Kucil 500mg Injection

Fluorouracil (500mg)

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Kucil 500mg Injection is used in the treatment of cancers of stomach, colon, rectum, breast, and lungs. It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

₹19.3 MRP ₹20.968% off

Gurgaon

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General Information

Contains

Fluorouracil (500mg)

Marketer

Khandelwal Laboratories Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Kucil 500mg Injection is given as injection under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include increased risk of infection, mouth ulcer, vomiting, weakness, and nausea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Kucil Injection

Cancer

Benefits of Kucil Injection

Cancer
Kucil 500mg Injection helps to treat certain kinds of cancer such as cancer of the breasts, lungs, colon, rectum etc. It may be used alone or in combination with other medicines to treat cancer in various parts of the body. Kucil 500mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Kucil Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Kucil

Nausea
Vomiting
Hair loss
Diarrhea
Bronchospasm
Infection
Myelosuppression
Agranulocytosis (deficiency of granulocytes in the blood)
General discomfort
Itching
Skin exfoliation
Anemia (low number of red blood cells)
Febrile neutropenia
Angina (heart related chest pain)
ECG changes
Decreased immunity

How to use Kucil Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Kucil Injection works

Kucil 500mg Injection is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Quick tips

Kucil 500mg Injection helps treat cancers of stomach, colon, rectum, breast, and lungs.
It is given as an injection into a vein, or as a drip (infusion) into a vein or artery.
The dose and the number of treatment cycles needed will depend on the type and stage of cancer that is being treated.
It may cause dizziness and visual changes. Do not drive or do anything requiring concentration until you know how it affects you.
Your doctor may regularly monitor your blood cells and liver function during treatment with this medicine.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Kucil 500mg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Kucil 500mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Kucil 500mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Kucil 500mg Injection may cause side effects that could affect your ability to drive.
Kucil 500mg Injection can cause side effects such as nausea and can also produce adverse events on your nervous system which cause visual changes.This may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Kucil 500mg Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

CAUTION

Kucil 500mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Kucil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Fluorouracil. Fluorouracil may reduce the efficacy of Filgrastim.

Severe

Pegfilgrastim (Injection Route)

Do not consume Pegfilgrastim from 24 hours before or 24 hours after taking Fluorouracil. Fluorouracil may reduce the efficacy of Pegfilgrastim.

Severe

Sargramostim (Injection Route)

Do not consume Sargramostim from 24 hours before or 24 hours after taking Fluorouracil. Fluorouracil may reduce the efficacy of Sargramostim.

Severe

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before or 24 hours after taking Fluorouracil. Fluorouracil may reduce the efficacy of Lenograstim.

Severe

Molgramostim (Injection Route)

Do not consume Molgramostim from 24 hours before or 24 hours after taking Fluorouracil. Please consult with your doctor. Fluorouracil may reduce the efficacy of Molgramostim.

Frequently asked questions

Is fluorouracil a vesicant?

No, fluorouracil is not a vesicant (irritant).

Is fluorouracil safe?

Fluorouracil is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Is fluorouracil a steroid?

No, flurouracil is not a steroid.

Is fluorouracil cream chemotherapy?

Fluorouracil is used as chemotherapy for the treatment of cancers.

Is fluorouracil cream for warts?

Yes, fluorouracil is used for the treatment of warts.

Is fluorouracil the same as efudex?

Efudex is a brand name (trade name) for fluorouracil.

Does fluorouracil affect normal skin?

Fluorouracil has minimal effect on the surrounding healthy skin.

Does fluorouracil cause hair loss?

Yes, fluorouracil may cause temporary hair loss.

Does fluorouracil cause scarring?

No, fluorouracil is not known to cause scarring.

Does fluorouracil cause headaches?

Though headache is not a common side effect of fluorouracil, it may occur uncommonly is some people.

Why does fluorouracil cause fatigue?

As with any chemotherapy for cancer, fluorouracil causes fatigue which is attributed to be of multi-factor origin, but inflammation and anemia are thought to be the most important factors.

Fact Box

Chemical Class

Halopyrimidines

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolites

References

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 946-47.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 561-63.
Fluorouracil. Hurley, Maidenhead: Hospira UK Ltd.; 1985 [revised Jan. 2017]. [Accessed 29 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Fluorouracil. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Khandelwal Laboratories Pvt Ltd
Address: KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA

Vendor Details

Country of origin: India

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Why we need a prescription?

Kucil 500mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Kucil Injection

Benefits of Kucil Injection

Side effects of Kucil Injection

How to use Kucil Injection

How Kucil Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Filgrastim (Injection Route)

Pegfilgrastim (Injection Route)

Sargramostim (Injection Route)

Lenograstim (Injection Route)

Molgramostim (Injection Route)

Frequently asked questions

Is fluorouracil a vesicant?

Is fluorouracil safe?

Is fluorouracil a steroid?

Is fluorouracil cream chemotherapy?

Is fluorouracil cream for warts?

Is fluorouracil the same as efudex?

Does fluorouracil affect normal skin?

Does fluorouracil cause hair loss?

Does fluorouracil cause scarring?

Does fluorouracil cause headaches?

Why does fluorouracil cause fatigue?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Kucil Injection for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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