Metha 25mg Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Metha 25mg Tablet used in the treatment of nausea and vomiting related to certain conditions like before/after surgery or motion sickness. It may also be used to treat allergic conditions such as rash, itching, and runny nose.

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General Information

Contains

Promethazine (25mg)

Marketer

General Pharmaceuticals Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Metha 25mg Tablet should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depend on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. If you miss a dose, take it as soon as you remember it. However, you should never take a double dose. Inform your doctor if your symptoms do not improve within 7 days of treatment.

The most common side effects of this medicine include dry mouth, blur vision, headache, and feeling dizzy. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes skin more sensitive to sunlight. Use a sunscreen or wear protective clothing before going out.

Before taking this medicine, let your doctor know if you have glaucoma or have asthma issues, or have high blood pressure. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.

Uses of Metha Tablet

Benefits of Metha Tablet

Treatment of Allergic conditions
Metha 25mg Tablet is used to treat many different inflammatory and allergic conditions. It works by lowering your immune system’s response to these conditions and prevents the release of substances in the body that cause inflammation. It helps relieve symptoms such as swelling, pain, itching, and other allergic-type reactions. If you are not sure why you are being given this medicine, ask your doctor.

This medicine is given orally (by mouth). You should always take it as it has been prescribed for you. Do not stop taking it without your doctor’s advice. This can cause unpleasant withdrawal symptoms. Because this medicine weakens your immune system, you should avoid being near people who are ill or have infections.

Treatment of Motion sickness
Motion sickness is a condition caused due to motion during travel. You may experience spinning sensation (vertigo), nausea or vomiting as a result of this condition. Metha 25mg Tablet helps treat these symptoms effectively. Take it as prescribed by the doctor to get maximum benefit.

Treatment of Nausea
Metha 25mg Tablet blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting that may be caused due to some medicines or any other medical treatment. This medicine helps you recover more comfortably. The dose will depend on what you are being treated for but always take this medicine as it is prescribed.

How to use Metha Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metha 25mg Tablet may be taken with or without food.

How Metha Tablet works

Metha 25mg Tablet is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Metha 25mg Tablet works by blocking the action of histamine, thereby relieving these symptoms. It also works directly on several areas of the brain to prevent nausea/vomiting and help you feel more relaxed.

Quick tips

Metha 25mg Tablet helps treat nausea, vomiting and allergic conditions
Use caution while driving or doing anything that requires concentration as Metha 25mg Tablet can cause dizziness and sleepiness.
Do not drink alcohol while taking this medication as it may cause increased sleepiness.
It may make your skin more sensitive to sunlight. Avoid exposing your skin to strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.
Do not take it for longer than 7 days. If your symptoms worsen or do not improve after 7 days, talk to your doctor.
Stop taking it at least three days before taking an allergy test as it can affect the test results.
Avoid driving or operating dangerous machinery as it may decrease alertness.
Avoid consuming alcohol when taking the Metha 25mg Tablet, as it may cause excessive sleepiness or drowsiness.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Metha 25mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Metha 25mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Metha 25mg Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
For prolonged use and repeated doses of Metha 25mg Tablet, observe the baby for excessive sleepiness.

Driving

UNSAFE

Metha 25mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Metha 25mg Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.

Liver

CAUTION

Metha 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Metha with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Promethazine. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Promethazine. Please consult your doctor.

Moderate

Clozapine (Oral Route)

Watch out for symptoms such as dry mouth, increased heart rate, urination difficulties, constipation, loss of appetite or nausea and consult your doctor if you experience them.

Moderate

Thalidomide (Oral Route)

If concurrent use is essential, watch out for symptoms of Thalidomide side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Moderate

Dalteparin (Injection Route)

Your doctor may frequently monitor your blood clotting time. Promethazine may reduce the efficacy of Dalteparin.

Frequently asked questions

Is Metha 25mg Tablet or Metha 25mg Tablet DM syrup a narcotic/opiate/pain killer?

Metha 25mg Tablet is antihistaminic drug and not a narcotic/opiate/pain killer. Patient should follow the advice of doctor regarding its use

Is Metha 25mg Tablet over the counter?

No, it is available with doctor's prescription only

Can I take Metha 25mg Tablet for a hangover/sore throat/ nausea/stomach flu/cramps/toothache/ headache/ cough/pain?

Metha 25mg Tablet is used for treatment of symptoms of allergies, but not used for hangover, sore throat, stomach flu, cramps, toothache, headache and cough. Patient should follow the advice of doctor regarding its use

Can I take Metha 25mg Tablet with Nyquil/ codeine and ibuprofen/ Tylenol/ oxycodone/ Benadryl/ Dayquil/ Zofran/codeine and Nyquil/Xanax?

Yes, but taking other medicines may alter the effects of Metha 25mg Tablet. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required

Does Metha 25mg Tablet or Metha 25mg Tablet DM make you sleepy/ get you high/make you tired?

Metha 25mg Tablet may cause these side effects which are not serious. However, always consult your doctor if you experience any of these side effects.

Fact Box

Chemical Class

Phenothiazines

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

First-Generation H1 Antihistamines

Related lab tests

Absolute Eosinophil Count

Peripheral Smear Examination

Total IgE

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1159-60.
Promethazine. Philadelphia, Pennsylvania: Wyeth Pharmaceuticals Inc. [Accessed 01 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 01 Apr. 2019] (online) Available from:

User feedback

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Twice A Day

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: General Pharmaceuticals Pvt Ltd
Address: SARA AFTAB TOWER, Holdings no. 6/1/A (5th Floor), Shamoli, Adabor, Dhaka-1207.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Metha 25mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Metha Tablet

Benefits of Metha Tablet

How to use Metha Tablet

How Metha Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tranylcypromine (Oral Route)

Clozapine (Oral Route)

Thalidomide (Oral Route)

Dalteparin (Injection Route)

Frequently asked questions

Is Metha 25mg Tablet or Metha 25mg Tablet DM syrup a narcotic/opiate/pain killer?

Is Metha 25mg Tablet over the counter?

Can I take Metha 25mg Tablet for a hangover/sore throat/ nausea/stomach flu/cramps/toothache/ headache/ cough/pain?

Can I take Metha 25mg Tablet with Nyquil/ codeine and ibuprofen/ Tylenol/ oxycodone/ Benadryl/ Dayquil/ Zofran/codeine and Nyquil/Xanax?

Does Metha 25mg Tablet or Metha 25mg Tablet DM make you sleepy/ get you high/make you tired?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Absolute Eosinophil Count

Peripheral Smear Examination

Total IgE

References

User feedback

Patients taking Metha 25mg Tablet

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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