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Isonit Plus Tablet is used in the treatment of heart failure. It is a combination of two medicines that effectively control symptoms of heart failure.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 02 Feb 2026 | 11:11 AM (IST)
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General Information

Contains

Isosorbide Dinitrate (20mg)+ Hydralazine (37.5mg)

Marketer

Tas Med India Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Isonit Plus Tablet image
Isonit Plus Tablet image
Isonit Plus Tablet image
Isonit Plus Tablet image
Isonit Plus Tablet image

Product introduction

Isonit Plus Tablet should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like a low-fat diet, exercise, and not smoking may help this medicine to work better.

It is generally safe and suitable for most people but has some potential side effects. The most common side effects of this medicine include nausea, vomiting, diarrhea, low blood pressure, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes you feel dizzy as of orthostatic hypotension (sudden lowering of blood pressure on standing). Hence, rise slowly while from a sitting position or avoid driving. You may be asked for regular monitoring of blood pressure while on the treatment.

Before taking this medicine, tell your doctor if you have liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.

Uses of Isonit Plus Tablet

Benefits of Isonit Plus Tablet

Treatment of Heart Failure
Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Isonit Plus Tablet makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure.
This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes, such as eating healthy and keeping active, to help this medicine be effective. Take it regularly and keep taking it even if you feel better.

Side effects of Isonit Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Isonit Plus
  • Nausea
  • Headache
  • Dizziness
  • Weakness
  • Ventricular tachycardia
  • Paralysis of ileus
  • Hypotension (low blood pressure)
  • Visual impairment

How to use Isonit Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isonit Plus Tablet should be taken with or after food.

How Isonit Plus Tablet works

Isonit Plus Tablet is a combination of two medicines:

All substitutes for Isonit Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

APREsol Plus Tablet

by Ordain Health Care Global Pvt Ltd
₹10.5/tablet
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<h3 class=bodySemiBold>APREsol Plus Tablet</h3>

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Nitrohart Tablet

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<h3 class=bodySemiBold>Nitrohart Tablet</h3>

Isorus Tablet

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<h3 class=bodySemiBold>Isorus Tablet</h3>

Sorba HF 20mg/37.5mg Tablet

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<h3 class=bodySemiBold>Sorba HF 20mg/37.5mg Tablet</h3>

Quick tips

  • Isonit Plus Tablet is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
  • This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
  • Isonit Plus Tablet may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • It is best to avoid drinking alcohol while taking Isonit Plus Tablet as it may make the side effects worse.
  • Do not take it in combination with  medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.
  • Do not stop taking Isonit Plus Tablet suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Isonit Plus Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

UNSAFE
Isonit Plus Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.
Driving

Driving

CAUTION
Isonit Plus Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
As Isonit Plus Tablet may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
Kidney

Kidney

CAUTION
Isonit Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of blood pressure is recommended for better dose adjustment.
Liver

Liver

CAUTION
Isonit Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

No, keep using Isonit Plus Tablet as advised by your doctor, even if you feel well. Stopping Isonit Plus Tablet suddenly may lead to serious complications of heart failure.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Isonit Plus Tablet can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.
Yes, the use of Isosorbide Isonit Plus Tablet can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.

Fact Box

Habit Forming

No

Therapeutic Class

CARDIAC

References

  1. Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9. [Accessed 21 Jan. 2019] (online) Available from:
  2. Mastanamma SK, Saidulu P, Sravanthi A, et al. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;40(1):1411-48. [Accessed 21 Jan. 2019] (online) Available from:
  3. Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78. [Accessed 21 Jan. 2019] (online) Available from:
  4. Isosorbide dinitrate and hydralazine hydrochloride. Seymour, Indiana: Kremers Urban Pharmaceuticals Inc.; 2005 [revised Apr. 2015]. [Accessed 23 Jan. 2019] (online) Available from:
  5. Isosorbide dinitrate and hydralazine hydrochloride [Prescribing Inforamtion]. Seymour, IN: Kremers Urban Pharmaceuticals Inc.; 2015. [Accessed 28th Sept. 2023] (online) Available from:
  6. Central Drugs Standard Control Organization. Isosorbide Dinitrate+Hydralazine. [Accessed 28th Sept. 2023] (online) Available from:
  7. ScienceDirect. Isosorbide Dinitrate. [Accessed 28th Sept. 2023] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Tas Med India Pvt Ltd
Address: Plot No. 45, N.T.M., Sector -26, Chandigarh

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Isonit Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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