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Roxclif 40mg Injection

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Roxclif 40mg Injection is a pain-relieving medicine. It is used in the treatment of moderate to severe pain. It helps to relieve pain and swelling of various conditions related to joints and muscles. It is usually given in cases where oral administration is unsuitable.
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General Information

Contains

Piroxicam (40mg/2ml)

Marketer

Spackle Biotech

Storage

Store below 30°C
The content is shown in English
Roxclif 40mg Injection image
Roxclif 40mg Injection image

Product introduction

Roxclif 40mg Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.

The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), vomiting, stomach pain, indigestion, diarrhea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

This medicine is not recommended for pregnant or breastfeeding women. Pregnant and breastfeeding mothers must consult with their doctors before using the medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

Uses of Roxclif Injection

Benefits of Roxclif Injection

Pain relief
Roxclif 40mg Injection is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis or even after a dental (tooth-related) surgery.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Roxclif Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Roxclif
  • Injection site reactions (pain, swelling, redness)
  • Vomiting
  • Stomach pain
  • Nausea
  • Headache
  • Dizziness

How to use Roxclif Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Roxclif Injection works

Roxclif 40mg Injection is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).

Quick tips

  • Roxclif 40mg Injection helps relieve pain and swelling of various joints and muscles.
  • It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness. 
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Roxclif 40mg Injection.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Roxclif 40mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Roxclif 40mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Roxclif 40mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Roxclif 40mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Roxclif 40mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Roxclif with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.
Severe

Acenocoumarol (Oral Route)

Do not consume Acenocoumarol with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe

Phenindione (Oral Route)

Do not consume Phenindione with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Warfarin (Oral Route)

Do not consume Warfarin with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

Both Roxclif 40mg Injection and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Roxclif 40mg Injection.
Both Roxclif 40mg Injection and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Roxclif 40mg Injection.
Both Roxclif 40mg Injection and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Roxclif 40mg Injection.
Both Roxclif 40mg Injection and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Roxclif 40mg Injection. Ketoprofen gel also showed excellent tolerability.
Roxclif 40mg Injection is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Both Roxclif 40mg Injection and nimesulide are pain killers. However, Roxclif 40mg Injection is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Roxclif 40mg Injection or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Roxclif 40mg Injection.
No. Roxclif 40mg Injection and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
No. Roxclif 40mg Injection should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
Yes. Methocarbamol can be used with Roxclif 40mg Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Yes. Paracetamol can be used with Roxclif 40mg Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Yes. Roxclif 40mg Injection is a non-steroidal anti-inflammatory drug (NSAID).
Roxclif 40mg Injection is a sulphur containing compound. Roxclif 40mg Injection can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
No. Roxclif 40mg Injection is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
No. Roxclif 40mg Injection is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
No. Roxclif 40mg Injection is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
No. Roxclif 40mg Injection is not a medication to control hypertension. It is important to note that Roxclif 40mg Injection decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Roxclif 40mg Injection.
No. Roxclif 40mg Injection should not be combined with Losartan. It is important to note that Roxclif 40mg Injection decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Roxclif 40mg Injection.
No. Roxclif 40mg Injection should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Roxclif 40mg Injection.
Yes. Roxclif 40mg Injection can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Yes, Roxclif 40mg Injection can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Yes. Roxclif 40mg Injection can be combined with beta-cyclodextrin. Research has shown that combining Roxclif 40mg Injection with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Yes. There are alternatives to Roxclif 40mg Injection. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
No. Roxclif 40mg Injection is not a drug to treat allergy. It is a pain killer.
Roxclif 40mg Injection is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
No. Roxclif 40mg Injection is not known to cause high. It is a non-narcotic painkiller.
Roxclif 40mg Injection is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Roxclif 40mg Injection is not approved for the treatment of migraine. Research studies have shown that Roxclif 40mg Injection is effective in significantly decreasing the pain associated with migraine without aura.
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Roxclif 40mg Injection as the cause of back pain can be different for different person.
Yes. Roxclif 40mg Injection can be given for the treatment of acute gout. Research studies have shown Roxclif 40mg Injection to be highly effective in the treatment of acute gout.
Roxclif 40mg Injection in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Roxclif 40mg Injection so taking piroxicam can lead to increased risk of renal failure by many folds.
No. Roxclif 40mg Injection should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Yes. Roxclif 40mg Injection is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
No. Roxclif 40mg Injection should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
No. Roxclif 40mg Injection is contraindicated in cases of active peptic ulcer disease. Roxclif 40mg Injection is known to cause gastric ulceration and bleeding.
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Yes. Roxclif 40mg Injection can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
No. Roxclif 40mg Injection should not be used with diuretics. Roxclif 40mg Injection reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
No. Roxclif 40mg Injection should not be used with lithium. Roxclif 40mg Injection leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
No. Roxclif 40mg Injection should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

Fact Box

Chemical Class

Benzothiazines

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

Non-Selective COX 1 & 2 Inhibitors (Enolic Acid Derivatives)

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
  2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
  4. Pubchem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
  5. ScienceDirect. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
  6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
  8. Piroxicam [Drug Label]. Metro Manila, Philippines: Pfizer, Inc.; 2022. [Accessed 06 Apr. 2024] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Spackle Biotech
Address: SCF 390, First & Second Floor, Motor Market, Manimajra, Chandigarh 160101

Vendor Details

Country of origin: India

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