Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Interaction with drugs
Patient concerns
FAQs

Author Details

Written By

Dr. Subita Alagh

BDS

Reviewed By

Dr. Lalit Kanodia

MBA, MD Pharmacology

Last updated

21 Sep 2025 | 05:34 PM (IST)

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Opisomat 50 Tablet

Prescription Required

Marketer

Neupsy Pharma Pvt.Ltd.

SALT COMPOSITION

Opipramol (50mg)

Storage

Store below 30°C

View available alternative with same salt composition

Product introduction

Opisomat 50 Tablet is a prescription medicine used in the treatment of anxiety disorders. It also helps in restoring the messengers that elevate the mood.

Opisomat 50 Tablet may be taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. If you have missed a dose, take it as soon as you remember and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.

Some common side effects of this medicine include nasal congestion, fatigue, and dryness in the mouth. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it is better to rise slowly if you have been sitting or lying down. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

It is important to inform your doctor if you develop any unusual mood changes, as it may lead to suicidal thoughts. If you have been taking this medicine for a long time, regular monitoring of liver function may be required. Inform your doctor if you have any health conditions associated with the liver, kidneys, or heart. Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking Opisomat 50 Tablet.

Uses of Opisomat Tablet

Anxiety disorder

Benefits of Opisomat Tablet

In Anxiety disorder

Opisomat 50 Tablet is primarily used to treat anxiety disorders. It works by balancing neurotransmitters like serotonin and dopamine, promoting a calming effect and improving mood. Unlike conventional medicine, Opisomat 50 Tablet has mild sedative properties, making it effective for anxiety-related sleep disturbances. It is well-tolerated, with a lower risk of dependency compared to other sedative medicines (like benzodiazepines). This medication helps reduce excessive worry, restlessness, and physical symptoms of anxiety, improving overall quality of life. Regular medical supervision is advised to ensure safe and effective use.

Side effects of Opisomat Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Opisomat

Weight gain
Fatigue
Dryness in mouth
Hypotension (low blood pressure)
Raised itchy skin rash

How to use Opisomat Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Opisomat 50 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Opisomat Tablet works

Opisomat 50 Tablet is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treating depression.

Safety advice

Alcohol

UNSAFE

Opisomat 50 Tablet may cause excessive drowsiness with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Opisomat 50 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Opisomat 50 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Opisomat 50 Tablet may cause side effects which could affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Opisomat 50 Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Opisomat 50 Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Opisomat Tablet?

If you miss a dose of Opisomat 50 Tablet, skip it and continue with your normal schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Do not drive or do anything that requires mental focus until you know how it affects you.
Avoid consuming alcohol when taking this medicine, as it may cause excessive sleepiness or drowsiness.
Your doctor may monitor your blood counts and liver function regularly. Inform your doctor if you develop fever, stomach pain, nausea, or yellowing of your eyes or skin.
Inform your doctor if you are pregnant or breastfeeding, or if you notice changes in your mood or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor first.

Fact Box

Chemical Class

Dibenzazepines Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Tricyclic Antidepressants (TCAs)

Interaction with drugs

Taking Opisomat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Tranylcypromine (Oral Route) Life-threatening

Do not consume Tranylcypromine with Opipramol. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Opipramol. Please consult your doctor. Concomi... More

Moclobemide (Oral Route) Life-threatening

Do not consume Moclobemide with Opipramol. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Opipramol. Please consult your doctor. Concomitant use m... More

Domperidone (Oral Route) Life-threatening

Do not consume Domperidone with Opipramol. Concomitant use may affect heart rhythm and can be fatal.

Tramadol (Injection Route) Severe

Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory impairment, tremors, fever, diarrhea, or agitatio... More

Thioridazine (Oral Route) Severe

If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, weight gain, constipation, muscle stiffness or tremors and consu... More

View all drug interactions

Patient concerns

Mixed anxiety depressive disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.

Mental Depression , Anxiety disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Generalized anxiety disorder problem

Dr. Jyoti Kapoor Madan

Psychiatry

Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it's an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, headaches, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it's better to see a psychiatrist.

Suffering from Anxiety disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it's an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it's better to see a psychiatrist.

PANIC ATTACK ANXIETY DISORDER T

Dr. Jyoti Kapoor Madan

Psychiatry

Am with social anxiety disorder

Dr. Jyoti Kapoor Madan

Psychiatry

It's normal to feel nervous in some social situations. For example, going on a date or giving a presentation may cause that feeling of butterflies in your stomach. But in social anxiety disorder, also called social phobia, everyday interactions cause significant anxiety, fear, self-consciousness and embarrassment because you fear being scrutinized or judged by others. Social anxiety disorder is a chronic mental health condition, but treatment such as psychological counseling, medication and learning coping skills can help you gain confidence and improve your ability to interact with others. Please see a psychiatrist for evaluation and treatment.

Anxiety disorder. always feel t

Dr. Jyoti Kapoor Madan

Psychiatry

What is Opisomat 50 Tablet used for?

Opisomat 50 Tablet is used to treat anxiety disorder. It works by balancing the chemicals that regulate mood.

How long does Opisomat 50 Tablet take to start working?

The exact time Opisomat 50 Tablet takes to show results is not known. However, you may notice improvement in your mood in a few weeks. The full benefits may take longer depending upon the condition and how severe it is.

Can I drink alcohol while taking Opisomat 50 Tablet?

It is best to avoid alcohol while taking Opisomat 50 Tablet. Alcohol can increase drowsiness, make you feel dizzy, and may reduce the effectiveness of the medication.

Can Opisomat 50 Tablet cause weight gain?

Weight gain is not common with Opisomat 50 Tablet, but some people may experience changes in weight. It is a good idea to monitor your weight regularly, such as once a month, and discuss any noticeable changes with your doctor.

When will my doctor adjust my Opisomat 50 Tablet dose?

Your doctor may adjust your dose based on how well you are tolerating the medication, how effective it is for your symptoms, and the levels of Opisomat 50 Tablet in your blood (in some cases).

Who should avoid taking Opisomat 50 Tablet?

Individuals should avoid taking Opisomat 50 Tablet if they have a sudden inability to empty the bladder, sudden confusion or disorientation, a sudden increase in eye pressure causing severe eye pain and vision problems, an enlarged prostate that leaves urine in the bladder after peeing, intestinal blockage due to poor gut muscle movement, and problems with the heart's electrical signals affecting normal heartbeats. Always talk to your doctor to ensure Opisomat 50 Tablet is safe for your specific health conditions.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
Opipramol Dihydrochloride [Product Information]. Mumbai, Maharashtra: Taj Pharmaceutical Ltd. [Accessed 10 Apr. 2025] (online) Available from: