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MDS (Oral Pathology & Microbiology), BDS
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12 Jun 2019 | 11:53 AM (IST)
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Apresol Plus Tablet is used in the treatment of heart failure. It is a combination of two medicines that effectively controls symptoms of heart failure. This medicine should be taken regularly with or without food at a fixed time each day. It should not be stopped abruptly and taken strictly as advised by your doctor. Lifestyle changes like low-fat diet, exercise, and not smoking may help this medicine work better. Side effects like chest pain, decrease blood pressure, and increased heart rate may occur in some patients. It may also produce dizziness and headache initially, but these improve with time.

Uses of Apresol Plus Tablet

Apresol Plus Tablet side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Headache
  • Flushing of face
  • Dizziness
  • Increased heart rate
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Chest pain
  • Drug-induced lupus syndrome
  • Palpitations
  • Decreased blood pressure
  • Swelling of hands
  • Swelling of feet

How to use Apresol Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apresol Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Apresol Plus Tablet works

Apresol Plus Tablet is a combination of two medicines: Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate is a nitrate which relaxes the blood vessels and decreases the oxygen demand of the heart. Hydralazine is a potassium channel opener which acts as an antioxidant and lessens tolerance to isosorbide dinitrate, thereby preserving its capacity to relax blood vessels. Together, they improve symptoms of heart failure.

Apresol Plus Tablet related warnings

Apresol Plus Tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
Apresol Plus Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Apresol Plus Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Do not drive unless you are feeling well.
As Apresol Plus Tablet may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
Apresol Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Apresol Plus Tablet may be needed. Please consult your doctor.
Regular monitoring of blood pressure is recommended for better dose adjustment.
Apresol Plus Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Apresol Plus Tablet may not be needed in these patients. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Apresol Plus Tablet
Muzika 20mg/37.5mg Tablet
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Expert Advice

  • Apresol Plus Tablet is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
  • This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
  • Apresol Plus Tablet may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • It is best to avoid drinking alcohol while taking Apresol Plus Tablet as it may make the side effects worse.
  • Do not take it in combination with  medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.
  • Do not stop taking Apresol Plus Tablet suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.

Patient Concerns

Questions Related to Apresol Plus

ozomet pg2 was given by doctor is it good?? or shall i have ozomet vg2?? what is the difference between twoideal TD vitamin tablet any substitute can i have??Voglibose or Pioglitazone ??? which is less in side effect?? for the age of 48!!
Dr. Sfurti Mann
Diabetes Specialist
Voglibose and pioglitazone both are medications used for diabetes but there mechanism of action is different and so are their side effects. Voglibose acts to reduce post prandial blood glucose whereas pioglitazone improves insulin sensitivity and improves glycemic control. Voglibose causes gastric side effects and sometimes affects the liver whereas pioglitazone should not be given to patients with heart ailments as it can worsen heart failure.
What for Nefrosave tablet is recommended ???
Dr. Sanjay Bhatt
Diabetes Specialist
Nefrosave Tablet Uses Nefrosave Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: High Blood Pressure Join 148 Pro Subscribers Hereditary Disorder Affecting The Exocrine Glands Hepatitis Join 48 Pro Subscribers Carbon Tetrachloride Poisoning Join 75 Pro Subscribers Acute Bronchitis Join 74 Pro Subscribers Chronic Bronchitis Paracetamol Poisoning Congestive Heart Failure High Cholesterol
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Q. Can I stop taking Apresol Plus if I feel well?

No, keep using Apresol Plus as advised by your doctor, even if you feel well. Stopping Apresol Plus suddenly may lead to serious complications of heart failure.

Q. Are there any special instructions regarding storage and disposal of this medicine?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Apresol Plus cause headache?

Apresol Plus can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.

Q. Can the use of Apresol Plus cause dizziness?

Yes, the use of Isosorbide Apresol Plus can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
  1. Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9. [Accessed 21 Jan. 2019] (online) Available from:External Link
  2. Mastanamma SK, Saidulu P, Sravanthi A, et al. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;40(1):1411-48. [Accessed 21 Jan. 2019] (online) Available from:External Link
  3. Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78. [Accessed 21 Jan. 2019] (online) Available from:External Link
  4. Isosorbide dinitrate and hydralazine hydrochloride. Seymour, Indiana: Kremers Urban Pharmaceuticals Inc.; 2005 [revised Apr. 2015]. [Accessed 23 Jan. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Exeltis - Ordain Health Care Global Pvt Ltd , Khivraj Complex - II, 4th Floor, No: 480, Anna Salai, Nandanam, Chennai - 600 035, Tamil Nadu, India.
A licensed pharmacy from your nearest location will deliver Apresol Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
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