Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Interaction with drugs
Patient concerns
User feedback
FAQs

Author Details

Written By

Dr. Swati Mishra

BDS

Reviewed By

Dr. Lalit Kanodia

MBA, MD Pharmacology

Last updated

24 Aug 2025 | 11:45 AM (IST)

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Minirin Nasal Spray

Prescription Required

Marketer

Ferring Pharmaceuticals

SALT COMPOSITION

Desmopressin (0.1mg/ml)

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

Click here to view all substitutes

Product introduction

Minirin Nasal Spray is used in the treatment of diabetes insipidus and bed-wetting. This medicine helps decrease the urge to urinate and help resume more normal life-style. It is generally used in patients who cannot take the oral form of medicine.

Minirin Nasal Spray should be used as you have been advised by your doctor. Normally you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other and then sniff hard to make sure it reaches deep into the nose. Then repeat for the other nostril.

The most common side effects of this medicine include nasal discomfort, nasopharyngitis, nasal congestion, sneezing, headache, nausea, and cough. These are usually mild but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.

It is generally a safe medicine but, before taking it, talk to your doctor about any health problems you have such as heart problems or high blood pressure (hypertension) or overactive thyroid gland or glaucoma or prostate enlargement. Let your doctor know about any other medicines you are taking to make sure you are safe. Ask your doctor for advice before using this medicine if you are pregnant or breastfeeding.

Uses of Minirin Nasal Spray

Bleeding esophageal varices
Diabetes insipidus
Bed-wetting

Side effects of Minirin Nasal Spray

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Minirin

Nasal discomfort
Nasopharyngitis (inflammation of the throat and nasal passages)
Nasal congestion (stuffy nose)
Sneezing
Nosebleeds
Dizziness
Headache
Nausea
Cough

How to use Minirin Nasal Spray

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.

How Minirin Nasal Spray works

Minirin Nasal Spray is a synthetic form of vasopressin (natural hormone that balances water). It is rapidly absorbed into the bloodstream through the inner surface of the nose. Once absorbed, it works by causing reabsorption of water from the kidneys which controls excessive thirst and urination in diabetes insipidus. It also helps decrease night-time urine production in multiple sclerosis.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Minirin Nasal Spray during pregnancy is not available. Please consult your doctor.

Breast feeding

CAUTION

Minirin Nasal Spray should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

What if you forget to take Minirin Nasal Spray?

If you miss a dose of Minirin Nasal Spray, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not use extra to make up for a missed dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Minirin Nasal Spray

₹666/Nasal Spray

Dpressin Nasal Spray

United Biotech Pvt Ltd

₹1644/nasal spray

132% costlier

Quick tips

The right way to use the nasal spray:
- Shake the bottle before using the medicine.
- Clean your nose thoroughly before using the medicine.
- Insert the bottle tip into one nostril and close the other nostril.
- Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose.
- Breathe out gently through your mouth and repeat the same process for the other nostril.
Limit the amount of fluids you drink with this medication.
Do not share the bottle with anyone else so that you do not spread germs.
Use the Minirin Nasal Spray within 3 weeks of opening it and discard the rest.

Fact Box

Chemical Class

Vasopressin analogues

Habit Forming

Therapeutic Class

HORMONES

Action Class

Vasopressin Analogues

Interaction with drugs

Taking Minirin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Aceclofenac (Oral Route) Moderate

Caution is advised when taking Desmopressin with Aceclofenac. Your doctor may monitor your sodium levels closely. Concurrent use may cause increased water retention and/or low blo... More

Aceclofenac (Injection Route) Moderate

Caution is advised when taking Desmopressin with Aceclofenac. Your doctor may monitor your sodium levels closely. Concurrent use may cause increased water retention and/or low blo... More

Aceclofenac (Oral Route) Moderate

Caution is advised when taking Desmopressin with Aceclofenac. Your doctor may monitor your sodium levels closely. Concurrent use may cause increased water retention and/or low blo... More

Amitriptyline (Oral Route) Moderate

Caution is advised when taking Desmopressin with Amitriptyline. Your doctor may monitor your sodium levels closely. Concurrent use may cause increased water retention and/or low b... More

Tolvaptan (Oral Route) Moderate

Your doctor may monitor your treatment and adjust the doses as per the observations. Concurrent use may increase the risk of bleeding.

View all drug interactions

Patient concerns

I have diabities insipidus. I have use regularly minirin nasal spray for last 6 -7 years. Any other alternate of these spray or any other treatment. This spray is also costly. Pl help me. 9XXXXXX

Dr. Sanjay Bhatt

Physician

Tablet form us also available.

Bed wetting every night help pl Any medicine for bed wetting

Dr. Gopal Bansilal Samdani

Paediatrics

There are many underlying causes of your symptoms. Specific treatment can not be given unless we establish exact underlying cause. Please consult Pediatrician. will take detail history and will examine your child in detail. At time may ask you relevant investigations if necessary. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment.

Bed wetting in night since 1.5year My baby every night bed wetting pl explain. Reasons.

Dr. Gopal Bansilal Samdani

Paediatrics

Generally, bed-wetting before age 7 isn't a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child's doctor if: Your child still wets the bed after age 7 Your child starts to wet the bed after a few months or more of being dry at night Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring

Children Bed Wetting Treatment

Dr. Gopal Bansilal Samdani

Paediatrics

Bed wetting Generally, bed-wetting before age 7 isn't a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child's doctor if: Your child still wets the bed after age 7 Your child starts to wet the bed after a few months or more of being dry at night Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring

Bed wetting during sleep at night

Dr. Gopal Bansilal Samdani

Paediatrics

Generally, bed-wetting before age 7 isn't a concern. At this age, your child may still be developing nighttime bladder control. Most children outgrow bed-wetting on their own ? but some need a little help. In other cases, bed-wetting may be a sign of an underlying condition that needs medical attention. Consult your child's doctor if: ?Your child still wets the bed after age 7 ?Your child starts to wet the bed after a few months or more of being dry at night ?Bed-wetting is accompanied by painful urination, unusual thirst, pink or red urine, hard stools, or snoring

User feedback

Patients taking Minirin Nasal Spray

Thrice A Day

86%

Twice A Day

14%

What are you using Minirin Nasal Spray for?

Diabetes insi*

53%

Bed-wetting

28%

Others

19%

*Diabetes insipidus

How much was the improvement?

Excellent

61%

Average

25%

Poor

14%

What were the side-effects while using Minirin Nasal Spray?

No Side Effec*

76%

Headache

Flushing (sen*

Sneezing

Abdominal cra*

*No Side Effect, Flushing (sense of warmth in the face, ears, neck and trunk), Abdominal cramp

How do you take Minirin Nasal Spray?

With or witho*

68%

With food

28%

Empty stomach

*With or without food

Please rate Minirin Nasal Spray on price

Expensive

64%

Average

22%

Not Expensive

14%

FAQs

What precautions do I need to take while on Minirin Nasal Spray?

Follow all the instructions given by your doctor strictly. Restrict water intake after taking Minirin Nasal Spray as drinking too much water can lead to fluid overload, which is a serious side effect. Try not to swallow water while swimming.

How long do I need to give Minirin Nasal Spray to my child for bedwetting?

Minirin Nasal Spray is usually prescribed for 3 months for bedwetting. After 3 months, your doctor will stop the medicine for a week to assess whether your child still needs Minirin Nasal Spray or not.

Does Minirin Nasal Spray cure bed wetting?

No, Minirin Nasal Spray does not cure bedwetting, but it helps control bedwetting. It works by replacing a hormone (vasopressin) that is normally produced in the body to help balance the amount of water and salt.

Does Minirin Nasal Spray make you gain weight?

No, Minirin Nasal Spray itself does not cause weight gain. Minirin Nasal Spray may cause fluid overload which may in turn cause weight gain. Fluid overload is a serious side effect and you should immediately contact your doctor if you experience headache, nausea, vomiting, restlessness, tiredness, loss of appetite, sleepiness, confusion and muscle cramps.

Is Minirin Nasal Spray a diuretic?

No, Minirin Nasal Spray is not a diuretic. It is a hormone which helps lower urine output in patients with diabetes insipidus and helps control bedwetting in children. It works by reducing the amount of urine produced by the kidneys, thereby reducing the frequency of urination.

Show less

Related lab tests

Anti Diuretic Hormone

Osmolality - Serum

Osmolality - Urine

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC,12th ed. editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 712-14.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 375.
Medlineplus. Desmopressin Nasal. [Accessed 04 Apr. 2019] (online) Available from:
Desmopressin. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2007. [Accessed 04 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 3 Apr. 2019] (online) Available from:
Desmopressin Acetate [Prescribing Information]. Mumbai, Maharashtra: Sun Pharmaceutical Industries Ltd.; 2012. [Accessed 17 Jun. 2023] (online) Available from: