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Onconase 5000IU Injection

Asparaginase (5000IU)

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Cold stored

Stored between 2-8°C

Onconase 5000IU Injection is used in the treatment of some kinds of cancer of white blood cells (leukemia). It may also be used to treat other types of cancer as determined by your doctor. It may be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 14 Apr 2026 | 04:21 PM (IST)

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General Information

Contains

Asparaginase (5000IU)

Marketer

United Biotech Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Onconase 5000IU Injection is given as an injection by the doctor, but try to have it the same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effect of this medicine includes breathlessness, rash, vomiting, angioedema (swelling of deeper layers of skin), and nausea. It might cause increased blood sugar levels, hence regular blood tests are required to monitor your blood sugar levels, response to the therapy, and any side effects. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.

This medicine may lower your body's resistance and increase susceptibility to infections. Infections can sometimes be life-threatening. It is important to use effective contraception to avoid getting pregnant or fathering a child during treatment. Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of Onconase Injection

Blood cancer (Acute lymphocytic leukemia)

Benefits of Onconase Injection

Blood cancer (Acute lymphocytic leukemia)
Onconase 5000IU Injection is used in the treatment of certain blood cancers like acute lymphoblastic leukemia (ALL). It works by starving cancer cells of a vital nutrient, helping slow their growth and improving the effectiveness of cancer treatment.

Side effects of Onconase Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Onconase

Breathlessness
Rash
Vomiting
Angioedema (swelling of deeper layers of skin)
Edema (swelling)
Nausea
Fatigue
Increased liver enzymes
Diarrhea
Decreased blood pressure
Flushing (sense of warmth in the face, ears, neck and trunk)
Low albumin level in blood
Increased glucose level in blood
Hives

How to use Onconase Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Onconase Injection works

Asparaginase belongs to class of medications called antineoplastic agents. Asparaginase is an enzyme that interferes with natural processes necessary for cancer cell growth, thereby killing or stopping the growth of cancer cells.

All substitutes for Onconase 5000IU Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Onconase 5000IU Injection is given as an injection into the veins, muscles or under the skin by the healthcare provider.
It is advisable to drink plenty of fluids and stay hydrated while taking this medication.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, liver function and kidney function during treatment.
It can cause an increase in blood sugar levels. Hence, monitor your blood sugar level regularly.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Onconase 5000IU Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Onconase 5000IU Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Onconase 5000IU Injection during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Onconase 5000IU Injection may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Onconase 5000IU Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Onconase 5000IU Injection in patients with liver disease.
However, regular monitoring of liver function tests is advised while you are taking this medicine.

Interaction with drugs

Taking Onconase with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Imatinib mesylate (Oral Route)

If concurrent use is essential, your doctor may monitor your liver function frequently.

Moderate

Acarbose (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the doses as per the observations.

Moderate

Alogliptin (Oral Route)

Your doctor may monitor your diabetic control closely and adjust the doses as per the observations.

Moderate

Bemiparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.

Moderate

Bevacizumab (Injection Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Frequently asked questions

When should I call my doctor right away?

Get medical help right away if you have signs of allergic reaction such as difficulty breathing, rash, hives, itching, and blisters. Also, let your doctor know if you experience severe headache, chest pain, severe abdominal pain, and swelling in various parts of the body.

Can Onconase 5000IU Injection damage my liver?

Onconase 5000IU Injection may affect the liver and cause serious or even life-threatening damage to the liver. Inform your doctor immediately if you notice severe stomach pain (upper right side), dark urine, clay-colored stools, tiredness, itching, or jaundice (yellowing of the skin or eyes).

I am experiencing nausea and extreme tiredness. Is this due to Onconase 5000IU Injection?

Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.

How to get relief from diarrhea while on treatment with Onconase 5000IU Injection?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.

I have noticed some changes in my skin after taking Onconase 5000IU Injection. What should I do?

Use a moisturizer to get relief from rashes, dry, and itchy skin during the treatment. Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing. However, if you develop yellow discoloration of your skin, inform your doctor immediately as this could be a sign of a liver problem.

Can the use of Onconase 5000IU Injection cause hyperglycemia?

Yes, Onconase 5000IU Injection can cause hyperglycemia or increase blood sugar level. Monitor your sugar level regularly and immediately inform your doctor if you see a spike in your level.

I am noticing swelling and frequent muscle cramps. Should I inform my doctor?

You might experience weakness, muscle cramps and swelling in different parts of your body. This is due to low levels of albumin, an important protein in your body. Consult your doctor who will recommend blood tests to monitor your albumin levels.

Should I avoid any food and drinks while taking Onconase 5000IU Injection?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent you from becoming dehydrated, eating small, simple but nourishing snacks every few hours rather than large meals, and sucking on hard candy or popsicles to prevent nausea and vomiting.

What should I avoid during my treatment with Onconase 5000IU Injection?

During your treatment, it is advisable to avoid caffeine as it can make you feel dehydrated, avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea, avoid alcohol and smoking. It is also advisable to avoid crowds or people with colds, as you may be at risk of infection as well as sun exposure to prevent rashes and dry skin. Do not have immunizations/vaccinations without the consent of your doctor. Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Other Anticancer Agents

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1720-21.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 956.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 88.
Asparaginase. Wedel, Germany: medac GmbH; 2016 [revised Jun. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

User feedback

What are you using Onconase Injection for?

Blood cancer (Acute lymphocytic leukemia)

100%

How much was the improvement?

Excellent

83%

Average

17%

What were the side-effects while using Onconase 5000IU Injection?

Angioedema (swelling of deeper layers of skin)

20%

Rash

20%

Nausea

20%

Breathlessness

20%

Vomiting

20%

How do you take Onconase Injection?

With food

100%

Please rate Onconase 5000IU Injection on price

Expensive

67%

Average

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: United Biotech Pvt Ltd
Address: FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Onconase 5000IU Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Onconase 5000IU Injection

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Onconase Injection

Benefits of Onconase Injection

Side effects of Onconase Injection

How to use Onconase Injection

How Onconase Injection works

All substitutes for Onconase 5000IU Injection

Lagicad 5000IU Injection

L Aspinase 5000IU Injection

Leucoginase 5000IU Injection

L-Aspase 5000IU Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Imatinib mesylate (Oral Route)

Acarbose (Oral Route)

Alogliptin (Oral Route)

Bemiparin (Injection Route)

Bevacizumab (Injection Route)

Frequently asked questions

When should I call my doctor right away?

Can Onconase 5000IU Injection damage my liver?

I am experiencing nausea and extreme tiredness. Is this due to Onconase 5000IU Injection?

How to get relief from diarrhea while on treatment with Onconase 5000IU Injection?

I have noticed some changes in my skin after taking Onconase 5000IU Injection. What should I do?

Can the use of Onconase 5000IU Injection cause hyperglycemia?

I am noticing swelling and frequent muscle cramps. Should I inform my doctor?

Should I avoid any food and drinks while taking Onconase 5000IU Injection?

What should I avoid during my treatment with Onconase 5000IU Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

User feedback

What are you using Onconase Injection for?

How much was the improvement?

What were the side-effects while using Onconase 5000IU Injection?

How do you take Onconase Injection?

Please rate Onconase 5000IU Injection on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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