Melphater 50mg Injection

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 02 Feb 2026 | 04:03 PM (IST)

Melphater 50mg Injection is an anti-cancer drug used in the treatment of ovarian cancer and a type of cancer of bone marrow called multiple myeloma. It may also be used to treat other conditions, as determined by the doctor.

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Stored between 2-8°C

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General Information

Contains

Melphalan (50mg)

Marketer

Therdose Pharma Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Melphater 50mg Injection is administered by a doctor or a nurse into the vein. Do not self administer this medicine at home. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes skin more sensitive towards sunlight, wear protective clothing or use sunscreen.

The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells) and hair loss. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Inform your doctor if you observe signs of infections such as fever, chills, body ache or if you have unusual bruising or bleeding and bleeding gums or blood in your urine or stool.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Melphater Injection

Benefits of Melphater Injection

Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Melphater 50mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. So, you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Melphater Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Melphater

Hair loss
Low blood platelets
Diarrhea
Decreased white blood cell count
Nausea
Vomiting
Stomatitis (Inflammation of the mouth)
Anemia (low number of red blood cells)

How to use Melphater Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Melphater Injection works

Melphater 50mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

All substitutes for Melphater 50mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Synstim 50mg Injection

by Zydus Lifesciences Ltd

₹2807/injection

33% cheaper

Alphalan 50mg Injection

by Natco Pharma Ltd

₹1684/injection

60% cheaper

Quick tips

Melphater 50mg Injection should be taken as per dose and duration suggested by the doctor.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Melphater 50mg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Melphater 50mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Melphater 50mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Melphater 50mg Injection may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Melphater 50mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Melphater 50mg Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Melphater with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Melphalan. Melphalan may reduce the efficacy of Filgrastim.

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Melphalan with Cholera Vaccine (Inactivated). If Cholera Vaccine (Inactivated) is essential, ensure a gap of At least 6 months after discontinuing Melphalan. Please consult your doctor. Melphalan may reduce efficacy of Cholera Vaccine (Inactivated).

Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Melphalan with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) is essential, ensure a gap of At least 6 months after discontinuing Melphalan. Please consult your doctor. Melphalan may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Melphalan with Purified Vi Polysaccharide Typhoid Vaccine. If Purified Vi Polysaccharide Typhoid Vaccine is essential, ensure a gap of At least 6 months after discontinuing Melphalan. Please consult your doctor. Melphalan may reduce efficacy of Purified Vi Polysaccharide Typhoid Vaccine.

Severe

Pegfilgrastim (Injection Route)

Do not consume Pegfilgrastim from 24 hours before or 24 hours after taking Melphalan. Melphalan may reduce the efficacy of Pegfilgrastim.

Frequently asked questions

What is Melphater 50mg Injection usually given for?

Melphater 50mg Injection is used to treat certain cancers, mainly multiple myeloma and ovarian cancer. Doctors may use it alone or with other cancer medicines, depending on the treatment plan.

Who should not receive Melphater 50mg Injection?

Individuals should not receive Melphater 50mg Injection if they are allergic to melphalan or its ingredients, are not able to safely receive medicines that suppress the bone marrow, or are experiencing severe infections or already have dangerously low blood counts. Your doctor will check these before starting treatment.

Why do doctors monitor blood counts so closely with Melphater 50mg Injection?

Melphater 50mg Injection can significantly lower white cells, red cells, and platelets, which may increase the risk of infection, anemia, and bleeding. This medicine can sometimes be delayed, so monitoring continues for weeks after each dose.

Can Melphater 50mg Injection affect my risk of infections?

Yes. Because Melphater 50mg Injection weakens the immune system, you may be more likely to get infections or have infections become serious quickly. Fever, chills, sore throat, or flu-like symptoms should be reported immediately.

What serious side effects of Melphater 50mg Injection need immediate medical attention?

Serious side effects of Melphater 50mg Injection can include unusual bleeding or bruising, trouble breathing, fever, or signs of infection, severe tiredness, allergic reactions such as rash, swelling, or difficulty breathing. These symptoms can signal bone marrow suppression or severe hypersensitivity, and you should seek immediate medical attention if you experience any of them.

Can Melphater 50mg Injection cause long-term complications?

Melphater 50mg Injection may increase the risk of secondary cancers, especially leukemia, months, or years later. This is a known but uncommon risk with many chemotherapy medicines. Doctors use the lowest effective dose to reduce this risk.

Is Melphater 50mg Injection safe for people with kidney problems?

Kidney function affects how Melphater 50mg Injection is cleared from the body. People with kidney impairment may have stronger side effects, so doctors often use lower doses and monitor kidney tests closely.

Why do I need to stay well-hydrated during Melphater 50mg Injection treatment?

During Melphater 50mg Injection treatment, hydration supports kidney function and helps your body handle the breakdown products from cancer cell destruction, reducing the risk of complications like kidney strain. Your doctor and care team may give IV fluids if needed.

Can Melphater 50mg Injection affect my fertility?

Yes. Melphater 50mg Injection may reduce fertility in both men and women. Patients may be offered sperm or egg preservation options before starting treatment. This conversation usually happens early in the cancer-care process.

What precautions should I follow after getting Melphater 50mg Injection?

After getting Melphater 50mg Injection, your care team may advise avoiding sick contacts, watching for fever or bleeding, reporting skin changes or rashes, and keeping all blood-test appointments. These help detect complications early and keep treatment safe.

Fact Box

Chemical Class

Phenylalanine derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

Related lab tests

Albumin/Globulin Ratio, Serum

Calcium

Complete Blood Count

Kidney Function Test

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 860-61.
Mephalan. Dublin, Ireland: Aspen; 2004 [revised Aug. 2014]. [Accessed 26 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Therdose Pharma Pvt Ltd
Address: Plot No's : 118 - 120, Road No.6, ALEAP IE, Pragathi Nagar, Gajularamaram Village, Kukatpally, Hyderabad ,Telangana - 500 072, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Melphater 50mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Melphater 50mg Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Melphater Injection

Benefits of Melphater Injection

Side effects of Melphater Injection

How to use Melphater Injection

How Melphater Injection works

All substitutes for Melphater 50mg Injection

Synstim 50mg Injection

Alphalan 50mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Filgrastim (Injection Route)

Cholera Vaccine (Inactivated) (Oral Route)

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Pegfilgrastim (Injection Route)

Frequently asked questions

What is Melphater 50mg Injection usually given for?

Who should not receive Melphater 50mg Injection?

Why do doctors monitor blood counts so closely with Melphater 50mg Injection?

Can Melphater 50mg Injection affect my risk of infections?

What serious side effects of Melphater 50mg Injection need immediate medical attention?

Can Melphater 50mg Injection cause long-term complications?

Is Melphater 50mg Injection safe for people with kidney problems?

Why do I need to stay well-hydrated during Melphater 50mg Injection treatment?

Can Melphater 50mg Injection affect my fertility?

What precautions should I follow after getting Melphater 50mg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Albumin/Globulin Ratio, Serum

Calcium

Complete Blood Count

Kidney Function Test

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests