Onset 4mg Injection

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 31 Mar 2026 | 02:31 PM (IST)

Onset 4mg Injection is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused by any surgery, cancer drug therapy, or radiotherapy.

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General Information

Contains

Ondansetron (4mg)

Marketer

Aelida Healthcare

Storage

Store below 30°C

The content is shown in English

Product introduction

Onset 4mg Injection is given under the supervision of a doctor and may be used alone or with other medications. Your doctor will give you the appropriate dose depending on what you are taking it for. You must keep having the injections until your doctor decides it is safe to stop them. After this, your doctor may prescribe tablets instead of the injections.

The most common side effects of taking this medicine include injection site pain, headache, and constipation. These symptoms should disappear when you stop taking the medicine. But if these side effects bother you or do not go away, consult your doctor, who may be able to suggest ways of preventing or reducing them.

Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about other drugs you are using, especially medicines to treat epilepsy, heart problems, cancer, and depression. These may affect or be affected by this medicine. If you are pregnant or breastfeeding, ask for advice from your doctor.

Uses of Onset Injection

Benefits of Onset Injection

Nausea
Onset 4mg Injection helps in relieving nausea, making it easier to go about daily activities without discomfort. Whether caused by travel, certain foods, or other conditions, it provides relief and helps improve overall well-being.

Vomiting
Onset 4mg Injection is useful in managing vomiting, allowing the body to retain essential fluids and nutrients. Reducing the frequency of vomiting helps prevent weakness and dehydration, promoting faster recovery and comfort.

Side effects of Onset Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Onset

Diarrhea
Fatigue
Headache
Injection site pain
Constipation

How to use Onset Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Onset Injection works

Onset 4mg Injection is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

All substitutes for Onset 4mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Onset 4mg Injection is given as an injection into the veins or as a drip under the supervision of a doctor.
Avoid heavy meals and try eating small, nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.
It may cause an application site reaction like redness, swelling, and pain. Consult with your doctor if it bothers you.

Safety advice

Alcohol

SAFE

Consuming alcohol with Onset 4mg Injection does not usually cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Onset 4mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Onset 4mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Onset 4mg Injection does not usually affect your ability to drive.

Kidney

CAUTION

Onset 4mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
However, inform your doctor if you have an underlying kidney disease. Limited information is available in patients taking this medicine for more than one day.

Liver

CAUTION

Onset 4mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Onset with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Hydroxyzine (Oral Route)

Do not consume Hydroxyzine with Ondansetron.

Life-threatening

Voriconazole (Oral Route)

Do not consume Voriconazole with Ondansetron.

Life-threatening

Fluconazole (Oral Route)

Do not consume Fluconazole with Ondansetron.

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Ondansetron.

Life-threatening

Efavirenz (Oral Route)

Do not consume Efavirenz with Ondansetron.

Frequently asked questions

How quickly does Onset 4mg Injection work?

Onset 4mg Injection starts working within half an hour to 2 hours. It dissolves rapidly into the bloodstream and starts showing its effect.

What are the side effects of Onset 4mg Injection?

The most common side effects of Onset 4mg Injection are constipation, diarrhea, fatigue, and headache. However, these are usually not bothersome and resolve on their own after some time. Consult your doctor if these persist or worry you.

Is Onset 4mg Injection a steroid?

No, Onset 4mg Injection is an antiemetic and not a steroid. Onset 4mg Injection is a selective 5-HT3 receptor antagonist. It is prescribed for the prevention and treatment of nausea and vomiting, which are commonly observed after surgery or due to cancer chemotherapy.

Does Onset 4mg Injection work for seasickness?

No, Onset 4mg Injection does not work for seasickness. This is because Onset 4mg Injection has very little effect on the nausea associated with motion sickness.

Fact Box

Chemical Class

Carbazoles

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Serotonin 5-HT3 Receptor Antagonists

References

Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1341-42.
Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 285
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Ondansetron. [Updated 2019 Feb 7]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Ondansetron [Product information]. Eatontown, NJ: WEST-WARD; 2024 [Accessed 02 Apr. 2025] (online) Available from

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Aelida Healthcare
Address: 21, Vita Enclave, Dhulkot, Behind Kingfisher Hotel,Ambala Cantt,Haryana- 34003

Vendor Details

Country of origin: India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Onset 4mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Onset Injection

Benefits of Onset Injection

Side effects of Onset Injection

How to use Onset Injection

How Onset Injection works

All substitutes for Onset 4mg Injection

Isv 4mg Injection

Onsopil 4mg Injection

Zofer 4mg Injection

Ondatriz 4mg Injection

Vonder 4mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Hydroxyzine (Oral Route)

Voriconazole (Oral Route)

Fluconazole (Oral Route)

Domperidone (Oral Route)

Efavirenz (Oral Route)

Frequently asked questions

How quickly does Onset 4mg Injection work?

What are the side effects of Onset 4mg Injection?

Is Onset 4mg Injection a steroid?

Does Onset 4mg Injection work for seasickness?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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