Serontin Syrup

Ethosuximide (250mg/5ml)

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Serontin Syrup is an anti-epileptic medicine used to treat seizures/epilepsy. It works by slowing down the hyperactivity of the brain and nerves in the brain which cause seizures (fits). It also helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 24 Nov 2025 | 10:37 AM (IST)

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General Information

Contains

Ethosuximide (250mg/5ml)

Marketer

Aci Pharma Pvt Ltd

The content is shown in English

Product introduction

Serontin Syrup may be taken with or without food but try to take it at the same time each day. Follow your doctor’s instructions carefully to get the maximum benefit. The dose will depend on your condition and how you respond to the medicine. Your doctor will advise the right dose for you. You should continue taking it for as long as your doctor has told you to, even if you feel well. If you stop or miss doses your seizures could get worse.

Common side effects of this medicine include dizziness, headache, somnolence, anorexia, diarrhea, gastrointestinal upset, nausea, and vomiting. Side effects are more common during the first few weeks and usually lessen as your body gets used to the medicine. Most do not need medical attention, but some of them can be serious. Let your doctor know if you have any symptoms, there may be ways of preventing or reducing them. A small number of people being treated with this medicine have had thoughts of harming or killing themselves. Contact your doctor if your mood changes for the worse.

Before taking it, you should tell your doctor if you have kidney problems, depression, or suicidal thoughts, and if you are pregnant or planning to become pregnant. You should also not breastfeed while taking this medicine. Additionally, do not drink alcohol or take other medicines that make you sleepy or dizzy while on treatment with this medicine. Drowsiness and dizziness may affect your ability to drive or operate machinery. Your kidney function may need to be tested often while taking this medicine.

Uses of Serontin Syrup

Treatment of Epilepsy/Seizures

Benefits of Serontin Syrup

Treatment of Epilepsy/Seizures
Serontin Syrup slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). Follow your doctor’s instructions carefully to get the maximum benefit.

Side effects of Serontin Syrup

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Serontin

Dizziness
Headache
Weight loss
Diarrhea
Nausea
Vomiting
Loss of appetite
Hiccup
Sleepiness
Gastrointestinal discomfort

How to use Serontin Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Serontin Syrup may be taken with or without food.

How Serontin Syrup works

Serontin Syrup belongs to a class of medicines called anticonvulsants. It works by binding with the T-type voltage-sensitive calcium channels to regulate the entrance for calcium ions in the nerves and brain. In this way, it decreases the hyperactivity of the brain and nerves. Thus, it works on the nervous system to treat seizures (fits).

Quick tips

Take it only as per dose and duration prescribed by your doctor.
It may cause dizziness. Do not drive or do anything that requires mental focus until you know how Serontin Syrup affects you.
Your doctor may get regular tests done to monitor your kidney function, liver function, and the level of blood cells in your blood.
Inform your doctor if you notice changes in your mood, behavior or if you have suicidal thoughts while taking Serontin Syrup.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Do not stop taking medication suddenly without talking to your doctor as it can worsen the seizures.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Serontin Syrup may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Serontin Syrup during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Serontin Syrup may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Serontin Syrup may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Serontin Syrup should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Serontin Syrup should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Serontin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Orlistat (Oral Route)

Watch out for symptoms such as tremors. seizures or impaired coordination and consult your doctor if you experience them. Your doctor may consider separating the administration of Orlistat and Ethosuximide. Orlistat may reduce efficacy of Ethosuximide.

Moderate

Sevelamer (Oral Route)

To take Ethosuximide, ensure a gap of at least 1 hour before or 3 hours after taking Sevelamer. Your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Clozapine (Oral Route)

Your doctor may monitor your blood cell count and adjust the doses as per the observations.

Moderate

Ritonavir (Oral Route)

If concurrent use is essential, your doctor may monitor Ethosuximide levels along with your overall treatment and adjust the doses as per the observations. Ritonavir may increase the rate of release of Ethosuximide in the blood.

Moderate

Deferiprone (Oral Route)

Do not consume Deferiprone with Ethosuximide. If concurrent use is essential, please consult your doctor. They may monitor your blood cell count frequently.

Frequently asked questions

What is Serontin Syrup used for?

Serontin Syrup is a medicine used to control a specific type of seizure called absence seizures, or petit mal epilepsy. These are brief periods when a person may stop what they are doing and stare blankly for a few seconds. It helps reduce the number of these episodes and improve daily functioning.

What are the serious warning signs I need to watch for while taking Serontin Syrup?

Contact your doctor immediately if you experience symptoms like fever, sore throat, rash, mouth ulcers, bruising, or fatigue while on Serontin Syrup. These may signal blood problems or a severe allergic reaction. Sudden changes in mood, thoughts of self-harm, or new or worsening depression also require urgent medical attention.

Can Serontin Syrup affect my blood or immune system?

Yes. Rarely, Serontin Syrup can cause blood disorders such as low white blood cells or platelets. These conditions can make you more likely to get infections or bleed easily. Your doctor will monitor your blood regularly during treatment.

What is Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), and can Serontin Syrup cause it?

Yes, Serontin Syrup can cause DRESS, a rare but serious allergic reaction that may include fever, rash, swollen glands, or liver and kidney problems. It can occur even if a rash has not appeared yet. If you notice these symptoms, stop taking Serontin Syrup and get medical help right away.

Can Serontin Syrup cause serious skin reactions?

Although rare, Serontin Syrup can cause life-threatening skin conditions like Stevens-Johnson syndrome (SJS). Symptoms include a painful rash, blisters, or peeling skin. Stop taking Serontin Syrup immediately if these appear and seek emergency care.

Can Serontin Syrup affect my mood or cause suicidal thoughts?

Like other anti-seizure medicines, Serontin Syrup may increase the risk of suicidal thoughts or behavior in a small number of people. Tell your doctor right away if you or your loved ones notice new or worsening depression, anxiety, irritability, or unusual mood changes.

Does Serontin Syrup affect the liver or kidneys?

Yes, Serontin Syrup can sometimes cause liver or kidney problems. Signs include yellowing of the skin or eyes, dark urine, swelling, or persistent nausea. Your doctor may perform blood and urine tests regularly to check your liver and kidney health.

Can Serontin Syrup make other types of seizures worse?

In some people who have more than one type of epilepsy, Serontin Syrup may increase grand mal (tonic-clonic) seizures. If your seizures change or worsen after starting the medicine, talk to your doctor right away.

What should I do if I develop a rash or fever while on Serontin Syrup?

A rash or fever can sometimes be the first sign of a serious reaction. Stop taking Serontin Syrup and contact your doctor immediately. Do not wait to see if it goes away on its own.

Fact Box

Chemical Class

Pyrrolidine- 2- ones

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Calcium channel inhibitor (AED)

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Aci Pharma Pvt Ltd
Address: S402a, School Block, Shakarpur, Delhi - 110092

Vendor Details

Country of origin: India

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Serontin Syrup

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General Information

Contains

Marketer

Product introduction

Uses of Serontin Syrup

Benefits of Serontin Syrup

Side effects of Serontin Syrup

How to use Serontin Syrup

How Serontin Syrup works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Orlistat (Oral Route)

Sevelamer (Oral Route)

Clozapine (Oral Route)

Ritonavir (Oral Route)

Deferiprone (Oral Route)

Frequently asked questions

What is Serontin Syrup used for?

What are the serious warning signs I need to watch for while taking Serontin Syrup?

Can Serontin Syrup affect my blood or immune system?

What is Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), and can Serontin Syrup cause it?

Can Serontin Syrup cause serious skin reactions?

Can Serontin Syrup affect my mood or cause suicidal thoughts?

Does Serontin Syrup affect the liver or kidneys?

Can Serontin Syrup make other types of seizures worse?

What should I do if I develop a rash or fever while on Serontin Syrup?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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