Neph-Tolvaptan Tablet
Prescription Required
Product introduction
Neph-Tolvaptan Tablet is a medicine used in the treatment of low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH).
Neph-Tolvaptan Tablet can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so.
Using this medicine may cause few common side effects such as frequent urge to urinate, nocturia (increased urge to urinate during the night), dryness in mouth, increased thirst, nausea, increased blood creatinine, hyperkalemia, and constipation. Let your doctor know if any of these side effects do not go away with time or get worse. Before using this medicine, inform your doctor if you have any problems with your kidneys or liver. While on this medicine, your doctor will closely monitor the sodium levels in your blood. You should also tell your doctor all the other medications you are taking.
Neph-Tolvaptan Tablet can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so.
Using this medicine may cause few common side effects such as frequent urge to urinate, nocturia (increased urge to urinate during the night), dryness in mouth, increased thirst, nausea, increased blood creatinine, hyperkalemia, and constipation. Let your doctor know if any of these side effects do not go away with time or get worse. Before using this medicine, inform your doctor if you have any problems with your kidneys or liver. While on this medicine, your doctor will closely monitor the sodium levels in your blood. You should also tell your doctor all the other medications you are taking.
Uses of Neph-Tolvaptan Tablet
- Treatment of Low levels of sodium in the blood
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Benefits of Neph-Tolvaptan Tablet
In Treatment of Low levels of sodium in the blood
Low levels of sodium may be caused due to multiple reasons such as excess of body fluids, heart disease, and kidney problems. There may be many symptoms such as nausea, headache confusion and the person may even need to get hospitalized. Neph-Tolvaptan Tablet helps to get rid of the excess fluids and retains sodium in the blood. This restores the normal sodium levels in our body and prevents further complications such as memory loss.
Side effects of Neph-Tolvaptan Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Neph-Tolvaptan
- Frequent urge to urinate
- Nocturia (increased urge to urinate during the night)
- Dryness in mouth
- Increased thirst
- Constipation
- Nausea
- Increased creatinine level in blood
- Increased potassium level in blood
How to use Neph-Tolvaptan Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Neph-Tolvaptan Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Neph-Tolvaptan Tablet works
Neph-Tolvaptan Tablet is a vasopressin antagonist. It works by blocking the effect of the hormone vasopressin in the body. This increases urine production, reduces the amount of water in the blood and raises the blood sodium level.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Neph-Tolvaptan Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Neph-Tolvaptan Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Neph-Tolvaptan Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Neph-Tolvaptan Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Neph-Tolvaptan Tablet is safe to use in patients with kidney disease. No dose adjustment of Neph-Tolvaptan Tablet is recommended.
However, the use of Neph-Tolvaptan Tablet is not recommended in patients with severe kidney disease.
However, the use of Neph-Tolvaptan Tablet is not recommended in patients with severe kidney disease.
Liver
CAUTION
Neph-Tolvaptan Tablet should be used with caution in patients with liver disease. Dose adjustment of Neph-Tolvaptan Tablet may be needed. Please consult your doctor.
Use of Neph-Tolvaptan Tablet is not recommended in patients with severe liver disease.
Use of Neph-Tolvaptan Tablet is not recommended in patients with severe liver disease.
What if you forget to take Neph-Tolvaptan Tablet?
If you miss a dose of Neph-Tolvaptan Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Neph-Tolvaptan Tablet
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Quick tips
- Neph-Tolvaptan Tablet treats low sodium levels in the blood.
- It also improves urine flow without causing the body to lose too much sodium as you urinate.
- Take it at the same time everyday. Take it according to the dose and duration prescribed by your doctor.
- To avoid dehydration, it is best to drink something as soon as you feel thirsty, but avoid alcoholic drinks.
- Do not take Neph-Tolvaptan Tablet if you are unable to urinate, if you are unable to tell when you are thirsty, or if you are severely dehydrated.
- You will need to be in a hospital under observation any time you start or restart treatment with Neph-Tolvaptan Tablet.
- Inform your doctor if you notice problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, or mood changes.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Fact Box
Chemical Class
Benzazepine Derivative
Habit Forming
No
Therapeutic Class
UROLOGY
Action Class
Vasopressin Antagonists
Interaction with drugs
Taking Neph-Tolvaptan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Tolvaptan may raise blood levels of Aliskiren.
If concurrent use is essential, please consult your doctor.
Mifepristone may raise blood levels of Tolvaptan.
Do not consume Mifepristone with Tolvaptan. If concurrent use is essential, watch out for symptoms such as weight gain, dizziness
Digoxin may raise blood levels of the active form of Tolvaptan.
watch out for symptoms of Digoxin side effects such as impaired vision, skin rash, nausea, vomiting, diarrhea or di
Tolvaptan may raise blood levels of Fexofenadine.
If concurrent use is essential, please consult your doctor.
Tolvaptan may raise blood levels of Loperamide.
If concurrent use is essential, please consult your doctor.
Patient concerns
FAQs
What is the most important information I need to be aware of while taking Neph-Tolvaptan Tablet?
Neph-Tolvaptan Tablet may cause the level of sodium in your blood to increase too quickly. This quick increase in sodium levels [osmotic demyelination syndrome (ODS)] may cause serious nerve damage, which can further cause coma and even death. The symptoms of ODS could be trouble in speaking, trouble in swallowing or a feeling of food or liquid getting stuck while swallowing, drowsiness, confusion, mood changes, fits, trouble controlling body movement (involuntary movement) and weakness in muscles of the arms and legs.
For how long do I need to take Neph-Tolvaptan Tablet?
Neph-Tolvaptan Tablet is used for correction of sodium levels in blood. Though the dose and duration are prescribed by the doctor, Neph-Tolvaptan Tablet should not be taken for more than 30 days. Once the sodium levels return to normal, it can be stopped after talking to the doctor.
Does Neph-Tolvaptan Tablet affect the sugar levels in blood?
Yes, Neph-Tolvaptan Tablet may increase the blood sugar levels. Therefore, patients with diabetes mellitus need to be extra careful while taking Neph-Tolvaptan Tablet and should keep a check on blood sugar levels regularly.
Who should not take Neph-Tolvaptan Tablet?
You should not take Neph-Tolvaptan Tablet if you have low sodium levels, cannot replace fluids by drinking or if you cannot tell when you are thirsty, dizzy or feeling faint or if your kidneys are not working properly because of excessive loss of fluids. You should also avoid Neph-Tolvaptan Tablet if your body is not able to make urine, you are allergic to Neph-Tolvaptan Tablet or if you are on certain medicines which interfere with the working of Neph-Tolvaptan Tablet.
Can I have grapefruit juice while taking Neph-Tolvaptan Tablet?
No, you should not take grapefruit or grapefruit juice while on Neph-Tolvaptan Tablet. The reason being, grapefruit or grapefruit juice may increase the levels of Neph-Tolvaptan Tablet in your blood and your sodium levels may rise too quickly.
What will happen if I take excess of Neph-Tolvaptan Tablet?
You may need urgent medical attention. Call your doctor or seek emergency service at a nearby hospital. Symptoms of taking too much Tolvaptan may include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, very low blood pressure, passing more urine than normal and fainting.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC,12th ed. editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 714.
- Masters SB. Hypothalamic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 659.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1379-80.
- Tolvaptan. Otsuka Pharmaceutical Co.; 2009 [revised Apr. 2013]. [Accesses 04 Apr. 2019] (online) Available from:
- ScienceDirect. Tolvaptan. [Accessed 04 Apr. 2019] (online) Available from:
- PubChem. Tolvaptan. [Accessed 04 Apr. 2019] (online) Available from:
- Tolvaptan. Wexham, UK: Otsuka Pharmaceuticals (UK) Ltd.; 2015 [revised Feb. 2019]. [Accessed 22 Feb. 2019] (online) Available from:
- Tolvaptan [Product Label]. Mumbai, Maharashtra: Alkem Labs Limited; 2019. [Accessed 07 Aug. 2023]. (online) Available from:
- Rangarajan B, Binoy V, Hingmire SS, Noronha V. Tolvaptan. South Asian J Cancer. 2014 Jul;3(3):182-4. [Accessed 07 Aug. 2023]. (online) Available from:
Marketer details
Name: Zenska Life Sciences Pvt Ltd
Address: SHOP NO 29 FOURTH FLOOR DAWA BAZAR, R.N.T. MARG INDORE Indore MP 452001 IN
Country of origin: India
Expires on or after: March, 2025
A licensed vendor partner from your nearest location will deliver Neph-Tolvaptan Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: March, 2025
A licensed vendor partner from your nearest location will deliver Neph-Tolvaptan Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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