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Roflumilast

INFORMATION

Uses

Roflumilast is used to prevent asthma and chronic obstructive pulmonary disorder (COPD).

How it works

Roflumilast belongs to a class of drugs called phosphodiesterase inhibitors. It works by reducing inflammation in the lungs. It also inhibits an enzyme called phosphodiesterase-4 (PDE4) that is involved in triggering inflammation and other changes in the lungs which leads to the development of COPD symptoms.

Common side effects

Nausea, Anxiety, Back pain, Diarrhoea, Dizziness, Headache, Influenza, Loss of appetite, Muscle cramp, Tremor

AVAILABLE MEDICINE

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Expert advice

  • Roflumilast is not effective and should not be used for sudden attacks of breathlessness (acute bronchospasm).
  • You should not take roflumilast if you have a history of depression and suicidal behavior/thoughts.
  • You should have your weight monitored regularly. Stop taking roflumilast and seek advice if you experience unexplained and significant weight loss while on treatment.
  • Roflumilast controls COPD but does not cure it. It is important to continue taking roflumilast even if you feel well unless advised otherwise.
  • Roflumilast may cause dizziness, which can aggravate with alcohol intake. Do not drive or operate any machinery until you feel fine.
  • You should not take roflumilast if you have any serious disease affecting your immune system (HIV, multiple sclerosis, lupus erythematosus, progressive multifocal leukoencephalopathy) or if you are receiving treatments that act on your immune system for certain cancers or serious infections.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions

Roflumilast

Q.Is Roflumilast a methylxanthine?
No. Roflumilast is not a methylxanthine and works via a different mechanism of action

Q.Is roflumilast available in India?
Yes. Roflumilast is available in India in the form of 500 mcg tablet

Q.Is roflumilast a steroid/ narcotic?
No. Roflumilast belongs to a class of drugs called phosphodiesterase inhibitors. It does not have a chemical structure or effects similar to steroids. It does not induce sleep and is not a narcotic drug

Q.What is roflumilast used for?
Roflumilast is used as a maintenance treatment for severe chronic obstructive pulmonary disease (COPD; a group of lung disorders in which the flow of air to the lungs is blocked) in patients with frequent worsening of COPD symptoms (COPD exacerbations) and with long-term inflammation of airways (chronic bronchitis)

Q.How does roflumilast work?
Roflumilast is used to prevent worsening of symptoms in patients with severe chronic obstructive pulmonary disease (COPD; a group of lung disorders in which the flow of air to the lungs is blocked) and long-term inflammation of airways (chronic bronchitis)

Q.How long does roflumilast take to work?
Roflumilast may need to be taken for several weeks to achieve its effects and may vary upon individual response. Please follow advice of your doctor regarding dose and duration.


Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)