Prokine 5mg Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 31 Mar 2026 | 02:28 PM (IST)

Prokine 5mg Tablet is a prescription medicine used in the treatment of gastroesophageal reflux disease (acid reflux) and constipation. It helps to increase gastric emptying of both liquids and solids.

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General Information

Contains

Cisapride (5mg)

Marketer

RPG Life Sciences Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Prokine 5mg Tablet is taken before meals or at bedtime in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are headache and nausea. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine may cause diarrhea, so its better to take plenty of fluids while taking this medicine as it may help to prevent dehydration. It may cause also dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Pregnant or breastfeeding women should also consult their doctor. Before taking this medicine, you should let your doctor know if you have heart disease, drink a lot of alcohol or have liver, or heart problems.

Uses of Prokine Tablet

Benefits of Prokine Tablet

Gastroesophageal reflux disease (Acid reflux)
Gastroesophageal reflux disease (GERD) is a chronic (long-term) condition which is like having heartburn consistently rather than just occasionally. It happens because a muscle above your stomach relaxes too much and allows stomach contents to come back up into your oesophagus and mouth. Prokine 5mg Tablet reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective.
Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3-4 hours of going to bed.

Side effects of Prokine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Prokine

Headache
Nausea
Diarrhea

How to use Prokine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prokine 5mg Tablet is to be taken on an empty stomach.

How Prokine Tablet works

Prokine 5mg Tablet indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.

Quick tips

It is usually taken around 15 minutes before food or bedtime.
Do not skip any dose and finish the complete course even if you feel better.
Use caution while driving or doing anything that requires concentration as Prokine 5mg Tablet can cause dizziness and sleepiness.
It may cause diarrhea. Drink plenty of fluids to avoid dehydration while taking this medicine.
Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Prokine 5mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Prokine 5mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Prokine 5mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Prokine 5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Prokine 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Prokine 5mg Tablet in patients with liver disease.

Interaction with drugs

Taking Prokine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Acenocoumarol (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Acenocoumarol may reduce blood levels of Cisapride.

Moderate

Ciclosporin (Oral Route)

Caution is advised when taking Cisapride with Ciclosporin. Your doctor may closely monitor the effects of Ciclosporin if used concurrently with Cisapride and adjust the dose if needed. Cisapride may raise blood levels of Ciclosporin.

Moderate

Ciclosporin (Injection Route)

Moderate

Nifedipine (Oral Route)

If concurrent use is essential, please consult your doctor. They may monitor your blood pressure frequently. Cisapride may raise blood levels of the active form of Nifedipine.

Moderate

Simvastatin (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Simvastatin may raise blood levels of Cisapride.

Frequently asked questions

Why is Prokine 5mg Tablet banned?

This medicine is banned for sale because it may cause serious irregular heartbeats, which can lead to death.

What was Prokine 5mg Tablet used for?

Before getting banned, this medicine was used to treat heartburn in patients with gastroesophageal reflux disease (GERD).

What is gastroesophageal reflux disease or GERD?

Gastroesophageal reflux disease (GERD) is a condition in which the stomach's contents sometimes flow backward, up into the esophagus (the tube that carries food from your throat into your stomach). As a result, you may experience a burning sensation in your chest, pain in your chest, trouble swallowing, or a sore throat.

Fact Box

Chemical Class

Aminobenzamides

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Serotonin 5-HT4 Receptor Antagonists- Prokinetic Agents

Related lab tests

Complete Blood Count

References

Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1326-27.
Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 284.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 28 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: RPG Life Sciences Ltd
Address: 463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Prokine 5mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Prokine Tablet

Benefits of Prokine Tablet

Side effects of Prokine Tablet

How to use Prokine Tablet

How Prokine Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Acenocoumarol (Oral Route)

Ciclosporin (Oral Route)

Ciclosporin (Injection Route)

Nifedipine (Oral Route)

Simvastatin (Oral Route)

Frequently asked questions

Why is Prokine 5mg Tablet banned?

What was Prokine 5mg Tablet used for?

What is gastroesophageal reflux disease or GERD?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests