Lafex 37.5mg Tablet ER

Prescription Required
SALT COMPOSITION
Storage
Store below 30°C

Introduction

Lafex 37.5mg Tablet ER is used in the treatment of depression and anxiety disorder. It alters the chemicals in the brain that cause symptoms of anxiety such as irritability, restlessness, lack of concentration, fatigue, sweating, increased heart rate, and unwanted or racing thoughts.

Lafex 37.5mg Tablet ER should be taken with food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly as it may worsen your symptoms.

Some common side effects of this medicine include nausea, vomiting, insomnia (difficulty in sleeping), decreased appetite, anxiety, constipation, increased sweating, and sexual dysfunction. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.

Before taking Lafex 37.5mg Tablet ER, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.

Uses of Lafex Tablet ER

Benefits of Lafex Tablet ER

In Depression

Lafex 37.5mg Tablet ER helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. This improves your mood, relieves anxiety, tension, helps you sleep better, and increases your energy levels. Lafex 37.5mg Tablet ER prevents extreme mood changes and helps you feel less agitated. You may experience fewer episodes of depression and low mood.

In Anxiety disorder

Lafex 37.5mg Tablet ER works by stopping your brain from releasing the chemicals that make you feel anxious so it can reduce the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, irritability, and sleep problems that often come with Anxiety disorder. It will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.

Side effects of Lafex Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Lafex

  • Nausea
  • Vomiting
  • Dizziness
  • Insomnia (difficulty in sleeping)
  • Decreased appetite
  • Anxiety
  • Constipation
  • Increased sweating
  • Sexual dysfunction

How to use Lafex Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lafex 37.5mg Tablet ER is to be taken with food.

How Lafex Tablet ER works

Lafex 37.5mg Tablet ER works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance.

Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Lafex 37.5mg Tablet ER.
Pregnancy
CONSULT YOUR DOCTOR
Lafex 37.5mg Tablet ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Lafex 37.5mg Tablet ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Babies should be monitored for excessive sleepiness and adequate weight gain.
Driving
UNSAFE
Lafex 37.5mg Tablet ER may cause side effects which could affect your ability to drive.
As side effects of Lafex 37.5mg Tablet ER are dizziness, confusion and eye sight changes such as blurred vision and this may affect your ability to drive.
Kidney
CAUTION
Lafex 37.5mg Tablet ER should be used with caution in patients with kidney disease. Dose adjustment of Lafex 37.5mg Tablet ER may be needed. Please consult your doctor.
Liver
CAUTION
Lafex 37.5mg Tablet ER should be used with caution in patients with liver disease. Dose adjustment of Lafex 37.5mg Tablet ER may be needed. Please consult your doctor.

What if you forget to take Lafex Tablet ER?

If you miss a dose of Lafex 37.5mg Tablet ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Lafex 37.5mg Tablet ER
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Foxard 37.5mg Tablet ER
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Quick tips

  • Lafex 37.5mg Tablet ER helps in treating depression and anxiety.
  • It may take 2 to 4 weeks for Lafex 37.5mg Tablet ER to start working. Keep taking it as prescribed.
  • It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking Lafex 37.5mg Tablet ER as it may cause excessive drowsiness and increase the risk of liver damage.
  • It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Do not stop taking the medication suddenly without talking to your doctor.

Fact Box

Chemical Class
Anisole Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Interaction with drugs

Taking Lafex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Lizolan, Lidoford, Zenlid
LIFE-THREATENING
Brand(s): Trima, Rimarex, Morex
LIFE-THREATENING
Brand(s): Rasalect, Relgin, Rasipar
LIFE-THREATENING
Brand(s): Selgelin
LIFE-THREATENING

Patient concerns

arrow
Mental Depression , Anxiety disorder
Dr. Jyoti Kapoor Madan
Psychiatry
Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.
Mixed anxiety depressive disorder
Dr. Jyoti Kapoor Madan
Psychiatry
Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.
arrow

FAQs

Q. Can Lafex 37.5mg Tablet ER cause sedation?

Yes. Lafex 37.5mg Tablet ER can cause sedation. You should inform your doctor if you are taking any other sleep inducing medicines before starting Lafex 37.5mg Tablet ER.

Q. Is Lafex 37.5mg Tablet ER a psychotropic drug?

Yes. Lafex 37.5mg Tablet ER is a psychotropic drug. Any medication capable of affecting the mind, emotions, and behaviour are called psychotropic drugs.

Q. Is Lafex 37.5mg Tablet ER a narcotic?

No. Lafex 37.5mg Tablet ER is not a narcotic drug. Narcotics are drugs with sleep inducing properties, usual derivatives of Opium like Heroin and Morphine.

Q. What is the difference between Lafex 37.5mg Tablet ER ER and XR?

Both are same medication. Lafex 37.5mg Tablet ER ER and XR both means extended release preparation which releases the medication slowly into the body and maintains a constant needed medications levels. The advantage of taking ER/XR tablets is the frequency of dosage can be decreased.

Q. Can I take mirtazapine along with Lafex 37.5mg Tablet ER?

No. There can be a serious side effect when mirtazapine is taken with Lafex 37.5mg Tablet ER. It can cause a serious condition called as serotonin syndrome. It is a potentially life-threatening can present as agitation, hallucinations, nausea, vomiting, diarrhoea, tachycardia, labile blood pressure, hyperthermia and coma.

Q. Can I take Lafex 37.5mg Tablet ER with citalopram?

No. Citalopram and Lafex 37.5mg Tablet ER both increase serotonin levels. Avoid or use any alternate drug. It can cause a serious condition called as serotonin syndrome. It is a potentially life-threatening can present as agitation, hallucinations, nausea, vomiting, diarrhoea, tachycardia, labile blood pressure, hyperthermia and coma.

Q. What is the relation between Lafex 37.5mg Tablet ER and p-glycoprotein?

P-glycoprotein is responsible for the expulsion of Lafex 37.5mg Tablet ER from the brain. Some studies have shown that Lafex 37.5mg Tablet ER and its metabolite inhibit the p-glycoprotein.

Q. Where is Lafex 37.5mg Tablet ER absorbed?

Lafex 37.5mg Tablet ER is absorbed from the intestine after being metabolised by the liver.

Q. When should I take Lafex 37.5mg Tablet ER?

Lafex 37.5mg Tablet ER is a medication to treat generalised depressive disorder or depression. Consult your doctor before taking this medication.

Q. Can Lafex 37.5mg Tablet ER cause high blood pressure?

Lafex 37.5mg Tablet ER treatment is associated with sustained increases in blood pressure in some people. It is recommended that people who are being treated with Lafex 37.5mg Tablet ER should have regular monitoring of blood pressure. For such people, either dose reduction or discontinuation should be considered.

Q. Can Lafex 37.5mg Tablet ER cause constipation?

Yes. Lafex 37.5mg Tablet ER is known to cause constipation in some patients. Take a fiber-rich diet and drink plenty of water. You may consider taking laxatives as well. Your doctor will suggest ways to prevent or manage it. Please consult your doctor if it does not resolve or gets worse.

Q. Can Lafex 37.5mg Tablet ER cause weight loss?

Yes. Lafex 37.5mg Tablet ER is known to cause weight loss in some patients. In research studies, a dose-dependent weight loss was noted in patients treated with Lafex 37.5mg Tablet ER for several weeks. Please consult your doctor if it bothers you.

Q. Can Lafex 37.5mg Tablet ER cause addiction?

No. Lafex 37.5mg Tablet ER does not have habit-forming potential.

Q. Can I take Lafex 37.5mg Tablet ER tablet instead of a capsule?

You can take a tablet instead of the capsule but only under consultation or prescription of a doctor. You should not change it yourself as the different formulation of a medication may have a different action as drug release would be different in both. This can lead to an inappropriate treatment and may lead to side effects or even failure of treatment.

Q. Can gabapentin be given along with Lafex 37.5mg Tablet ER?

Yes. Gabapentin can be given with Lafex 37.5mg Tablet ER but only with a consultation of a doctor. They both, when given together, causes an increase drowsiness, sleepiness and decreased concentration in work. Take with caution.

Q. What is the difference between Lafex 37.5mg Tablet ER and desvenlafaxine?

Desvenlafaxine is an active metabolite of Lafex 37.5mg Tablet ER. It is the same medication in an active form.

Q. Can fibromyalgia be treated with Lafex 37.5mg Tablet ER?

Lafex 37.5mg Tablet ER is not approved for the treatment of fibromyalgia. Some research studies have shown promising results of Lafex 37.5mg Tablet ER in the treatment of fibromyalgia. Consult your doctor before starting this medication.

Q. Can nerve pain be treated with Lafex 37.5mg Tablet ER?

Lafex 37.5mg Tablet ER is not approved for treatment of nerve pain disorders but some researchers have proved its efficacy in nerve pain. It is currently used off-label for nerve pain.

Q. Why does Lafex 37.5mg Tablet ER cause loss of appetite?

Lafex 37.5mg Tablet ER is known to cause changes in the neurotransmitters levels and chemicals in the brain which leads to decrease in appetite and this loss of appetite is dose dependent.

Q. What are good alternatives to Lafex 37.5mg Tablet ER, particularly when a side effect is reduced sex drive?

If you find any side effects like decreased sex drive or impotence talk to your doctor and then you can have some other drug. Do not stop Lafex 37.5mg Tablet ER by yourself it can lead to increased adverse effects.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Stahl SM, editor. Venlafaxine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 721-26.
  2. DeBattista C. Antidepressant Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 513.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1466.
  4. Venlafaxine [FDA Label]. Marietta, GA: Urban Pharmaceuticals Inc.; 1993 [revised Jun. 2014]. [Accessed 19 Mar. 2019] (online) Available from:External Link
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Venlafaxine. [Updated 2019 Oct 23]. [Accessed 20 Feb. 2020] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:External Link

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Door No.1406, 17-A Main 1 B Cross J.P. Nagar Bangalore Bangalore KA 560078 IN
Country of origin: India

Expires on or after: August, 2022

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