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Natrilix SR Tablet

Indapamide (1.5mg)

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Natrilix SR Tablet is a medicine used to treat high blood pressure. It helps lower blood pressure by reducing excess fluid and relaxing blood vessels, which improves blood flow and supports better heart and kidney health.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 04 Jan 2026 | 12:47 PM (IST)

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General Information

Contains

Indapamide (1.5mg)

Marketer

Servier India Private Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Natrilix SR Tablet makes you lose excess water through urine. It may be used alone or in combination with other medicines. This medicine should be taken only during day time to avoid frequent urination at night. You must take this medicine in the dose and duration as advised by the doctor and never stop it abruptly without consulting the doctor. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse.

It is important to have your blood pressure checked regularly. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake, and weight reduction. You can eat normally while taking this medicine, but try to reduce your salt intake.

Common side effects of this medicine include headache, nausea, dizziness, fatigue, and rashes. Consult your doctor if these side effects bother you. Before taking this medicine, it is better to let your doctor know if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should consult the doctor before taking it. You must inform the doctor about all the other medicines that you are taking apart from this medicine. Regular monitoring of kidney function and electrolytes is important while using this medicine.

Uses of Natrilix Tablet SR

Hypertension (high blood pressure)

Benefits of Natrilix Tablet SR

Hypertension (high blood pressure)
Hypertension is a condition in which blood pressure remains higher than normal, increasing the risk of heart and kidney problems. Natrilix SR Tablet helps lower blood pressure by reducing excess fluid in the body and relaxing blood vessels. This supports better blood pressure control and helps lower the risk of long-term complications.

Side effects of Natrilix Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Natrilix

Rash
Dizziness
Headache
Fatigue
Nausea
Gastrointesinal symptoms
Muscle cramp

How to use Natrilix Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Natrilix SR Tablet may be taken with or without food.

How Natrilix Tablet SR works

Natrilix SR Tablet is a thiazide diuretic. It lowers blood pressure by removing the extra water and certain electrolytes from the body. Over time it also works by relaxing blood vessels and improving blood flow.

All substitutes for Natrilix SR Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

It makes you feel dizzy. Avoid driving and attention requiring activity until you know how it affects you.
Avoid alcohol intake while taking Natrilix SR Tablet as it may increase the dizziness.
It may cause a sudden drop of sodium level in blood. Avoid low sodium diet while you are taking this medication.
Monitor your blood pressure after starting Natrilix SR Tablet, and notify your doctor if it does not go down.
Notify your doctor if you experience dizziness, tiredness, or muscle weakness that does not go away.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Natrilix SR Tablet.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Natrilix SR Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Natrilix SR Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Natrilix SR Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Natrilix SR Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Natrilix SR Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Natrilix with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Lithium carbonate (Oral Route)

Do not consume Lithium carbonate with Indapamide. If concurrent use is essential, your doctor may regularly monitor Lithium carbonate and potassium levels. Watch out for symptoms such as impaired coordination, double vision, dizziness, or confusion, and consult your doctor if you experience them. They may adjust the dose of Lithium carbonate accordingly.

Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.

Moderate

Chloroquine (Oral Route)

Your doctor may monitor your potassium levels closely.

Moderate

Dexamethasone (Oral Route)

If concurrent use is essential, your doctor may monitor your potassium levels along with your overall treatment and adjust the doses as per the observations.

Moderate

Loperamide (Oral Route)

Your doctor may monitor your potassium levels closely.

Frequently asked questions

Can Natrilix SR Tablet cause gout?

Use of Natrilix SR Tablet may impact the patients already diagnosed with gout. Inform your doctor if you have gout before starting Natrilix SR Tablet. The reason being, this medicine can increase the levels of uric acid in blood in these patients. Such patients may experience episodes of gout while on Natrilix SR Tablet. Your doctor may advise regular monitoring of uric acid.

Can Natrilix SR Tablet increase blood sugar?

Natrilix SR Tablet may increase blood sugar levels in diabetic patients. Tell your doctor if you have diabetes as your insulin requirements may change or the dose of your antidiabetic medicines may need modification. Regular monitoring of blood sugar levels is important in diabetes patients taking Natrilix SR Tablet.

Does Natrilix SR Tablet make you sleepy?

No, Natrilix SR Tablet does not make you sleepy. But, if there is excessive loss of salts (hyponatremia, hypokalaemia, or electrolyte imbalance), then it may make you drowsy. Other warning signals of electrolyte imbalance include dry mouth, thirst, weakness, fatigue, lethargy, restlessness, muscle pain or cramps. Electrolyte imbalance may also lead to decreased urine output, increased heart beat and decreased blood pressure. In case you notice any of these symptoms, contact your doctor immediately.

Does Natrilix SR Tablet make you urinate more?

Use of Natrilix SR Tablet tend to increase the frequency of urination in some patients. Natrilix SR Tablet belongs to thiazide class of medicines which are diuretics. These medicines make your body get rid of extra fluid through your kidneys. This also increases the amount of salts (sodium and potassium) and water that you get rid off from the body, helping in decreasing the blood pressure.

How long does it take Natrilix SR Tablet to start working?

The action of Natrilix SR Tablet is gradual. While the initial effects may be seen within a week, it may take several months to experience the full benefits.

Can I take Natrilix SR Tablet for weight loss?

No, Natrilix SR Tablet is not a medicine for weight loss. This medicine is used to lower high blood pressure and to reduce fluid overload in cases of heart failure. In case you experience weight loss while taking Natrilix SR Tablet, it may be due to fluid loss and not due to body fat.

Is it safe to take Natrilix SR Tablet if I am ill?

If you are sick or have fever with sweating or are experiencing vomiting or diarrhea, you should contact your doctor. To cope up with these, you may be advised to stop Natrilix SR Tablet for 2-3 days and continue it after you are well. The reason being, if you are sick, then there can be electrolyte imbalance. Taking Natrilix SR Tablet may enhance this imbalance. Therefore, it should be stopped for 2-3 days.

How much fluid should I drink while taking Natrilix SR Tablet?

It is usually best to drink normal amounts of fluids while taking Natrilix SR Tablet. It is important not to remain thirsty for long periods and to keep yourself hydrated. If you have heart failure or kidney failure, then you need to restrict your fluid intake after discussing with your doctor.

Fact Box

Chemical Class

Benzenesulfonamides

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Thiazide Diuretics

Related lab tests

Kidney Function Test

References

Opie LH, Victor RG, Kaplan NM. Diuretics. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 103.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, Pennsylvania: Wolters Kluwer Health; 2015. pp. 703-704.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Indapamide. [Updated 2019 Feb 7]. [Accessed 19 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Feb. 2019] (online) Available from:
National Health Service. How and when to take indapamide. [Last Revised: 4 Mar 2022]. [Accessed 05 Jul. 2023]. (online) Available from:
Indapamide [Package Insert]. Modipuram, U.P.: Modi-Mundipharma Pvt. Ltd.; 2024 [Accessed 04 Jan. 2026]. (online). Available from:

User feedback

Patients taking Natrilix SR Tablet

Once A Day

100%

What are you using Natrilix Tablet SR for?

Hypertension (high blood pressure)

90%

Edema

Others

How much was the improvement?

Average

42%

Excellent

31%

Poor

27%

What were the side-effects while using Natrilix SR Tablet?

Nausea

30%

Gastrointesinal symptoms

20%

No Side Effect

10%

Fatigue

10%

Constipation

10%

How do you take Natrilix Tablet SR?

With food

83%

With or without food

Empty stomach

Please rate Natrilix SR Tablet on price

Expensive

58%

Average

28%

Not Expensive

14%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Servier India Private Limited
Address: 1703, 17th Floor, Parinee Crescenzo, 'B' Wing, Plot No. 38 & 39 G Block behind MCA, MKC Bandra East, Mumbai 40051

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Natrilix SR Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Natrilix SR Tablet

Cash on delivery

Free Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Natrilix Tablet SR

Benefits of Natrilix Tablet SR

Side effects of Natrilix Tablet SR

How to use Natrilix Tablet SR

How Natrilix Tablet SR works

All substitutes for Natrilix SR Tablet

Diurix 1.5mg Tablet SR

Indipil 1.5mg Tablet SR

Indazee Tablet SR

Elmap 1.5mg Tablet SR

Inditab 1.5mg Tablet SR

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Lithium carbonate (Oral Route)

Tacrolimus (Oral Route)

Chloroquine (Oral Route)

Dexamethasone (Oral Route)

Loperamide (Oral Route)

Frequently asked questions

Can Natrilix SR Tablet cause gout?

Can Natrilix SR Tablet increase blood sugar?

Does Natrilix SR Tablet make you sleepy?

Does Natrilix SR Tablet make you urinate more?

How long does it take Natrilix SR Tablet to start working?

Can I take Natrilix SR Tablet for weight loss?

Is it safe to take Natrilix SR Tablet if I am ill?

How much fluid should I drink while taking Natrilix SR Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Kidney Function Test

References

User feedback

Patients taking Natrilix SR Tablet

What are you using Natrilix Tablet SR for?

How much was the improvement?

What were the side-effects while using Natrilix SR Tablet?

How do you take Natrilix Tablet SR?

Please rate Natrilix SR Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests