Metsafe 500mg Tablet SR

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Composition for Metsafe 500mg Tablet SR

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Primarily used for

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₹1.5/Tablet SR
10 tablet sr in 1 strip
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Medicine Overview of Metsafe Tablet SR

uses

Uses of Metsafe Tablet SR

Metsafe 500mg Tablet SR is used in the treatment of type 2 diabetes.
uses

Side effects of Metsafe Tablet SR

Common

Nausea, Vomiting, Altered taste, Diarrhoea, Abdominal pain, Loss of appetite.

uses

How to use Metsafe Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Metsafe 500mg Tablet SR with food.

How Metsafe Tablet SR works

Metsafe 500mg tablet sr is an anti-diabetic medication. It lowers the production and absorption of glucose in your body and allows better use of existing insulin.

In Depth Information on Metsafe Tablet SR

Expert advice for Metsafe Tablet SR

  • Well tolerated antidiabetic medicine with a low risk of weight gain and hypoglycemia.
  • Can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Get blood sugar levels checked at regular intervals and always keep a source of sugar with you for quick relief.
  • Take it with food to avoid stomach upset like nausea, gas, stomach pain and diarrhea. However, this usually gets relieved on its own. Contact your doctor if it persists for a long time.
  • Inform your doctor if you have a kidney disease. Your dose may need to be adjusted.
  • Can cause Vitamin B12 deficiency and symptoms of anemia like tiredness, pale skin, shortness of breath or headache. Inform your doctor as you may need supplements.
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Warnings
Special precautions for Metsafe 500mg Tablet SR
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Alcohol
CAUTION
Taking metformin with alcohol can cause lactic acidosis and
you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
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Pregnancy
PROBABLY SAFE
Metsafe 500mg Tablet SR is probably safe to use during pregnancy.

Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
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Lactation
Metsafe 500mg Tablet SR is probably safe to use during lacta
tion. Limited human data suggests that the drug does not represent a significant risk to the baby.
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Driving
Your ability to drive may be affected if your blood sugar is
low or high. If this happens, do not drive.
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Kidney
CAUTION
Metsafe 500mg Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Metsafe 500mg Tablet SR may be needed. Please consult your doctor.

Use of Metsafe 500mg Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
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Liver
CAUTION
Metsafe 500mg Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Metsafe 500mg Tablet SR may be needed. Please consult your doctor.

Metsafe 500mg Tablet SR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
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Severely interacts with other drugs like
Ketasma 1mg Tablet, Peptiran 75mg/5ml Syrup, Decamycin 4mg Injection, Manoprolol 40mg Tablet

Missed Dosageuses

If you miss a dose of Metformin, skip it and continue with your normal schedule. Do not double the dose.

Patient Concerns

Frequently asked questions for Metsafe 500mg Tablet SR

Frequently asked questions for Metformin

Metsafe is commonly used off-label for the treatment of polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body which improves menstrual cycles and pregnancy rates and outcomes in these patients. It also improves the insulin sensitivity and prevents the development of gestational diabetes and type 2 diabetes mellitus commonly seen in these patients.
Metsafe helps in weight loss by decreasing hunger (appetite) and hence food intake. It makes the insulin already available in your body to work more effectively. This leads to decrease glucose production, increase glucose use and decreased fat deposits which further helps to lower body weight. However, it is not yet approved for weight loss, this is an off-label use.
Metsafe is commonly used off-label for the treatment of infertility associated with polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body and improves menstrual regularity and pregnancy rates and outcomes. This beneficial effect is thought to be due to improvement in insulin resistance by Metsafe.
Metsafe can lower blood sugar level (hypoglycemia). It happens more often if you delay or miss your food, do more than your routine exercise, drink alcohol or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important and be cautious of symptoms of hypoglycemia and always keep glucose tablets, honey or fruit juice with you.
Metsafe is generally a safe and well-tolerated drug even on long-term use. However, its long-term use can cause vitamin B12 deficiency leading to anemia and peripheral neuropathy (nerve damage). so, it should be taken only at prescribed doses for the duration as advised by the doctor.
No, Metsafe is not a sulfonylurea. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
No, Metsafe is not a steroid. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modifications in diet and exercise.
Metsafe commonly causes stomach upset like bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea. To avoid these side effects, it is advised to be taken after meals, preferably started at a low dose and then increased slowly over weeks, or by using slow-release tablets.
Metsafe is seen to be beneficial in the treatment of non-alcoholic fatty liver disease (NAFLD). One of the underlying cause of NAFLD is insulin resistance. Metsafe improves insulin resistance and liver enzymes in these patients. It is not seen to benefit patients of alcoholic fatty liver disease and is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis.
Q. What is the benefit of combining Metsafe with coenzyme q10?
Coenzyme Q10 is an antioxidant that helps in energy production and is found in heart, liver, kidney, and pancreas (which produces insulin). It can repair the damage caused to these organs by free radicals. Low levels of CoQ10 are seen in patients with diabetes. So, some researchers suggest it be given from outside. It can be taken with Metsafe as no drug-drug interactions or harmful effects have been seen between the two.
Yes, Metsafe does improve menstrual cycle (periods) regularity in women with polycystic ovarian syndrome (PCOS). It is associated with insulin resistance, decreased ovulation, and high androgen levels which cause menstrual irregularities like delayed periods and scanty bleeding. Metsafe helps in regularizing menstrual cycles by improving insulin sensitivity, ovulation rate, and decreasing androgen levels.
Q. Can I take Metsafe with atorvastatin?
Yes, Metsafe can be taken with atorvastatin. There are no reported harmful effects when they are used together. Rather some studies suggest beneficial effects in diabetics as they may prevent a very high increase in blood glucose after food, decrease some inflammation markers and protect the patients from liver injury.
Q. Can I take Metsafe with phentermine?
Metsafe can be taken with phentermine. These are sometimes given together in obese patients who are also diabetic and are taking Metsafe along with exercise and diet modification. Phentermine decreases food intake by its action in the brain. However, phentermine can decrease the effect of Metsafe leading to very high blood glucose levels. So, a dose adjustment of Metsafe may be needed.
Q. Can I take Metsafe with levothyroxine?
Metsafe can be taken with levothyroxine but the dose of Metsafe may need to be adjusted. Levothyroxine can decrease the effect of Metsafe leading to very high blood glucose levels. These are used together in patients with coexisting thyroid disease and diabetes mellitus or polycystic ovarian syndrome (PCOS).
Q. Can I take Metsafe with prednisolone?
Metsafe can be taken with prednisolone but the dose of Metsafe may need to be adjusted. Prednisolone can decrease the effect of Metsafe leading to very high blood glucose levels. Continuous use of steroids like prednisolone can also cause diabetes known as glucocorticoid-induced diabetes and use of Metsafe is recommended in these patients.
Q. Can I take Metsafe with metoprolol?
Metsafe can be taken with metoprolol. There are no reported drug interactions or harmful effects in humans when they are used together. However, some animal studies suggest that metoprolol can decrease the blood levels of Metsafe and on long-term use can increase lactic acid and uric acid levels.
Metsafe is not indicated for clearing acne due to just any condition. It only helps in clearing acne in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, abdominal obesity, and irregular menstruation.
No, hair loss has not been reported with Metsafe. It only helps in clearing facial hair (hirsutism) in women with polycystic ovarian syndrome (PCOS) along with other problems like acne, abdominal obesity, and irregular menstruation.
No, weight gain has not been reported with Metsafe. Rather it helps in decreasing weight especially abdominal fat patients of type 2 diabetes mellitus and in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, acne, and irregular menstruation.
Metsafe is not known to cause constipation. Some common side effects associated with the use of Metsafe includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
Metsafe is a safe and well-tolerated drug even on long-term use when taken strictly as advised by the doctor. However, there are some very common side effects like nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite you may experience even at therapeutic doses.
Metsafe is not known to increase blood pressure. Some common side effects associated with the use of Metsafe includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
No, Metsafe is not an insulin. Metsafe is an oral drug used in type 2 diabetes mellitus and lowers blood glucose levels by decreasing its production and increasing absorption and making the already available insulin in your body to work better. Insulin is a normally produced hormone in the body, used in the injectable form in the treatment of both type 1 and 2 diabetes mellitus and it works by absorbing and storing glucose from the blood.
No, Metsafe is not a banned drug. It is a prescription medicine and is available when prescribed by registered medical practitioner.
No, Metsafe is not a birth control pill. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
No, Metsafe is not a statin. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Can I take Metsafe with saxagliptin?
Both Metsafe and saxagliptin are anti diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metsafe is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Metsafe is not known to cause blurred vision. Change in vision in a patient with diabetes could be due to multiple reasons. It could be a temporary problem either due to high blood sugar levels which cause your lens inside your eye to swell and change your vision. If the blurred vision continues for a long time, consult a doctor.
Lactic acidosis is a rare, but serious complication associated with the use of Metsafe. Patient has high blood lactic acid levels and may present with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is especially seen in old age patients, those with kidney, liver or heart disease, or who take large amounts of alcohol. If you have these symptoms, stop taking Metsafe and consult your doctor.
Metsafe is not known to cause any liver pain or damage. Rather, it is seen to be useful in patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, it is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis which is a serious complication associated with the use of Metsafe.
No, Metsafe does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metsafe include anxiety and depression.
Usually, Metsafe is not associated with back pain. However, it can be a presentation of stomach upset, a common side effect caused by Metsafe which includes bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea, or it could be a symptom of lactic acidosis, a rare and a serious complication of Metsafe.
Q. Can long-term use of Metsafe cause vitamin b12 deficiency?
Yes, Metsafe causes vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Yes, Metsafe is seen to be useful in the management of metabolic syndrome, a collection of risk factors that include high blood pressure, high blood sugar levels, abnormal blood cholesterol levels and excess fat around the waist. Metsafe is an insulin sensitizer and it improves the action of insulin and normalises blood sugar levels and reduces body weight.
Q. How beneficial is it to take Metsafe with glimepiride?
Both Metsafe and glimepiride are anti diabetic drugs and can be used together. They work by different mechanisms and can control the blood sugar levels in a much better way when used together as compared to either drug taken alone. However, glimepiride can cause very low blood glucose levels, so a regular monitoring of blood glucose is very important.
Q. Is it safe to take Metsafe with cetirizine?
Yes, Metsafe can be taken with cetirizine. There are no reported drug interactions or harmful effects when they are used together.
Q. Can I take Metsafe and ranitidine together?
Metsafe can be taken with ranitidine. However, if you are taking them together, you need to monitor blood glucose levels regularly as ranitidine can decrease the removal of Metsafe from the body and increase its blood levels. This can cause very low blood sugar levels and other side effects as well and the dose of Metsafe may need adjustment.
Q. How beneficial is it to take Metsafe with linagliptin?
Both Metsafe and linagliptin are anti-diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metsafe is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Q. Does Metsafe inhibit hepatitis B virus protein?
Yes, some research studies have shown that Metsafe can decrease the multiplication and growth of hepatitis B virus when given along with other antiviral drugs. However, this is indication is still under research and not yet approved.
Metsafe should be temporarily discontinued before chest or any X-ray that requires injection of a contrast medium or dye. These dyes can decrease kidney function and Metsafe along with these dyes can cause a serious side effect like lactic acidosis. So you may need to stop taking Metsafe. However, do not stop taking any medicine without talking to your doctor.
Metsafe can cause sleepiness which could be an early symptom of lactic acidosis along with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is a serious condition caused by Metsafe seen in old age patients, those with kidney, liver or heart disease, or those who take large amounts of alcohol. If you have these symptoms, stop taking Metsafe and consult your doctor.
Use of Metsafe is not associated with joint pain. However, diabetes itself decreases blood circulation to the joints and even damages them leading to joint pain. Use of anti-diabetic drugs like sitagliptin or saxagliptin is also associated with joint pain. Early symptoms of lactic acidosis like muscle pain and cramps with weakness and tiredness can be mistaken for joint pain.
Metsafe may be of help in the treatment and prevention of weight gain caused by antipsychotics along with lifestyle modifications like a change in diet and regular exercise. Weight gain is an important reason for discontinuation of these medicines. Metsafe improves insulin sensitivity and prevents weight gain, both of these factors are affected by the use of antipsychotics.
Q. How is gliclazide different from Metsafe?
Both Metsafe and gliclazide are antidiabetic drugs but work in different ways. Metsafe works by decreasing glucose production from liver and decreasing glucose absorption from the gut and increasing insulin sensitivity. Gliclazide works by increasing insulin release from the pancreas. Both control blood sugar levels effectively but Metsafe causes more of stomach upset, like nausea, vomiting, diarrhea and bloating while gliclazide causes low blood sugar levels and weight gain.
Metsafe has shown promising results in some animal research studies in the treatment of fragile X syndrome. It may help in improving mental and behavioral disorders (autism) and control obesity and risk of developing diabetes in these patients. But these results are very preliminary and it is still not approved for the treatment of fragile X syndrome.
Q. What is the difference between liraglutide and Metsafe?
Metsafe and liraglutide are antidiabetic drugs and both control blood sugar levels effectively. Metsafe is taken by oral route and it decreases glucose production from liver and glucose absorption from the gut and increases insulin sensitivity. While liraglutide is an injectable and it increases insulin release from the pancreas. Both cause stomach upset, like nausea, vomiting, diarrhea and bloating while liraglutide also increases the risk of pancreatitis.
No, Metsafe does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metsafe include anxiety and depression.
Yes, sweating is one of the known side effects of Metsafe. The exact cause of this is not known. Some researchers suggest it to be due to low blood sugar levels especially at night which can cause night sweats as well. Monitor your blood sugar levels regularly and talk to your doctor as your dose of Metsafe may need to be adjusted.
Q. Can I take Metsafe with clomiphene citrate?
Metsafe can be taken with clomiphene citrate. They are advised together in patients with infertility along with polycystic ovarian syndrome (PCOS). Clinical studies have shown an improvement in ovulation and pregnancy rates in these patients as compared to use of clomiphene citrate alone or if the patients are resistant to the effects of clomiphene citrate. However, this is still under research.
Metsafe is seen to be useful in the treatment and prevention of cancers especially breast cancer in research studies. As high insulin levels are known to increase the risk of cancer, Metsafe decreases cancer cell growth by decreasing insulin and blood glucose levels. However, its use in treating breast cancer is not yet approved.
No, Metsafe is not associated with an increased risk of Helicobacter pylori infection. Diabetes itself increases the risk of H.pylori infection which increases the chances of stomach upset like nausea, vomiting, diarrhea, and bloating by Metsafe.
Metsafe may decrease the levels of vitamin B12 on long term use which may rarely cause a type of anemia in which blood cells are larger than normal (megaloblastic anemia). You may need to take foods rich in vitamin B12 like eggs, dairy products, and meat or a supplement from outside.
Metsafe is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. Metsafe makes the insulin already available in your body to work more effectively, decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Metsafe.
Q. Can I take Metsafe with teneligliptin?
Yes, Metsafe can be taken with teneligliptin. It is a good add-on treatment if the blood sugars are very high even after taking Metsafe. The risk of low blood sugar levels (hypoglycemia) is also very low with both the medicines. However, consult your doctor before taking them together as a dose adjustment may be needed.
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