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Rofmil Tablet is used to prevent chronic obstructive pulmonary disease(COPD), group of lung disorders in which the flow of air to the lungs is blocked and chronic bronchitis. It works by opening the airways and makes breathing easier.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)
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General Information

The content is shown in English
Rofmil Tablet image
Rofmil Tablet image

Product introduction

Rofmil Tablet can be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Do not miss even a single dose, if in any case, you missed a dose, take it as soon as you remember or better to skip the missed dose and continue with regular dosing.  It does not prevent the already started breathing trouble or COPD, hence always carry your medical inhaler with you for an emergency.

The most common side effects of this medicine include headache, weight loss, dizziness, insomnia, and back pain.  If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. To overcome dizziness, you must avoid driving and attention-seeking activity until you do not know how medicine affects you. If you experienced sudden weight loss, then regular weight monitoring is required.

Before taking this medicine, let your doctor if you suffer from depression, or suicidal thoughts, or if you have HIV, multiple sclerosis. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must inform your doctor if you are pregnant or breastfeeding before treatment. 

Benefits of Rofmil Tablet

Treatment of Chronic obstructive pulmonary disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung condition that causes breathing difficulties, frequent coughing, and flare-ups. Rofmil Tablet is used to help reduce inflammation in the lungs and lower the risk of COPD exacerbations. It helps improve lung function, decreases the frequency of flare-ups, and supports easier breathing, contributing to better daily activity levels and quality of life.

Side effects of Rofmil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Rofmil
  • Weight loss
  • Dizziness
  • Insomnia (difficulty in sleeping)
  • Back pain
  • Nausea
  • Diarrhea
  • Decreased appetite
  • Headache
  • Influenza

How to use Rofmil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rofmil Tablet may be taken with or without food.

How Rofmil Tablet works

Rofmil Tablet works by blocking an enzyme in the lungs called phosphodiesterase-4 (PDE4). This helps reduce inflammation and swelling in the airways, making it easier to breathe. It keeps the airways open and prevents flare-ups, and it helps control symptoms of long-term lung disease like COPD.

All substitutes for Rofmil Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Rofmil Tablet is used to treat chronic obstructive pulmonary disease (COPD).
  • It should not be used for sudden attacks of breathlessness (acute bronchospasm).
  • Consult your doctor if you experience unexplained and significant weight loss while on treatment.
  • Avoid smoking and minimise your exposure to pollution, dust, and fumes. Along with that, a little exercise each day can help you stay strong.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Rofmil Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Rofmil Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Rofmil Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

SAFE
Rofmil Tablet does not usually affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Rofmil Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

UNSAFE
Rofmil Tablet is unsafe to use in patients with liver disease and should be avoided.
Use of Rofmil Tablet is not recommended in patients with moderate to severe liver disease.

Interaction with drugs

Taking Rofmil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Aminophylline (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your blood sugar level. Aminophylline may reduce blood levels of the active form of Roflumilast.
Moderate

Aminophylline (Injection Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your blood sugar level. Aminophylline may reduce blood levels of the active form of Roflumilast.
Moderate

Carbamazepine (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Carbamazepine may reduce blood levels and efficacy of Roflumilast.
Moderate

Cimetidine (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Cimetidine may reduce blood levels of Roflumilast and its active form.
Moderate

Ciprofloxacin (Oral Route)

Watch out for symptoms such as diarrhea, nausea or headaches and consult your doctor if you experience them. They may adjust the dose of Roflumilast accordingly. Ciprofloxacin may raise blood levels of Roflumilast.

Frequently asked questions

No. Rofmil Tablet is not a methylxanthine and works via a different mechanism of action
Yes. Rofmil Tablet is available in India in the form of 500 mcg tablet
No. Rofmil Tablet belongs to a class of drugs called phosphodiesterase inhibitors. It does not have a chemical structure or effects similar to steroids. It does not induce sleep and is not a narcotic drug
Rofmil Tablet is used as a maintenance treatment for severe chronic obstructive pulmonary disease (COPD; a group of lung disorders in which the flow of air to the lungs is blocked) in patients with frequent worsening of COPD symptoms (COPD exacerbations) and with long-term inflammation of airways (chronic bronchitis)
Rofmil Tablet is used to prevent worsening of symptoms in patients with severe chronic obstructive pulmonary disease (COPD; a group of lung disorders in which the flow of air to the lungs is blocked) and long-term inflammation of airways (chronic bronchitis)
Rofmil Tablet may need to be taken for several weeks to achieve its effects and may vary upon individual response. Please follow advice of your doctor regarding dose and duration.

Fact Box

Chemical Class

Benzamide derivative

Habit Forming

No

Therapeutic Class

RESPIRATORY

Action Class

Phosphodiesterase-IV Inhibitors (COPD)
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User feedback

Once A Day
92%
Twice A Day
8%
Chronic obstructive pulmonary disease (COPD)
70%
Asthma
20%
Others
10%
Average
56%
Excellent
22%
Poor
22%
Weight loss
50%
No Side Effect
50%
With food
100%
Expensive
78%
Average
22%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
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