Ondem Injection is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused by any surgery, cancer drug therapy, or radiotherapy.
Ondem Injection is given under the supervision of a doctor and may be used alone or with other medications. Your doctor will give you the appropriate dose depending on what you are taking it for. You must keep having the injections until your doctor decides it is safe to stop them. After this, your doctor may prescribe tablets instead of the injections.
The most common side effects of taking this medicine include injection site pain, headache, and constipation. These symptoms should disappear when you stop taking the medicine. But if these side effects bother you or do not go away, consult your doctor, who may be able to suggest ways of preventing or reducing them.
Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about other drugs you are using, especially medicines to treat epilepsy, heart problems, cancer, and depression. These may affect or be affected by this medicine. If you are pregnant or breastfeeding, ask for advice from your doctor.
Uses of Ondem Injection
Nausea and vomiting due to chemotherapy
Benefits of Ondem Injection
In Nausea and vomiting due to chemotherapy
Ondem Injection blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting associated with cancer treatment such as chemotherapy or radiation therapy in adults as well as children. This medicine helps you recover more comfortably from these treatments. Ondem Injection is also effective at preventing nausea and vomiting after an operation (in adults only). Ondem Injection is given as an injection by a doctor, in the dose that is best for you, depending on the condition you are being treated for. Do not self-administer this medicine to avoid any undesirable side effects.
Side effects of Ondem Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ondem
Injection site pain
Constipation
Diarrhea
Fatigue
Headache
How to use Ondem Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Ondem Injection works
Ondem Injection is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
Safety advice
Alcohol
SAFE
Consuming alcohol with Ondem Injection does not cause any harmful side effects.
Pregnancy
SAFE IF PRESCRIBED
Ondem Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
SAFE IF PRESCRIBED
Ondem Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Ondem Injection does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Ondem Injection is safe to use in patients with kidney disease. No dose adjustment of Ondem Injection is recommended. However, inform your doctor if you have an underlying kidney disease. Limited information is available in patients taking this medicine for more than one day.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Ondem Injection in patients with liver disease. Please consult your doctor.
What if you forget to take Ondem Injection?
If you miss a dose of Ondem Injection, contact your doctor as soon as possible. They will advise you on how to proceed, which may include rescheduling the missed dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Dear Sir/madam Pls advise whats the utility difference in : (1) Ondem-8mg & Ondem-8mg-MD (2) Evion-400 & Evion-600
Dr. Pushkar Mani
Physician
Ondem 8 mg/MD (sustained release) are the same, prescribed in different doses at different intervals, depending on the cause of nausea and vomiting.Evion is basically Vitamin E. 400 and 600 mg are two different doses, thats all.
Lower abdomen pain since 3hrs . History of vomintings since 2hrs 2times
Dr. Pushkar Mani
Physician
Take Ondem 4 mg 1 tab now and another after 4 hourIf vomiting not controlled by tablet than need to give injection of same medicine Ondem 4 mg IMAlso give him ORS sachet
I have 4 month pregnancy & using ondem tab for nausea and vomiting it is safe ? I have also face constipation problem so which medicine is safe to relieve constipation.
Dr. Sonu Balhara Ahlawat
Obstetrics and Gynaecology
Use ondem only when required Also can take isabgul for constipation with hot milk
What were the side-effects while using Ondem Injection?
No Side Effec*
56%
Injection sit*
11%
Injection sit*
11%
Headache
11%
Diarrhea
11%
*No Side Effect, Injection site allergic reaction, Injection site pain
How do you take Ondem Injection?
With or witho*
50%
Empty stomach
33%
With food
17%
*With or without food
Please rate Ondem Injection on price
Average
50%
Not Expensive
28%
Expensive
22%
FAQs
How quickly does Ondem Injection work?
Ondem Injection starts working within half an hour to 2 hours. It dissolves rapidly into the bloodstream and starts showing its effect.
What are the side effects of Ondem Injection?
The most common side effects of Ondem Injection are constipation, diarrhea, fatigue, and headache. However, these are usually not bothersome and resolve on their own after some time. Consult your doctor if these persist or worry you.
Is Ondem Injection a steroid?
No, Ondem Injection is an antiemetic and not a steroid. Ondem Injection is a selective 5-HT3 receptor antagonist. It is prescribed for the prevention and treatment of nausea and vomiting, which are commonly observed after surgery or due to cancer chemotherapy.
Does Ondem Injection work for seasickness?
No, Ondem Injection does not work for seasickness. This is because Ondem Injection has very little effect on the nausea associated with motion sickness.
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References
Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1341-42.
Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 285
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Ondansetron. [Updated 2019 Feb 7]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Ondansetron [Product information]. Eatontown, NJ: WEST-WARD; 2024 [Accessed 02 Apr. 2025] (online) Available from
Country of origin: India Expires on or after: November, 2026
A licensed vendor partner from your nearest location will deliver Ondem Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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