Polo 40mg Injection

Olanzapine (40mg)

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Polo 40mg Injection is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 31 Mar 2026 | 02:31 PM (IST)

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General Information

Contains

Olanzapine (40mg)

Marketer

Total Healthcare

Storage

Store below 30°C

The content is shown in English

Product introduction

Polo 40mg Injection is generally administered by a doctor or a nurse, typically in a hospital or clinical setting. Make sure to follow all your doctor’s instructions. Get the injection in the dose and duration as advised by your doctor. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.

Some common side effects of this medicine include dryness in the mouth, increased appetite, sleepiness, hard or infrequent stools, and restlessness. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it is better to rise slowly if you have been sitting or lying down. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

However, this medicine may increase your weight, blood sugar, and cholesterol levels, but modifying your lifestyle by having a healthy diet and exercising regularly can reduce these side effects. You should be cautious, as in rare cases it may cause serious side effects like very high blood sugar levels or seizures.

Uses of Polo Injection

Benefits of Polo Injection

Treatment of Mania
Mania means extremely excited or elevated mood. Polo 40mg Injection helps calm the mood and relax the nerves. This stabilises the mood and prevents the symptoms of mania from recurring again. Taking Polo 40mg Injection will ensure that you have a better social life and are able to do daily activities more comfortably.

Schizophrenia
Schizophrenia is a mental disorder in which a person’s thinking ability, feelings and behavior become abnormal. Polo 40mg Injection helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts, behavior and enhances the quality of life.

Side effects of Polo Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Polo

Increased appetite
Increased liver enzymes
Constipation
Extrapyramidal symptoms
Low energy
Weakness
Hard stool
Increased glucose level in blood
Anticholinergic effects
Decreased white blood cell count (neutrophils)
Weight gain
Sleepiness
Dizziness
Increased prolactin level in blood
Altered blood lipid level

How to use Polo Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Polo Injection works

Polo 40mg Injection is an atypical antipsychotic. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts, and behavior. It blocks dopamine (D₂) and serotonin (5-HT₂A) receptors in the brain, helping to balance these chemicals and reduce symptoms of schizophrenia and mania. Additionally, it interacts with other receptors, such as histamine and adrenergic receptors, which may contribute to its sedative effects.

Quick tips

Polo 40mg Injection is less likely to cause heart and movement problems as compared to other similar medicines.
Use caution while driving or doing anything that requires concentration, as Polo 40mg Injection can cause dizziness and sleepiness.
Polo 40mg Injection may increase your weight, blood sugar, and cholesterol. Eat healthy, exercise regularly, and monitor your blood levels regularly.
To lower the chance of feeling dizzy, rise slowly if you have been sitting or lying down.
Do not stop taking Polo 40mg Injection without talking to your doctor first, as it may cause worsening of symptoms.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Polo 40mg Injection.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Polo 40mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Polo 40mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Polo 40mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Polo 40mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Polo 40mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Polo with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Olanzapine.

Severe

Amiodarone (Oral Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Severe

Haloperidol (Oral Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Severe

Haloperidol (Injection Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Severe

Pimozide (Oral Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Frequently asked questions

Can Polo 40mg Injection be used for anxiety?

The treatment of anxiety with Polo 40mg Injection is not an approved indication. Polo 40mg Injection has been studied for the treatment of anxiety disorders, but the results have not been very convincing. However, it can be used along with anxiolytics in anxiety disorders for better results.

Is Polo 40mg Injection a sleeping pill?

No, Polo 40mg Injection is not a sleeping pill. It belongs to the atypical antipsychotic class of medicines. It is used to treat schizophrenia and mania.

Can Polo 40mg Injection be taken during pregnancy?

Polo 40mg Injection should be avoided during pregnancy and should only be given if the benefits outweigh the risks. Using Polo 40mg Injection during the last 3 months of pregnancy may cause unwanted symptoms in the unborn baby. These symptoms include shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty feeding.

Can I stop taking Polo 40mg Injection if I feel better?

You should not stop taking Polo 40mg Injection without consulting your doctor. This is because sudden discontinuation of the medicine may cause unpleasant side effects, which include sweating, unable to sleep, tremors, anxiety or nausea, and vomiting. To avoid such effects, your doctor will reduce the dose gradually before stopping the treatment.

Does smoking or alcohol interfere with the working of Polo 40mg Injection?

Yes, smoking interferes with the working of Polo 40mg Injection, causing an increase in its metabolism. One should avoid alcohol while taking Polo 40mg Injection since it may cause more drowsiness. However, if you are a smoker, then your doctor may increase your dose depending on your response to treatment.

Can Polo 40mg Injection be used for anxiety?

The treatment of anxiety with Polo 40mg Injection is not an approved indication. Polo 40mg Injection has been studied for treatment of anxiety disorders but the results have not been very convincing. However, it can be used along with anxiolytics in anxiety disorders for better results.

Is Polo 40mg Injection a sleeping pill?

No, Polo 40mg Injection is not a sleeping pill. It belongs to the atypical antipsychotic class of medicines. It is used to treat schizophrenia. Schizophrenia is a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions. Polo 40mg Injection also helps with bipolar disorder (manic depressive disorder). It is a disease that causes episodes of depression, mania, and other abnormal moods.

How long does it take for Polo 40mg Injection to kick in?

Polo 40mg Injection may start showing initial improvement within 1-2 week of starting. However, for full benefits it may take about 4-6 weeks. You should continue taking it and consult your doctor in case you feel that Polo 40mg Injection is not helping you.

What is the most important information that I should know about Polo 40mg Injection?

Polo 40mg Injection can cause serious side effects which include increased risk of death in elderly people who are confused, have memory loss and have lost touch with reality (dementia-related psychosis). It is important to know that it may increase blood sugar levels in diabetics and also in patients who never had diabetes. Furthermore, it may cause weight gain and high fat levels in the blood which is more common in teenagers.

Can Polo 40mg Injection be taken during pregnancy?

Polo 40mg Injection should be avoided during pregnancy and should only be given if benefits outweigh the risk. Using Polo 40mg Injection during last 3 months of pregnancy may cause unwanted symptoms in the unborn baby. These symptoms include shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding.

Can I stop taking Polo 40mg Injection if I am better?

You should not stop taking Polo 40mg Injection without consulting your doctor. This is because sudden discontinuation of the medicine may cause unpleasant side effects which include sweating, unable to sleep, tremor, anxiety or nausea, and vomiting. To avoid such effects, your doctor will reduce the dose gradually before stopping the treatment.

Does smoking or alcohol interfere with working of Polo 40mg Injection?

Yes, smoking interferes with working of Polo 40mg Injection causing an increase in its metabolism. One should avoid alcohol while taking Polo 40mg Injection since it may cause more drowsiness. However, if you are a smoker then your doctor may increase your dose depending on your response to treatment.

Fact Box

Chemical Class

Benzodiazepines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Atypical Antipsychotics

References

Stahl SM, editor. Olanzapine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 485-92.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1013-16.
Olanzapine. Basingstoke, Hampshire: Eli Lilly and Company Limited; 2013 [revised 22 Nov. 2018]. [Accessed 25 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
Olanzapine [Patient Information Sheet]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2002. [Accessed 28 Mar. 2023] (online) Available from:
Olanzapine [FDA Label]. Indianapolis, IN: Lilly USA, LLC; 2025. [Accessed 10 Mar. 2025] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Total Healthcare
Address: 3011 W Grand Blvd #1600, Detroit, MI 48202, USA

Vendor Details

Country of origin: India

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Polo 40mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Polo Injection

Benefits of Polo Injection

Side effects of Polo Injection

How to use Polo Injection

How Polo Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Domperidone (Oral Route)

Amiodarone (Oral Route)

Haloperidol (Oral Route)

Haloperidol (Injection Route)

Pimozide (Oral Route)

Frequently asked questions

Can Polo 40mg Injection be used for anxiety?

Is Polo 40mg Injection a sleeping pill?

Can Polo 40mg Injection be taken during pregnancy?

Can I stop taking Polo 40mg Injection if I feel better?

Does smoking or alcohol interfere with the working of Polo 40mg Injection?

Can Polo 40mg Injection be used for anxiety?

Is Polo 40mg Injection a sleeping pill?

How long does it take for Polo 40mg Injection to kick in?

What is the most important information that I should know about Polo 40mg Injection?

Can Polo 40mg Injection be taken during pregnancy?

Can I stop taking Polo 40mg Injection if I am better?

Does smoking or alcohol interfere with working of Polo 40mg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

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