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Pofol Injection

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 01 Feb 2026 | 09:46 PM (IST)
Pofol Injection is a general anesthetic. It is used in major surgical procedures. It allows the procedures to be carried out without pain and distress. This injection is used in a hospital setting only.
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General Information

Contains

Propofol (1% w/v)

Marketer

Meddroid Pharmaceuticals Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Pofol Injection image
Pofol Injection image
Pofol Injection image

Product introduction

Pofol Injection causes loss of consciousness which is reversible. It is administered under the supervision of a doctor or a nurse. U=You should not self-administer this medicine at home.

The most common side effects include headache, vomiting, and nausea. This Pofol Injection is safe to use in pregnancy, breastfeeding mothers, patients of liver and kidney disease. Inform your doctor if you are on any medications or have any known allergy to this medicine before the start of the procedure.

It is not advised to consume alcohol after you have been administered. Driving should not be done as this medicine may cause sleepiness and may impair your ability to think or react. It is also advised not to operate machinery because of these effects.

Uses of Pofol Injection

Benefits of Pofol Injection

General Anaesthesia
Pofol Injection is used as a general anaesthesia to help patients fall asleep quickly and comfortably before surgery or medical procedures. It provides a smooth induction and recovery, ensuring a controlled and safe anaesthetic experience.

Side effects of Pofol Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pofol
  • Nausea
  • Headache
  • Vomiting
  • Local site pain
  • Slow heart rate
  • Decreased blood pressure

How to use Pofol Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Pofol Injection works

Pofol Injection is a general anaesthetic. It works by causing reversible loss of consciousness. This allows surgical procedures to be carried out without pain and distress.

Quick tips

  • Pofol Injection helps induce unconsciousness (sleep) so that surgical operations or other procedures can be performed.
  • It is given to you as an injection by your doctor.
  • After use, you may still feel sleepy for some time. Do not drive or do anything that requires focus until you are sure the effects have subsided.
  • Inform your doctor if you are pregnant, planning to conceive or breastfeeding.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Pofol Injection may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Pofol Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Pofol Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Pofol Injection may cause side effects that could affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Pofol Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, talk to your doctor if you have any underlying kidney disease. Use of Pofol Injection can cause green discoloration of urine.
Liver

Liver

CAUTION
Pofol Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Pofol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Sodium Valproate (Oral Route)

If concurrent use is essential, watch out for symptoms such as dizziness, nausea, headache, pain at the injection site, confusion, muscle twitching, cough, dry mouth, changes in taste or itchiness and consult your doctor if you experience them. They may adjust the doses as per the observations. Sodium Valproate may increase the effect of Propofol.
Moderate

Adrenaline (Injection Route)

Talk to your doctor if you notice any unusual symptoms. Adrenaline may increase the side effects of Propofol.
Moderate

Alfuzosin (Oral Route)

Your doctor may discontinue Alfuzosin 24 hours before the surgery.
Moderate

Baclofen (Injection Route)

Talk to your doctor if you notice any unusual symptoms.Avoid activities like driving, lifting weight.
Moderate

Baclofen (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Avoid activities like driving, lifting weight.

Frequently asked questions

Pofol Injection is an anesthetic medicine used to help you relax, become sleepy, or go to sleep before and during a medical procedure or surgery. It can be used to start general anesthesia or to keep you sedated and comfortable for shorter procedures.<br>
Pofol Injection will only be given by, or under the direct supervision of, a doctor, or other professionals trained in administering anesthesia, such as an anesthesiologist, or a critical care specialist. They will continuously monitor you throughout the entire process.<br>
Pofol Injection works very quickly, usually making you feel its effects within about 40 seconds of the injection starting. This rapid onset is why it is commonly used to begin anesthesia.<br>
The duration of action from a single Pofol Injection dose is quite short, typically lasting for about 10 to 20 minutes. For longer procedures, it will be given as a continuous infusion to maintain the level of sedation or anesthesia needed.<br>
It is very unlikely that you will remember the surgery or procedure. One of the effects of Pofol Injection is amnesia, which means you will not form memories during the time the medicine is active.<br>
No. The Pofol Injection dose is highly individualized. The anesthesiologist will carefully calculate the right amount for you based on your age, weight, medical condition, and the type of procedure you are having.<br>
Some people experience a brief stinging or burning sensation at the IV site when Pofol Injection is first injected. Your anesthesiologist may use techniques to minimize this discomfort, such as giving it through a larger vein or mixing it with a local anesthetic.<br>

Fact Box

Chemical Class

Cumenes

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

General Anesthetics

References

  1. Patel PM, Patel HH, Roth DM. General Anesthetics and Therapeutic Gases. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 536-37.
  2. White PF, Trevor AJ. General Anesthetics. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 436-37.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1161-62.
  4. Propofol. Dublin, Ireland: Aspen; 1986 [revised 06 Nov. 2018]. [Accessed 23 Jan. 2019] (online) Available from:
  5. Propofol. Lake Zurich, Illinois: Fresenius Kabi USA, LLC; 2014. [Accessed 05 Apr. 2019] (online) Available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 05 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Meddroid Pharmaceuticals Pvt Ltd
Address: Ansal Chambers, Bhikaji Cama Place , New Delhi - 110066

Vendor Details

Country of origin: India

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