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Tolvaptan is used in the treatment of syndrome of inappropriate antidiuretic hormone secretion (siadh)

How it works

Tolvaptan increases the frequency of urine which, in turn, increases the amount of water released from the body. Removing fluid from the body helps to maintain the level of sodium in the blood.

Common side effects

Headache, Dizziness, Frequent urge to urinate, Nocturia (increased urge to urinate during the night), Dry mouth, Fatigue, Polyuria, Diarrhoea, Increased thirst

Available Medicine

  • ₹430 to ₹825
    Sun Pharmaceutical Industries Ltd
    2 variant(s)
  • ₹396 to ₹756
    MSN Laboratories
    2 variant(s)
  • ₹523 to ₹830
    Lupin Ltd
    2 variant(s)
  • ₹384 to ₹490
    Zydus Cadila
    2 variant(s)
  • ₹479 to ₹959
    Glenmark Pharmaceuticals Ltd
    2 variant(s)
  • ₹396 to ₹756
    MSN Laboratories
    2 variant(s)
  • ₹434 to ₹830
    Centaur Pharmaceuticals Pvt Ltd
    2 variant(s)
  • ₹396 to ₹756
    Macleods Pharmaceuticals Pvt Ltd
    2 variant(s)
  • ₹400 to ₹800
    Alkem Laboratories Ltd
    2 variant(s)

Expert advice

  • Do not eat grapefruit or drink grapefruit juice while taking this medication. If you stop taking tolvaptan for any length of time, do not start taking it again at home. You will need to be in a hospital under observation any time you start or restart treatment with tolvaptan.
  • Consult your doctor immediately if you have any of these signs: problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, mood changes, and seizure (convulsions).
Do not start or continue tolvaptan:
  • if you are allergic to tolvaptan, or to any of the other ingredients of this medicine.
  • if your kidneys do not work (no urine production).
  • if you have a condition which increases the salt in your blood (“hypernatraemia”).
  • if you have a condition which is associated with a very low blood volume.
  • if you do not realise when you are thirsty.
  • if you are pregnant or breastfeeding.
Talk with your doctor before taking tolvaptan:
  • if you cannot drink enough water or if you are fluid restricted.
  • if you have difficulties in urination or have an enlarged prostate.
  • if you suffer from liver disease.
  • if you have diabetes.

Frequently asked questions



Is tolvaptan / samsca a diuretic?
Samscais brand name of tolvaptan and it is a diuretic


Does tolvaptan work in pkd-Polycystic kidney disease?
Yes. Recently it is found that tolvaptan can slow the development and progression of polycystic kidney disease in animal models.

Content on this page was last updated on 22 February, 2017, by Dr. Varun Gupta (MD Pharmacology)