edema, alkalosis, and hypokalemia. Let your doctor know if any of these side effects persist or get worse. They may be able to help by adjusting the dosage or by prescribing you an alternate medicine.


It is important to consult a doctor before taking Sobisafe 1000 Tablet if you are suffering from stomach and kidney disease. Let your doctor also know about all other medications you are taking, as some may affect, or be affected by, this medicine. Pregnant or breastfeeding women should also consult their doctor before taking this medicine.

Uses of Sobisafe Tablet

  • Management of Metabolic acidosis

Benefits of Sobisafe Tablet

Management of Metabolic acidosis
Sobisafe 1000 Tablet helps manage metabolic acidosis, a condition where the body produces too much acid or cannot remove it effectively, leading to a decrease in blood pH. This often occurs in people with chronic kidney disease, diabetic ketoacidosis, or severe dehydration, and can cause fatigue, shortness of breath, and muscle weakness. Sobisafe 1000 Tablet acts as an alkalinizing agent that neutralizes excess acid and restores the body’s normal pH balance. Correcting this imbalance improves breathing, relieves discomfort related to acid buildup.

Side effects of Sobisafe Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sobisafe
  • Increased sodium level in blood
  • Brain swelling
  • Alkalosis
  • Decreased potassium level in blood

How to use Sobisafe Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sobisafe 1000 Tablet may be taken with or without food.

How Sobisafe Tablet works

Sobisafe 1000 Tablet works primarily by providing a source of bicarbonate ions to the body. Sobisafe 1000 Tablet neutralizes the acidity in the stomach, providing relief from the discomfort of acid reflux or heartburn. It can help temporarily increase the pH of the blood, making it less acidic. This property can be useful in certain medical situations, such as metabolic acidosis, where the body becomes too acidic due to conditions like kidney dysfunction or severe dehydration. Sobisafe 1000 Tablet may also help in cases where the urine needs to be less acidic, such as when trying to promote the excretion of certain drugs or when managing certain urinary tract conditions.

All substitutes for Sobisafe 1000 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Nodosis - DS 1000mg Sodium Bicarbonate Tablet

by Steadfast Medishield Pvt Ltd
₹5.31/tablet
25% cheaper
<h3 class=bodySemiBold>Nodosis - DS 1000mg Sodium Bicarbonate Tablet</h3>

Sobisis Forte Tablet

by La Renon Healthcare Private Limited
₹7.13/tablet
same price
<h3 class=bodySemiBold>Sobisis Forte Tablet</h3>

Sodafix-EC DS Tablet

by Ponoogun Healthcare Pvt Ltd
₹8.39/tablet
18% costlier
<h3 class=bodySemiBold>Sodafix-EC DS Tablet</h3>

Sodanet -DS Tablet

by Septalyst Lifesciences Pvt.Ltd.
₹7.66/tablet
8% costlier
<h3 class=bodySemiBold>Sodanet -DS Tablet</h3>

Sobidoc DS Tablet

by Docxis Lifesciences Pvt Ltd
₹5.55/tablet
22% cheaper
<h3 class=bodySemiBold>Sobidoc DS Tablet</h3>

Quick tips

  • Take Sobisafe 1000 Tablet at least 1 to 2 hours before or after other medications, as it may affect their absorption.
  • Avoid taking it with large meals regularly, as excessive use can lead to rebound acidity.
  • Avoid Sobisafe 1000 Tablet, if you show signs of appendicitis or inflammed bowel (such as lower abdominal pain, cramping, bloating, nausea, vomiting). Please consult your doctor.
  • Do not use it as a long-term solution for heartburn or acidity without medical supervision.
  • Monitor sodium intake if you have high blood pressure, kidney issues, or are on a salt-restricted diet.
  • Dissolve the Sobisafe 1000 Tablet completely in water before consuming to reduce the risk of stomach discomfort.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sobisafe 1000 Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Sobisafe 1000 Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Sobisafe 1000 Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Sobisafe 1000 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Sobisafe 1000 Tablet in patients with kidney disease. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Sobisafe 1000 Tablet in patients with liver disease.

Interaction with drugs

Taking Sobisafe with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Ofloxacin (Oral Route)

To take Ofloxacin, ensure a gap of at least 6 hours before or after taking Sodium Bicarbonate. Sodium Bicarbonate may reduce the efficacy of Ofloxacin.
Moderate

Chloroquine (Oral Route)

Ensure a gap of at least 4 hours between taking Chloroquine and Sodium Bicarbonate.
Moderate

Ursodeoxycholic Acid (Oral Route)

Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Sodium Bicarbonate.
Moderate

Azithromycin (Oral Route)

Do not consume Azithromycin with Sodium Bicarbonate. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Sodium Bicarbonate may reduce blood levels of Azithromycin.
Moderate

Sparfloxacin (Oral Route)

To take Sparfloxacin, ensure a gap of at least 6 hours before or after taking Sodium Bicarbonate. Sodium Bicarbonate may reduce the efficacy of Sparfloxacin.

Frequently asked questions

Medical-grade baking soda (present in Sobisafe 1000 Tablet) includes medical-grade purity and quality control, precise dosing in medical formulations, professional oversight of treatment, and specific medical packaging. However, regular baking soda is mostly used for cooking and baking. It helps the baked product rise and be fluffy. Always use the prescribed form rather than kitchen baking soda.
You can take Sobisafe 1000 Tablet for heartburn when symptoms occur, while for chronic conditions, you should take it as prescribed by your doctor. It is usually taken between meals, and it is better not to take it within 2 hours of other medications. Follow specific instructions for your condition.
You should seek medical attention if you experience serious side effects of Sobisafe 1000 Tablet such as severe stomach pain, swelling of feet or ankles, unusual weakness, slow breathing, and mood changes. These could indicate serious complications.
Individuals should exercise extra caution if they have high blood pressure, heart problems, kidney disease, liver problems, and are on a salt-restricted diet. They should consult their doctor before use.
You should only use Sobisafe 1000 Tablet for long-term use under medical supervision. Regular monitoring may be needed in this case. Blood tests might be required, and dosage may need adjustment over time. Always discuss duration with your doctor.

Fact Box

Chemical Class

Organic carbonic acids

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Antacids

References

  1. McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1069.
  2. Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
  3. Sodium Bicarbonate [Product Information]. Ahmedabad, Gujarat: La Renon Healthcare Provate Limited. [Accessed 01 Aug. 2023]. (online) Available from:
  4. Sodium Bicarbonate [Product Label]. Mehatpur, India: Stanford Laboratories Private Limited. [Accessed 06 Aug. 2023]. (online) Available from:
  5. Leeford: Sodium Bicarbonate [Product Information]. [Accessed 27 Oct. 2025]. (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Repens Healthcare India Pvt Ltd
Address: a wing, 405-b, jaswanti allied business center, kachpada, malad west,, mumbai-64, mumbai, maharashtra 400064

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sobisafe 1000 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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