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Composition FOR MEGVAL

Melphalan(50 mg)

food interaction for MEGVAL

alcohol interaction for MEGVAL

pregnancy interaction for MEGVAL

lactation interaction for MEGVAL

It is better to take Megval 50mg injection empty stomach (1 hour before food or 2 hours after food).
Interaction with alcohol is unknown. Please consult your doctor.
Megval 50mg injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Megval 50mg injection is probably unsafe to use during breastfeeding. Please consult your doctor.


Melphalan(50 mg)


Megval 50mg injection is used in the treatment of multiple myeloma (a type of blood cancer)

How it works

Megval 50mg injection works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Common side effects

Rash, Reduced blood platelets, Headache, Fainting, Dizziness, Back pain, Convulsion, Palpitations, Myelosuppression, Coordination disorder, Increased magnesium level in blood, Shortness of breath, Pale colored skin, Yellow discoloration of eye, Stomach pain / epigastric pain, Vomiting, Weakness, Insomnia, Sleepiness, Mouth ulcer, Nausea, Decreased potassium level in blood, Abdominal pain, Infection, Loss of appetite, Bone-marrow suppression, Brain swelling, Decreased white blood cell count, Yellow discoloration of skin, Cns toxicity, Hair loss, Absence of menstrual periods, Fatigue, Sore throat, Fever, Anxiety, Increased liver enzymes, Anemia, Sore mouth, Hallucination, Thrombophlebitis, Itching, Diarrhoea, Blood in urine, Depression, Vertigo, Speech disorder, Difficulty in swalloing, Weight loss, Dark colored urine, Unusual lumps or masses, Confusion, Mucosal inflammation, Drowsiness, Gastritis, Urticaria, Decreased white blood cell count (neutrophils), Constipation, Stomatitis, Uncoordinated body movements, Decreased white blood cell count (lymphocytes), Viral infection, Increased glucose level in blood


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Expert advice FOR MEGVAL

  • Melphalan to be taken on an empty stomach 1 hour before or 2 hours after meals. Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise. 
  • You may be at risk of infection so try to avoid contact with people with cold, fever or any other signs of infection. 
  • Avoid exposure to sunlight. Use sunscreen lotion and protective clothing. 
  • You may be monitored periodically for complete blood counts (at least one determination prior to each treatment course) during the course of treatment.
  • Melphalan may increase the risk that you will develop other cancers. Talk with your doctor about the risks of taking melphalan.
  • Do not take live vaccines if you are an immunocompromised patient.
  • Use of melphalan is not recommended in children.
  • Use with melphalan extreme caution if your bone marrow reserve have been compromised by prior irradiation or chemotherapy, or if your marrow function is recovering from previous cytotoxic therapy.
  • Use appropriate contraceptive methods to avoid pregnancy during melphalan treatment.

Frequently asked questions FOR MEGVAL



Is melphalan a vesicant (irritant)?
Melphalan is not a vesicant but an anti-cancer drug


How is melphalan given?
Melphalan is given by oral or intravenous route; dosing varies by purpose and route of administration as well as patient weight


Does melphalan cause hair loss/ neuropathy/ liver damage?
Melphalan causes hair loss as one of the side effects. but cause for liver damage and neuropathy is not known

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How does melphalan work/ how does melphalan kill cancer cells?
Melphalan belongs to class of drugs called alkylating agents. It works by stopping or slowing the growth of cancer cells in your body.


Content on this page was last updated on 03 February, 2017, by Dr. Varun Gupta (MD Pharmacology)