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Pramirol 0.125 Tablet

Pramipexole (0.125mg)

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Pramirol 0.125 Tablet is used in the treatment of Parkinson's disease and restless leg syndrome (an urge to move the legs usually accompanied or caused by uncomfortable and unpleasant leg sensations). It helps to treat excessive shaking by slowing down the body movements.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)

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General Information

Contains

Pramipexole (0.125mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Pramirol 0.125 Tablet can be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. You should never skip any doses and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to your doctor.

Some common side effects of this medicine include nausea, dry mouth, fatigue, hallucinations, constipation, and peripheral edema. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, an urge to gamble, or uncontrolled spending as these may prove very harmful.

Before you start Pramirol 0.125 Tablet, let your doctor know if you have any medical conditions. Inform your doctor about all the medications you are taking, as some medicines may interact with Pramirol 0.125 Tablet. Pregnant or breastfeeding women should consult their doctor before taking Pramirol 0.125 Tablet to ensure safety.

Uses of Pramirol Tablet

Benefits of Pramirol Tablet

Parkinson's disease
Pramirol 0.125 Tablet is used to help manage symptoms such as tremors, stiffness, and slowed movement in Parkinson’s disease, supporting better mobility and daily functioning.

Restless leg syndrome
In rest leg syndrome, Pramirol 0.125 Tablet helps relieve the uncomfortable urge to move the legs, especially at night, leading to improved sleep quality and overall comfort.

Side effects of Pramirol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pramirol

Dizziness
Sleepiness
Nausea
Fatigue
Hallucination
Constipation
Weakness
Insomnia (difficulty in sleeping)
Headache

How to use Pramirol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pramirol 0.125 Tablet may be taken with or without food.

How Pramirol Tablet works

Pramirol 0.125 Tablet works by mimicking the action of dopamine, a chemical messenger that is needed to control movement in the brain.

All substitutes for Pramirol 0.125 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed Pramirol 0.125 Tablet to treat your symptoms of Parkinson's disease and/or restless leg syndrome.
It can be taken with or without food. Taking it with food may reduce nausea.
For restless leg syndrome, take this medicine 2 to 3 hours before bedtime.
Avoid activities that require you to be alert, such as driving a car until you know how this medication affects you.
When you first start taking Pramirol 0.125 Tablet, it may cause sudden drop in your blood pressure when you change positions. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Talk to your doctor in case you develop hallucinations or other changes in your behavior.
Inform your doctor if you develop compulsive behaviors that are hard to control, such as binge eating, gambling, spending money, and sexual urges.
Do not stop taking the medication suddenly without talking to your doctor.
You have been prescribed Pramirol 0.125 Tablet to treat your symptoms of Parkinson's disease and/or restless leg syndrome.
It can be taken with or without food. Taking it with food may reduce nausea.
Inform your doctor if you develop compulsive behaviors that are hard to control, such as binge eating, gambling, spending money, and sexual urges.
Avoid activities that require you to be alert, such as driving a car until you know how this medication affects you.
When you first start taking Pramirol 0.125 Tablet, it may cause sudden drop in your blood pressure when you change positions. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Talk to your doctor in case you develop hallucinations or other changes in your behavior.
Do not stop taking the medication suddenly without talking to your doctor.
For restless leg syndrome, take this medicine 2 to 3 hours before bedtime.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Pramirol 0.125 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Pramirol 0.125 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Pramirol 0.125 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Pramirol 0.125 Tablet suppresses serum prolactin and may interfere with breastfeeding.

Driving

UNSAFE

Pramirol 0.125 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Pramirol 0.125 Tablet can cause hallucinations (seeing, hearing or feeling things that are not there). This may affect your ability to drive.

Kidney

CAUTION

Pramirol 0.125 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

SAFE IF PRESCRIBED

Pramirol 0.125 Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Pramirol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Ziprasidone (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Ziprasidone may reduce efficacy of Pramipexole.

Moderate

Loxapine (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Loxapine may block the action of Pramipexole.

Moderate

Amisulpride (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Amisulpride may block the action of Pramipexole.

Moderate

Amisulpride (Injection Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Amisulpride may block the action of Pramipexole.

Moderate

Chlorpromazine (Oral Route)

If concurrent use is essential, please consult your doctor, they may monitor your treatment and adjust the doses as per the observations. Chlorpromazine may block the action of Pramipexole.

Frequently asked questions

Does Pramirol 0.125 Tablet cause weight gain?

A common side effect of Pramirol 0.125 Tablet is decrease in body weight which may be due to decrease in appetite. Uncommonly, it can also cause increase in weight. However, if you have concerns regarding your weight talk to your doctor or a nutritionist.

Does Pramirol 0.125 Tablet make you sleepy?

Yes, Pramirol 0.125 Tablet may cause sleepiness. You may also experience sudden episodes of falling asleep. If it occurs, restrict driving and using heavy machinery and inform your doctor.

How does Pramirol 0.125 Tablet work for restless legs?

Restless leg syndrome (RLS) is a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down. Pramirol 0.125 Tablet belongs to dopamine (neurotransmitter) agonist class of medicines. It acts by stimulating the dopamine receptors which is needed in the brain to control movement. Hence, it is used to improve RLS.

Is Pramirol 0.125 Tablet a muscle relaxant?

No, Pramirol 0.125 Tablet is not a muscle relaxant. It helps in improving movements and muscle control in Parkinson’s disease. It is a dopamine agonist and acts on dopamine receptors.

Can I stop taking Pramirol 0.125 Tablet if my symptoms of Parkinson’s disease have improved?

You should not stop Pramirol 0.125 Tablet without talking to your doctor. Sudden discontinuation of Pramirol 0.125 Tablet may cause neuroleptic malignant syndrome. The symptoms of malignant syndrome include loss of muscle movement, rigid muscles, fever, unstable blood pressure, increased heart rate, confusion, and depressed level of consciousness.

How should Pramirol 0.125 Tablet be taken?

You should take Pramirol 0.125 Tablet as directed by your doctor. The doctor will decide your dose depending on the condition you are being treated for. Preferably it should be taken 2-3 hours before bedtime. Swallow the tablets whole with water. It can be taken with or without food, but taking it with food may help reduce the chances of nausea.

What are the serious side effects of Pramirol 0.125 Tablet?

The serious side effects of Pramirol 0.125 Tablet include hallucinations (seeing things or hearing voices that do not exist), confusion, aggressive behavior, agitation, abnormal thoughts, changes in vision, abnormal body movements, and motions that you cannot control. It may also cause changes in the way you sit or stand that you cannot control, such as your neck bending forward, bending forward at the waist, or tilting sideways when you sit, stand or walk. Additionally, it may cause dark, red or cola-colored urine, muscle tenderness, muscle stiffness or aching and muscle weakness. Call your doctor immediately if you experience any of these.

What are impulse control disorders caused by Pramirol 0.125 Tablet?

Pramirol 0.125 Tablet may cause impulse control disorders in which you may have cravings or urge to behave in an unusual manner, which normally you would not do. Pramirol 0.125 Tablet may also make it hard for you to resist the impulse to carry certain activities which can harm you or others, like addictive gambling, excessive eating or spending money. Along with that, it may cause an abnormally high sex drive or preoccupation with an increase in sexual thoughts or feelings.

Fact Box

Chemical Class

Aralkylamines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Dopamine Agonists

References

Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 475-76.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1140-41.
Pramipexole dihydrochloride. Ridgefield, Connecticut: Boehringer Ingelheim International GmbH; 2010. [Accessed 22 Jan. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 22 Mar. 2019] (online) Available from:
Pramipexole. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd.; 2012 [revised 7 Feb. 2018]. [Accessed 22 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 07 Aug. 2023] (online) Available from:
Pramipexole dihydrochloride [Prescribing Information]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2021. [Accessed 05 Aug. 2023] (online) Available from:
Pramipexole dihydrochloride. Prescribing Information. Bryant Ranch Prepack Inc., Burbank, CA, USA.; 2024. [Accessed 10 Sep. 2025] (online) Available from:
Pramipexole dihydrochloride, Bryant, CA: Bryant Ranch Prepack; 2024. [Accessed 06 Nov. 2025] (online). Available from:

User feedback

Patients taking Pramirol 0.125 Tablet

Once A Day

43%

Thrice A Day

28%

Twice A Day

26%

Once A Week

Alternate Day

What are you using Pramirol Tablet for?

Restless leg syndrome

67%

Parkinson's disease

33%

How much was the improvement?

Excellent

100%

What were the side-effects while using Pramirol 0.125 Tablet?

Dizziness

100%

How do you take Pramirol Tablet?

With food

100%

Please rate Pramirol 0.125 Tablet on price

Average

67%

Expensive

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Pramirol 0.125 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

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Pramirol 0.125 Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Pramirol Tablet

Benefits of Pramirol Tablet

Side effects of Pramirol Tablet

How to use Pramirol Tablet

How Pramirol Tablet works

All substitutes for Pramirol 0.125 Tablet

Pramipex 0.125 Tablet

Pexopram 0.125mg Tablet

Mirator 0.125 Tablet

Prexol 0.125mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ziprasidone (Oral Route)

Loxapine (Oral Route)

Amisulpride (Oral Route)

Amisulpride (Injection Route)

Chlorpromazine (Oral Route)

Frequently asked questions

Does Pramirol 0.125 Tablet cause weight gain?

Does Pramirol 0.125 Tablet make you sleepy?

How does Pramirol 0.125 Tablet work for restless legs?

Is Pramirol 0.125 Tablet a muscle relaxant?

Can I stop taking Pramirol 0.125 Tablet if my symptoms of Parkinson’s disease have improved?

How should Pramirol 0.125 Tablet be taken?

What are the serious side effects of Pramirol 0.125 Tablet?

What are impulse control disorders caused by Pramirol 0.125 Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Pramirol 0.125 Tablet

What are you using Pramirol Tablet for?

How much was the improvement?

What were the side-effects while using Pramirol 0.125 Tablet?

How do you take Pramirol Tablet?

Please rate Pramirol 0.125 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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