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Rifaximax 400 Tablet

Rifaximin (400mg)

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Product Summary :

Rifaximax 400 Tablet is an antibiotic that contains rifaximin, used to treat hepatic encephalopathy in adults with liver disease. It works by stopping the growth of certain bacteria in the intestine. Take Rifaximax 400 Tablet in the dose and for the duration prescribed by your doctor. You can take it with or without food. Common side effects may include nausea, dizziness, and abdominal discomfort. Inform your doctor about all the medicines you are taking, particularly cyclosporine or warfarin. Seek medical attention if you develop severe or persistent diarrhea, especially with blood in the stools or fever.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 29 Oct 2026 | 01:03 AM (IST)

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General Information

Contains

Rifaximin (400mg)

Marketer

Zuventus Healthcare Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Rifaximax 400 Tablet is an antibiotic that treats hepatic encephalopathy, a condition in which the liver fails to remove harmful toxins from the blood, leading to brain damage. It works by killing and stopping the growth of harmful bacteria in the intestines.

This medicine can be used alone or in combination with other medicines. It may be taken with or without food, preferably at the same time each day. It should be used in the dose and duration as advised by the doctor. Take it at the same time each day to get the most benefit, and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection come back and be harder to treat.

Some people may develop side effects like peripheral edema, nausea, constipation, dizziness, fatigue, urinary tract infection, and insomnia. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Your urine may become reddish in color due to this medicine. But it is normal and harmless.

Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding, or suffering from any liver, kidney, or heart problems, or if you are allergic to any medicine.

Uses of Rifaximax Tablet

Treatment of Hepatic encephalopathy

Benefits of Rifaximax Tablet

Treatment of Hepatic encephalopathy
Hepatic encephalopathy is a severe liver disease that can cause changes in brain function, leading to confusion, tremors (shaking), sleep problems, and loss of consciousness. Symptoms include agitation, confusion, muscle problems, difficulty in speaking, and sometimes coma. Rifaximax 400 Tablet lowers the levels of ammonia-producing bacteria in the blood, which has harmful effects on the brain. If taken as prescribed, this medicine can improve your brain function and reduce symptoms associated with hepatic encephalopathy.

Side effects of Rifaximax Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Rifaximax

Peripheral edema
Dizziness
Fatigue
Urinary tract infection
Insomnia (difficulty in sleeping)
Nausea
Constipation
Anemia (low number of red blood cells)
Itching
Ascites (accumulation of fluid in the abdominal cavity)

How to use Rifaximax Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rifaximax 400 Tablet may be taken with or without food.

How Rifaximax Tablet works

Rifaximax 400 Tablet is an antibiotic. It works by killing the ammonia-producing bacteria in the digestive tract. This treats your infection and relieves symptoms of hepatic encephalopathy (agitation, confusion, muscle problems). This also helps reduce the recurrence of episodes of hepatic encephalopathy.

Dosage

The dose and duration of treatment with Rifaximax 400 Tablet depend on the severity of your condition and your response to treatment. Take the medicine exactly as prescribed by your doctor, with or without food, and do not change the dose or stop treatment without medical advice.

All substitutes for Rifaximax 400 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Rifaximax 400 Tablet reduces the risk of overt hepatic encephalopathy (HE) recurrence in patients with liver disease.
It may cause reddish discoloration of urine. This is normal and harmless.
Stop taking Rifaximax 400 Tablet and inform your doctor if you have severe diarrhea during or after using Rifaximax 400 Tablet.
Finish the full course of the medication, even if you feel better.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Rifaximax 400 Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Rifaximax 400 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Rifaximax 400 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Rifaximax 400 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Rifaximax 400 Tablet in patients with kidney disease. Please consult your doctor.

Liver

CAUTION

Rifaximax 400 Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Rifaximax with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Erythromycin (Oral Route)

watch out for symptoms of Rifaximin side effects such as diarrhea, dizziness, swelling or fatigue and consult your doctor if you experience them. They may adjust the doses as per the observations. Erythromycin may raise blood levels of Rifaximin.

Moderate

Erythromycin (Oral Route)

Moderate

Indinavir (Oral Route)

Moderate

Amiodarone (Oral Route)

Moderate

Amiodarone (Injection Route)

Frequently asked questions

Should I take Rifaximax 400 Tablet with food?

Yes, Rifaximax 400 Tablet can be taken orally with or without food with a glass of water. Take it as prescribed by your doctor for the exact period of time.

What does Rifaximax 400 Tablet do for the liver?

In liver disease, there is an increased growth of bacteria in the intestine which increases the load of toxins travelling through the body. This further increases the possibility of toxins reaching the brain which can cause abnormal brain function. Rifaximax 400 Tablet slows down the growth of bacteria in the gut, decreasing the symptoms in cases of liver disease.

Can Rifaximax 400 Tablet cause weight gain?

Usually Rifaximax 400 Tablet does not cause weight gain. However, in case you feel there is an increase in weight, you should consult your doctor to determine the reason of weight gain.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

RNA polymerase inhibitors- Rifamycins

Related lab tests

Ammonia

Liver Function Test

Potassium

Sodium

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1215-16.
Rifaximin [Package Insert]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2015. [Accessed 05 Aug. 2023] (online) Available from:
CiplaMed. Rifaximin [Prescribing Information]. [Accessed 05 Aug. 2023] (online) Available from:
Rifaximin [EMC Label]. Uxbridge, UK: Norgine Pharmaceuticals Ltd.; 2025 [Accessed 16 Feb. 2026] (online). Available from:

User feedback

Patients taking Rifaximax 400 Tablet

Twice A Day

64%

Thrice A Day

22%

Once A Day

10%

Alternate Day

What are you using Rifaximax Tablet for?

Hepatic encephalopathy

42%

Others

33%

Infectious diarrhea

17%

Diarrhea

How much was the improvement?

Excellent

67%

Average

33%

What were the side-effects while using Rifaximax 400 Tablet?

Headache

50%

No Side Effect

50%

How do you take Rifaximax Tablet?

With food

100%

Please rate Rifaximax 400 Tablet on price

Average

100%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zuventus Healthcare Ltd
Address: Office No. 5119, 5th Floor, 'D' Wing, Oberoi Garden Estates, Chandivili, Andheri (E), Mumbai - 400 072.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Rifaximax 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Rifaximax 400 Tablet

Rifaximax 400 Tablet

Product Summary :

Payment, Returns & Expiry

Cash on delivery available

7 day free return

Product expires after Aug, 2028

Price Info

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Rifaximax Tablet

Benefits of Rifaximax Tablet

Side effects of Rifaximax Tablet

How to use Rifaximax Tablet

How Rifaximax Tablet works

Dosage

All substitutes for Rifaximax 400 Tablet

Rexigut 400mg Tablet

Rifaford 400mg Tablet

Rifagut 400 Tablet

Rcifax 400 Tablet

Rifastop 400 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Erythromycin (Oral Route)

Erythromycin (Oral Route)

Indinavir (Oral Route)

Amiodarone (Oral Route)

Amiodarone (Injection Route)

Frequently asked questions

Should I take Rifaximax 400 Tablet with food?

What does Rifaximax 400 Tablet do for the liver?

Can Rifaximax 400 Tablet cause weight gain?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Ammonia

Liver Function Test

Potassium

Sodium

References

User feedback

Patients taking Rifaximax 400 Tablet

What are you using Rifaximax Tablet for?

How much was the improvement?

What were the side-effects while using Rifaximax 400 Tablet?

How do you take Rifaximax Tablet?

Please rate Rifaximax 400 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

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