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Natclovir 250 Capsule

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Natclovir 250 Capsule is an antiviral medicine used to treat viral infections caused by cytomegalovirus in immunocompromised people who have undergone an organ or bone marrow transplantation. It also reduces the risk of blindness in a serious eye infection caused by CMV, known as CMV retinitis.
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General Information

Contains

Ganciclovir (250mg)

Marketer

Natco Pharma Ltd

Storage

Store below 25°C
The content is shown in English
Natclovir 250 Capsule image
Natclovir 250 Capsule image
Natclovir 250 Capsule image
Natclovir 250 Capsule image

Product introduction

Natclovir 250 Capsule should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. It may be taken with or without food, but it is better to take it at a fixed time. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. You should drink plenty of water while on treatment with this medicine as it helps to prevent dehydration and kidney damage.

Some side effects of this medicine include nausea, vomiting, diarrhea and headache. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.

Uses of Natclovir Capsule

  • Treatment of Cytomegalovirus Infection

Benefits of Natclovir Capsule

Treatment of Cytomegalovirus Infection
Cytomegalovirus infection is a common virus infection which may have no symptoms at all or may have symptoms like fever and fatigue. Severe infection may show symptoms involving the eyes, brain, or other internal organs. This virus is spread through sexual and nonsexual contact with body secretions in people who are immunocompromised or those who have undergone any transplant. Natclovir 250 Capsule helps to prevent multiplication of the infection causing virus and treats the infection. Keep taking it in the dose and duration prescribed by the doctor to get maximum benefit.

Side effects of Natclovir Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Natclovir
  • Vomiting
  • Headache
  • Dizziness
  • Nausea
  • Fatigue
  • Fever
  • Stomach pain
  • Diarrhea
  • Skin rash

How to use Natclovir Capsule

Take this medicine in the dose and duration as advised by your doctor. Natclovir 250 Capsule should be taken with or after food.

How Natclovir Capsule works

Natclovir 250 Capsule is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

All substitutes for Natclovir 250 Capsule

For information purposes only. Consult a doctor before taking any medicine.

Gavir 250 Capsule

by United Biotech Pvt Ltd
₹142.88/capsule
59% costlier
<h3 class=bodySemiBold>Gavir 250 Capsule</h3>

Quick tips

  • Do not skip any doses and finish the full course of treatment even if you feel better.
  • Drink plenty of water while on treatment with this medicine. This helps to prevent dehydration and kidney damage.
  • If you have genital herpes, use barrier methods (condoms) for contraception and avoid sexual contact while the sores are present.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Natclovir 250 Capsule. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Natclovir 250 Capsule during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Natclovir 250 Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Natclovir 250 Capsule may cause side effects that could affect your ability to drive.
You may feel sleepy, dizzy, confused or shaky, or you may lose your balance or have fits while using Natclovir 250 Capsule.
Kidney

Kidney

CAUTION
Natclovir 250 Capsule should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function test and some blood tests may be advised while you are taking this medicine.
Liver

Liver

CAUTION
Natclovir 250 Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Natclovir with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.
Severe

Tenofovir disoproxil fumarate (Oral Route)

Concurrent use may increase the risk of kidney damage.
Moderate

Amphotericin B (Injection Route)

If concurrent use is essential, please consult your doctor. They may monitor your kidney's functioning closely. Amphotericin B may slow down the removal of Ganciclovir from the body.
Moderate

Amphotericin B (Vaginal Route)

If concurrent use is essential, please consult your doctor. They may monitor your kidney's functioning closely. Amphotericin B may slow down the removal of Ganciclovir from the body.
Moderate

Cidofovir (Injection Route)

If concurrent use is essential, please consult your doctor. They may monitor your kidney's functioning closely. Cidofovir may slow down the removal of Ganciclovir from the body.

Frequently asked questions

Natclovir 250 Capsule is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Natclovir 250 Capsule too early, the symptoms may return or worsen.
If you forget a dose of Natclovir 250 Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Natclovir 250 Capsule is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
No, do not stop taking Natclovir 250 Capsule without consulting your doctor even if you are feeling better. Your symptoms may improve before the infection is completely cured. Therefore, for better and complete treatment, it is advised to continue your treatment for the prescribed duration.
Before starting treatment with Natclovir 250 Capsule, tell your doctor if you have any other health problems, like kidney or liver-related issues. This is because certain medical conditions may affect your treatment and you may even need dose modifications. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Consult your doctor if you are planning a baby, if you are pregnant or breastfeeding, before starting treatment with Natclovir 250 Capsule to avoid any harmful effects on the baby.

Fact Box

Chemical Class

Hypoxanthines

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Action Class

Antiviral Agents (Non-HIV)

References

  1. Acosta EP, Flexner C. Antiviral Agents (Nonretroviral). In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1603-605.
  2. Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 851-52.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 613-14.
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India

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