Nodosis Tablet

Sodium Bicarbonate (500mg)

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Nodosis Tablet is used for the management of metabolic acidosis associated with conditions such as chronic kidney disease (CKD), acute renal failure, diabetic ketoacidosis, severe diarrhea, or shock. It helps delay CKD progression and improve overall survival.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 22 Feb 2026 | 06:32 PM (IST)

₹30.5 MRP ₹33.7510% off

Gurgaon

Available in pack-size of 15 tablets

15 tablets pack-size available

Nodosis Tablet

₹45.1~~₹53.44~~

Available in pack size of 15 tablets

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Nodosis Tablet

strip of 10 tablets

₹30.5

~~₹33.75~~

Different pack-size

Nodosis Tablet

strip of 15 tablets

Sodium Bicarbonate (500mg)

by Steadfast Medishield Pvt Ltd

₹45.1

₹3.01 per tablet

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General Information

Contains

Sodium Bicarbonate (500mg)

Marketer

Steadfast Medishield Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Nodosis Tablet relieves irritation by producing carbon dioxide, which neutralizes the acid present in the stomach. It also increases the pH of blood and urine, thereby correcting acid indigestion, heartburn. Additionally, it helps in the removal of toxic substances from the body in certain types of poisoning.

Nodosis Tablet may be taken with or without food in a dose and duration as advised by the doctor. Excessive intake may cause an electrolyte imbalance, leading to unwanted side effects. Keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back and your condition may worsen.

Common side effects of this medicine include high sodium levels, cerebral edema, alkalosis, and hypokalemia. Let your doctor know if any of these side effects persist or get worse. They may be able to help by adjusting the dosage or by prescribing you an alternate medicine.

It is important to consult a doctor before taking Nodosis Tablet if you are suffering from stomach and kidney disease. Let your doctor also know about all other medications you are taking, as some may affect, or be affected by, this medicine. Pregnant or breastfeeding women should also consult their doctor before taking this medicine.

Uses of Nodosis Tablet

Management of Metabolic acidosis

Benefits of Nodosis Tablet

Management of Metabolic acidosis
Nodosis Tablet helps manage metabolic acidosis, a condition where the body produces too much acid or cannot remove it effectively, leading to a decrease in blood pH. This often occurs in people with chronic kidney disease, diabetic ketoacidosis, or severe dehydration, and can cause fatigue, shortness of breath, and muscle weakness. Nodosis Tablet acts as an alkalinizing agent that neutralizes excess acid and restores the body’s normal pH balance. Correcting this imbalance improves breathing, relieves discomfort related to acid buildup.

Side effects of Nodosis Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nodosis

Increased sodium level in blood
Brain swelling
Alkalosis
Decreased potassium level in blood

How to use Nodosis Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nodosis Tablet may be taken with or without food.

How Nodosis Tablet works

Nodosis Tablet works primarily by providing a source of bicarbonate ions to the body. Nodosis Tablet neutralizes the acidity in the stomach, providing relief from the discomfort of acid reflux or heartburn. It can help temporarily increase the pH of the blood, making it less acidic. This property can be useful in certain medical situations, such as metabolic acidosis, where the body becomes too acidic due to conditions like kidney dysfunction or severe dehydration. Nodosis Tablet may also help in cases where the urine needs to be less acidic, such as when trying to promote the excretion of certain drugs or when managing certain urinary tract conditions.

All substitutes for Nodosis Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Nodosis Tablet at least 1 to 2 hours before or after other medications, as it may affect their absorption.
Avoid taking it with large meals regularly, as excessive use can lead to rebound acidity.
Avoid Nodosis Tablet, if you show signs of appendicitis or inflammed bowel (such as lower abdominal pain, cramping, bloating, nausea, vomiting). Please consult your doctor.
Do not use it as a long-term solution for heartburn or acidity without medical supervision.
Monitor sodium intake if you have high blood pressure, kidney issues, or are on a salt-restricted diet.
Dissolve the Nodosis Tablet completely in water before consuming to reduce the risk of stomach discomfort.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Nodosis Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Nodosis Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Nodosis Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Nodosis Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Nodosis Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Nodosis Tablet in patients with liver disease.

Interaction with drugs

Taking Nodosis with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Ofloxacin (Oral Route)

To take Ofloxacin, ensure a gap of at least 6 hours before or after taking Sodium Bicarbonate. Sodium Bicarbonate may reduce the efficacy of Ofloxacin.

Moderate

Chloroquine (Oral Route)

Ensure a gap of at least 4 hours between taking Chloroquine and Sodium Bicarbonate.

Moderate

Ursodeoxycholic Acid (Oral Route)

Ensure a gap of at least 2 hours between taking Ursodeoxycholic Acid and Sodium Bicarbonate.

Moderate

Azithromycin (Oral Route)

Do not consume Azithromycin with Sodium Bicarbonate. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Sodium Bicarbonate may reduce blood levels of Azithromycin.

Moderate

Sparfloxacin (Oral Route)

To take Sparfloxacin, ensure a gap of at least 6 hours before or after taking Sodium Bicarbonate. Sodium Bicarbonate may reduce the efficacy of Sparfloxacin.

Frequently asked questions

What is the difference between medical-grade sodium bicarbonate (present in Nodosis Tablet) and regular baking soda?

Medical-grade baking soda (present in Nodosis Tablet) includes medical-grade purity and quality control, precise dosing in medical formulations, professional oversight of treatment, and specific medical packaging. However, regular baking soda is mostly used for cooking and baking. It helps the baked product rise and be fluffy. Always use the prescribed form rather than kitchen baking soda.

When should I take Nodosis Tablet?

You can take Nodosis Tablet for heartburn when symptoms occur, while for chronic conditions, you should take it as prescribed by your doctor. It is usually taken between meals, and it is better not to take it within 2 hours of other medications. Follow specific instructions for your condition.

What serious side effects should I watch for?

You should seek medical attention if you experience serious side effects of Nodosis Tablet such as severe stomach pain, swelling of feet or ankles, unusual weakness, slow breathing, and mood changes. These could indicate serious complications.

Who should exercise caution before taking Nodosis Tablet?

Individuals should exercise extra caution if they have high blood pressure, heart problems, kidney disease, liver problems, and are on a salt-restricted diet. They should consult their doctor before use.

Can I take Nodosis Tablet long-term?

You should only use Nodosis Tablet for long-term use under medical supervision. Regular monitoring may be needed in this case. Blood tests might be required, and dosage may need adjustment over time. Always discuss duration with your doctor.

Fact Box

Chemical Class

Organic carbonic acids

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Antacids

References

McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1069.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Sodium Bicarbonate [Product Information]. Ahmedabad, Gujarat: La Renon Healthcare Provate Limited. [Accessed 01 Aug. 2023]. (online) Available from:
Sodium Bicarbonate [Product Label]. Mehatpur, India: Stanford Laboratories Private Limited. [Accessed 06 Aug. 2023]. (online) Available from:
Leeford: Sodium Bicarbonate [Product Information]. [Accessed 27 Oct. 2025]. (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Steadfast Medishield Pvt Ltd
Address: Al Khasra No 322, Nanhera, Anantpur Bhagwaripur, Roorkee, District Handwar -UTTARAKHAND-247 868

Vendor Details

Country of origin: India

Nodosis Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Nodosis Tablet

Benefits of Nodosis Tablet

Side effects of Nodosis Tablet

How to use Nodosis Tablet

How Nodosis Tablet works

All substitutes for Nodosis Tablet

Dosmiford 500mg Tablet

Sobisis 500mg Tablet

Nodosis GST Tablet

Sobisis EC 500 Tablet

Soby 500 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ofloxacin (Oral Route)

Chloroquine (Oral Route)

Ursodeoxycholic Acid (Oral Route)

Azithromycin (Oral Route)

Sparfloxacin (Oral Route)

Frequently asked questions

What is the difference between medical-grade sodium bicarbonate (present in Nodosis Tablet) and regular baking soda?

When should I take Nodosis Tablet?

What serious side effects should I watch for?

Who should exercise caution before taking Nodosis Tablet?

Can I take Nodosis Tablet long-term?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Nodosis Tablet

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

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