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Phenergan Injection

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 04 Jan 2026 | 12:08 PM (IST)
Phenergan Injection is a systemic antihistamine used to relieve allergic reactions such as itching, sneezing, and rashes. It works by blocking histamine, a substance released during allergies, helping reduce allergy symptoms and discomfort.
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General Information

The content is shown in English
Phenergan Injection image
Phenergan Injection image

Product introduction

Phenergan Injection is given as an injection under the supervision of healthcare professionals. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. You must inform your doctor if symptoms do not improve within 7 days of the treatment.

The most common side effects of this medicine include drowsiness, restlessness, headache, and tiredness. There may be ways of reducing or preventing them. It makes the skin more sensitive towards sunlight. Use sunscreen or wear protective clothing before going out.

Before taking this medicine, let your doctor know if you have glaucoma or have asthma issues, or have high blood pressure. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.

Uses of Phenergan Injection

Benefits of Phenergan Injection

Treatment of Allergic conditions
Phenergan Injection is used to treat many different inflammatory and allergic conditions. It works by lowering your immune system’s response to these conditions and prevents the release of substances in the body that cause inflammation. It helps relieve symptoms such as swelling, pain, itching, and other allergic-type reactions. If you are not sure why you are being given this medicine, ask your doctor.

This medicine is given orally (by mouth). You should always take it as it has been prescribed for you. Do not stop taking it without your doctor’s advice. This can cause unpleasant withdrawal symptoms. Because this medicine weakens your immune system, you should avoid being near people who are ill or have infections.

Side effects of Phenergan Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Phenergan
  • Tiredness

How to use Phenergan Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Phenergan Injection works

Phenergan Injection is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Phenergan Injection works by blocking the action of histamine, thereby relieving these symptoms. It also works directly on several areas of the brain to prevent nausea/vomiting and help you feel more relaxed.

Quick tips

  • Phenergan Injection helps treat nausea, vomiting and allergic conditions.
  • Use caution while driving or doing anything that requires concentration as Phenergan Injection can cause dizziness and sleepiness.
  • Do not drink alcohol while taking this medication as it may cause increased sleepiness.
  • It may make your skin more sensitive to sunlight. Avoid exposing your skin to strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.
  • Do not take it for longer than 7 days. If your symptoms worsen or do not improve after 7 days, talk to your doctor.
  • Stop taking it at least three days before taking an allergy test as it can affect the test results.
  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Phenergan Injection, as it may cause excessive sleepiness or drowsiness.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Phenergan Injection may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Phenergan Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Phenergan Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Phenergan Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Phenergan Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Phenergan Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Phenergan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Promethazine. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Promethazine. Please consult your doctor.
Moderate

Trihexyphenidyl (Injection Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Clozapine (Oral Route)

Watch out for symptoms such as dry mouth, increased heart rate, urination difficulties, constipation, loss of appetite or nausea and consult your doctor if you experience them.
Moderate

Trihexyphenidyl (Oral Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Lorazepam (Oral Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.

Frequently asked questions

Phenergan Injection is antihistaminic drug and not a narcotic/opiate/pain killer. Patient should follow the advice of doctor regarding its use
No, it is available with doctor's prescription only
Phenergan Injection is used for treatment of symptoms of allergies, but not used for hangover, sore throat, stomach flu, cramps, toothache, headache and cough. Patient should follow the advice of doctor regarding its use
Yes, but taking other medicines may alter the effects of Phenergan Injection. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required
Phenergan Injection may cause these side effects which are not serious. However, always consult your doctor if you experience any of these side effects.

Fact Box

Chemical Class

Phenothiazines

Habit Forming

No

Therapeutic Class

RESPIRATORY

Action Class

First-Generation H1 Antihistamines
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User feedback

Once A Day
38%
Once A Month
36%
Once A Week
15%
Twice A Month
6%
Twice A Day
5%
Thrice A Day
1%
Others
56%
Vomiting
38%
Allergic conditions
6%
Excellent
64%
Poor
18%
Average
18%
No Side Effect
67%
Sleepiness
33%
With or without food
57%
With food
43%
Expensive
78%
Not Expensive
11%
Average
11%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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