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Perindosyl 4mg Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Perindosyl 4mg Tablet belongs to a group of medicines known as angiotensin-converting enzyme (ACE) inhibitors. It is used to treat high blood pressure and heart failure and may be prescribed after a heart attack. It also lowers the chances of having a heart attack or stroke.
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General Information

The content is shown in English
Perindosyl 4mg Tablet image
Perindosyl 4mg Tablet image

Product introduction

Perindosyl 4mg Tablet can be prescribed either alone or in combination with other medicines. It can be taken with or without food. This medicine should be taken at the same time each day to get the most benefit. It is important to continue taking it regularly, even if you feel well or if your blood pressure is controlled. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse.


Making some changes in your lifestyle will also help lower your blood pressure. These may involve engaging in regular exercise, maintaining a healthy weight, quitting smoking, limiting alcohol consumption, and following your doctor's recommendations for reducing salt intake.


The most common side effects of Perindosyl 4mg Tablet are cough, dizziness, and back pain. Most of these are temporary and resolve with time. Talk to your doctor if any of these side effects bother you or do not go away.


Before using Perindosyl 4mg Tablet, inform your doctor if you have any kidney or liver conditions. Pregnant or breastfeeding mothers should also consult their doctor before taking it to make sure it is safe for them. While taking this medication, your doctor may regularly monitor your kidney function, blood pressure, and potassium levels.

Uses of Perindosyl Tablet

Benefits of Perindosyl Tablet

Hypertension (high blood pressure)
High blood pressure (hypertension) is a common condition in which the force of the blood against artery walls is too high, increasing the risk of heart disease, stroke, and kidney problems. Perindosyl 4mg Tablet is used to help lower blood pressure and reduce the strain on the heart and blood vessels. Keeping blood pressure in check supports heart health and reduces the risk of related complications.
Heart Failure
Heart failure occurs when the heart can’t pump blood effectively, leading to symptoms like fatigue, breathlessness, and swelling. Perindosyl 4mg Tablet helps improve blood flow and ease the workload on the heart, which can lead to improved breathing, better physical activity tolerance, and a better quality of life.
Prevention of heart attack and stroke
People at risk of heart attack or stroke may benefit from treatments that protect the heart and blood vessels.
Perindosyl 4mg Tablet helps in reducing this risk by improving blood vessel health and controlling blood pressure, which may lower the chances of serious cardiovascular events in the future.

Side effects of Perindosyl Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Perindosyl
  • Cough
  • Dizziness
  • Back pain

How to use Perindosyl Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perindosyl 4mg Tablet may be taken with or without food.

How Perindosyl Tablet works

Perindosyl 4mg Tablet is an angiotensin-converting enzyme (ACE) inhibitor. It works by easing the workload on the heart and widening blood vessels. This allows smoother blood circulation and more efficient heart pumping.

Quick tips

  • Perindosyl 4mg Tablet can make you feel dizzy for the first few days, so rise slowly if you have been sitting or lying down. You can also consider taking it at bedtime to avoid dizziness throughout the day.
  • Let your doctor know about any cough or throat irritation that does not go away.
  • It can lead to elevated potassium levels in the blood. To prevent this, avoid consuming potassium supplements and potassium-rich foods like bananas and broccoli.
  • Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding to make sure it is safe for you.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Perindosyl 4mg Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Perindosyl 4mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Perindosyl 4mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Perindosyl 4mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Perindosyl 4mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Perindosyl 4mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.

Interaction with drugs

Taking Perindosyl with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your kidney function and potassium levels closely.
Severe

Co-trimoxazole (Oral Route)

Do not consume Perindopril erbumine with Co-trimoxazole. If concurrent use is essential, please consult your doctor. They may monitor your potassium levels closely.
Severe

Eplerenone (Oral Route)

If concurrent use is essential, watch out for symptoms such as muscle weakness, fatigue, cramps, nausea, vomiting, tingling, numbness or irregular heartbeat and consult your doctor if you experience them. They may also monitor your potassium levels closely.
Severe

Spironolactone (Oral Route)

Do not consume Perindopril erbumine with Spironolactone in case of kidney disorders. If concurrent use is essential, your doctor may closely monitor your kidney function and adjust or discontinue the medicines accordingly.
Severe

Trimethoprim (Oral Route)

Do not consume Perindopril erbumine with Trimethoprim. If concurrent use is essential, please consult your doctor. They may monitor your potassium levels closely.

Frequently asked questions

Perindosyl 4mg Tablet belongs to a group of medicines known as angiotensin-converting enzyme (ACE) inhibitors. It relaxes and widens the blood vessels, making it easier for the blood to pass through the vessels. As a result of this, the heart does not have to work as hard to push the blood. Since the workload on the heart is reduced, it helps to lower the blood pressure and thus reduces the risk of heart attack and stroke. It is also used for the treatment and prevention of congestive heart failure.
Lifestyle changes play a major role in keeping you healthy if you are taking Perindosyl 4mg Tablet. Avoid taking excess salt in your diet and find ways to reduce or manage stress in your life. Practice yoga or meditation, or take up a hobby. Ensure that you have a sound sleep every night, as this also reduces your stress and hence helps in keeping your blood pressure normal. <br><br>Stop smoking tobacco and drinking alcohol, as this helps lower your blood pressure and helps prevent heart problems. Exercise regularly and eat a balanced diet that includes whole grains, fresh fruits, vegetables, and fat-free products. You should consult your doctor if you need any further help to get the maximum benefit of Perindosyl 4mg Tablet and to keep healthy.
No, continue taking Perindosyl 4mg Tablet even if you feel better and your blood pressure is under control. Stopping Perindosyl 4mg Tablet suddenly may cause your blood pressure to increase, and your chances of a stroke or heart attack may rise. Usually, once you start taking any medicine for controlling blood pressure, you have to continue taking it lifelong unless you cannot tolerate it.
Yes, Perindosyl 4mg Tablet may make you feel dizzy or lightheaded. If Perindosyl 4mg Tablet makes you feel dizzy when you stand up, try getting up very slowly or staying seated until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Don’t drive, do not use tools or machines, and avoid anything requiring concentration while you're feeling dizzy or shaky.
Perindosyl 4mg Tablet should be taken at the same time each day to reduce the chances of a missed dose. Take it in the dose and duration prescribed by the doctor. Your doctor may advise you to take your first dose before bedtime because it can make you dizzy. After the first dose, if you do not feel dizzy, you may take Perindosyl 4mg Tablet at any time of the day. Your dose will depend on the condition you are being treated for, and therefore, it will vary from person to person. If you experience any side effects while taking Perindosyl 4mg Tablet, please consult your doctor.
Perindosyl 4mg Tablet may increase potassium levels in the blood, especially if you have uncontrolled diabetes mellitus, kidney problems, and dehydration. Potassium levels may also increase in patients using potassium salts or medicines that increase potassium levels, or if they are aged more than 70 years of age. If you have any of these conditions and are using Perindosyl 4mg Tablet, you need to be careful and get regular blood tests done to monitor potassium levels.
Perindosyl 4mg Tablet may cause a dry cough as a side effect in some people. This can be persistent and may not be relieved by any medicine. Talk to your doctor if it bothers you or if you have trouble sleeping. Your doctor may suggest ways of managing the cough or may prescribe another medicine. Remember, do not stop taking Perindosyl 4mg Tablet without consulting your doctor, as it may increase your blood pressure and put you at risk of developing a heart attack or stroke. Even if you stop taking Perindosyl 4mg Tablet, the cough may take a few days to a month to resolve completely.
There is no evidence that Perindosyl 4mg Tablet has any effect on fertility in both men and women. However, if you are planning to get pregnant, talk to your doctor first because Perindosyl 4mg Tablet is not recommended in pregnancy.

Fact Box

Chemical Class

Dipeptides

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Angiotensin-Converting Enzyme (ACE) Inhibitors

Related lab tests

References

  1. Pfeffer MA, Opie LH. Inhibitors of the Renin-Angiotensin-Aldosterone System. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 143.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1091-92.
  3. Perindopril erbumin [Prescribing Information]. Cincinnati, Ohio: Patheon Pharmaceuticals, Inc.; 2005. [Accessed 20 Mar. 2019] (online) Available from:
  4. Central Drugs Standard Control Organisation. Perindopril erbumine. [Accessed 05 Aug. 2023] (online) Available from:
  5. Simpson D, Noble S, Goa KL. Perindopril: in congestive heart failure. Drugs. 2002;62(9):1367-77; discussion 1378-9. [Accessed 05 Aug. 2023] (online) Available from:
  6. Perindopril erbumine [Prescribing Information]. Hyderabad, India: Aurobindo Pharma Limited; 2023. [Accessed 01 Mar. 2025] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Elder Pharmaceuticals Ltd
Address: “Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.

Vendor Details

Country of origin: India
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