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Pirozox Injection 1
Pirozox Injection 2
Pirozox Injection 3
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Pirozox Injection

Piroxicam (20mg/ml)
Genuine
Authenticity Assured
Prescription
required
Pirozox Injection is a pain-relieving medicine. It is used in the treatment of moderate to severe pain. It helps to relieve pain and swelling of various conditions related to joints and muscles. It is usually given in cases where oral administration is unsuitable.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
₹37.1 MRP ₹42.1912% off 
(Inclusive of applicable taxes)
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Pirozox Injection
ampoule of 2 ml Injection
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Dolonex IM Injection
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Piroxicam (20mg/ml)
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General Information

Contains

Piroxicam (20mg/ml)

Marketer

JMD Pharma

Storage

Store below 25°C

Preservative

Benzyl Alcohol
The content is shown in English
Pirozox Injection 1
Pirozox Injection 2
Pirozox Injection 3

Product introduction

Pirozox Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.

The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), vomiting, stomach pain, indigestion, diarrhea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

This medicine is not recommended for pregnant or breastfeeding women. Pregnant and breastfeeding mothers must consult with their doctors before using the medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

Uses of Pirozox Injection

Benefits of Pirozox Injection

Pain relief
Pirozox Injection is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis or even after a dental (tooth-related) surgery.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Pirozox Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pirozox
  • Injection site reactions (pain, swelling, redness)
  • Vomiting
  • Stomach pain
  • Nausea
  • Headache
  • Dizziness

How to use Pirozox Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Pirozox Injection works

Pirozox Injection is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).

All substitutes for Pirozox Injection

For information purposes only. Consult a doctor before taking any medicine.

Dolonex IM Injection

by Pfizer Ltd
₹72.58/injection
72% costlier
<h3 class=bodySemiBold>Dolonex IM Injection</h3>

Doromex 20mg Injection

by Paksons Pharmaceuticals Pvt Ltd
₹15/injection
64% cheaper
<h3 class=bodySemiBold>Doromex 20mg Injection</h3>

Quick tips

  • Pirozox Injection helps relieve pain and swelling of various joints and muscles.
  • It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness. 
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Pirozox Injection.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Pirozox Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Pirozox Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Pirozox Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Pirozox Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Pirozox Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Pirozox with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.
Severe

Acenocoumarol (Oral Route)

Do not consume Acenocoumarol with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe

Phenindione (Oral Route)

Do not consume Phenindione with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Warfarin (Oral Route)

Do not consume Warfarin with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

Both Pirozox Injection and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Pirozox Injection.
Both Pirozox Injection and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Pirozox Injection.
Both Pirozox Injection and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Pirozox Injection.
Both Pirozox Injection and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Pirozox Injection. Ketoprofen gel also showed excellent tolerability.
Pirozox Injection is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Both Pirozox Injection and nimesulide are pain killers. However, Pirozox Injection is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Pirozox Injection or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Pirozox Injection.
No. Pirozox Injection and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
No. Pirozox Injection should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
Yes. Methocarbamol can be used with Pirozox Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Yes. Paracetamol can be used with Pirozox Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Yes. Pirozox Injection is a non-steroidal anti-inflammatory drug (NSAID).
Pirozox Injection is a sulphur containing compound. Pirozox Injection can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
No. Pirozox Injection is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
No. Pirozox Injection is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
No. Pirozox Injection is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
No. Pirozox Injection is not a medication to control hypertension. It is important to note that Pirozox Injection decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Pirozox Injection.
No. Pirozox Injection should not be combined with Losartan. It is important to note that Pirozox Injection decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pirozox Injection.
No. Pirozox Injection should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pirozox Injection.
Yes. Pirozox Injection can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Yes, Pirozox Injection can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Yes. Pirozox Injection can be combined with beta-cyclodextrin. Research has shown that combining Pirozox Injection with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Yes. There are alternatives to Pirozox Injection. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
No. Pirozox Injection is not a drug to treat allergy. It is a pain killer.
Pirozox Injection is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
No. Pirozox Injection is not known to cause high. It is a non-narcotic painkiller.
Pirozox Injection is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Pirozox Injection is not approved for the treatment of migraine. Research studies have shown that Pirozox Injection is effective in significantly decreasing the pain associated with migraine without aura.
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Pirozox Injection as the cause of back pain can be different for different person.
Yes. Pirozox Injection can be given for the treatment of acute gout. Research studies have shown Pirozox Injection to be highly effective in the treatment of acute gout.
Pirozox Injection in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Pirozox Injection so taking piroxicam can lead to increased risk of renal failure by many folds.
No. Pirozox Injection should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Yes. Pirozox Injection is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
No. Pirozox Injection should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
No. Pirozox Injection is contraindicated in cases of active peptic ulcer disease. Pirozox Injection is known to cause gastric ulceration and bleeding.
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Yes. Pirozox Injection can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
No. Pirozox Injection should not be used with diuretics. Pirozox Injection reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
No. Pirozox Injection should not be used with lithium. Pirozox Injection leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
No. Pirozox Injection should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

Fact Box

Chemical Class

Benzothiazines

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

Non-Selective COX 1 & 2 Inhibitors (Enolic Acid Derivatives)

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
  2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
  4. Pubchem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
  5. ScienceDirect. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
  6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
  8. Piroxicam [Drug Label]. Metro Manila, Philippines: Pfizer, Inc.; 2022. [Accessed 06 Apr. 2024] (online) Available from:
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Marketer details

Name: JMD Pharma
Address: 602 Chithambaranagar Colony ,Sankarnagarpost,Tirunelveli,Tamilnadu 627357

Vendor Details

Country of origin: India

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