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Nitrohart Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 03:07 PM (IST)
Nitrohart Tablet is used in the treatment of heart failure. It is a combination of two medicines that effectively control symptoms of heart failure.
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General Information

Contains

Isosorbide Dinitrate (20mg)+ Hydralazine (37.5mg)

Marketer

Mankind Pharma Ltd

Storage

Store below 30°C
The content is shown in English
Nitrohart Tablet image
Nitrohart Tablet image
Nitrohart Tablet image
Nitrohart Tablet image
Nitrohart Tablet image
Nitrohart Tablet image

Product introduction

Nitrohart Tablet should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like a low-fat diet, exercise, and not smoking may help this medicine to work better.

It is generally safe and suitable for most people but has some potential side effects. The most common side effects of this medicine include nausea, vomiting, diarrhea, low blood pressure, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes you feel dizzy as of orthostatic hypotension (sudden lowering of blood pressure on standing). Hence, rise slowly while from a sitting position or avoid driving. You may be asked for regular monitoring of blood pressure while on the treatment.

Before taking this medicine, tell your doctor if you have liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.

Uses of Nitrohart Tablet

Benefits of Nitrohart Tablet

Treatment of Heart Failure
Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Nitrohart Tablet makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure.
This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes, such as eating healthy and keeping active, to help this medicine be effective. Take it regularly and keep taking it even if you feel better.

Side effects of Nitrohart Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nitrohart
  • Nausea
  • Headache
  • Dizziness
  • Weakness
  • Ventricular tachycardia
  • Paralysis of ileus
  • Hypotension (low blood pressure)
  • Visual impairment

How to use Nitrohart Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nitrohart Tablet should be taken with or after food.

How Nitrohart Tablet works

Nitrohart Tablet is a combination of two medicines:.

All substitutes for Nitrohart Tablet

For information purposes only. Consult a doctor before taking any medicine.

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Quick tips

  • Nitrohart Tablet is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
  • This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
  • Nitrohart Tablet may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • It is best to avoid drinking alcohol while taking Nitrohart Tablet as it may make the side effects worse.
  • Do not take it in combination with  medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.
  • Do not stop taking Nitrohart Tablet suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.

Safety advice

Alcohol

Alcohol

UNSAFE
Consumption of alcohol with Nitrohart Tablet may cause a disulfiram-like reaction, leading to symptoms such as flushing, increased heart rate, low blood pressure, nausea, lightheadedness, and severe headache.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Nitrohart Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Nitrohart Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

UNSAFE
Nitrohart Tablet may cause side effects that could affect your ability to drive.
As Nitrohart Tablet may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
Kidney

Kidney

CAUTION
Nitrohart Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Regular monitoring of blood pressure is recommended for better dose adjustment.
Liver

Liver

SAFE IF PRESCRIBED
Nitrohart Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Frequently asked questions

No, keep using Nitrohart Tablet as advised by your doctor, even if you feel well. Stopping Nitrohart Tablet suddenly may lead to serious complications of heart failure.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Nitrohart Tablet can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.
Yes, the use of Isosorbide Nitrohart Tablet can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.

Fact Box

Habit Forming

No

Therapeutic Class

CARDIAC

References

  1. Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9. [Accessed 21 Jan. 2019] (online) Available from:
  2. Mastanamma SK, Saidulu P, Sravanthi A, et al. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;40(1):1411-48. [Accessed 21 Jan. 2019] (online) Available from:
  3. Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78. [Accessed 21 Jan. 2019] (online) Available from:
  4. Isosorbide dinitrate and hydralazine hydrochloride. Seymour, Indiana: Kremers Urban Pharmaceuticals Inc.; 2005 [revised Apr. 2015]. [Accessed 23 Jan. 2019] (online) Available from:
  5. Isosorbide dinitrate and hydralazine hydrochloride [Prescribing Inforamtion]. Seymour, IN: Kremers Urban Pharmaceuticals Inc.; 2015. [Accessed 28th Sept. 2023] (online) Available from:
  6. Central Drugs Standard Control Organization. Isosorbide Dinitrate+Hydralazine. [Accessed 28th Sept. 2023] (online) Available from:
  7. ScienceDirect. Isosorbide Dinitrate. [Accessed 28th Sept. 2023] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Mankind Pharma Ltd
Address: 208, Okhla Industrial Estate, Phase III, New Delhi - 110020

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Nitrohart Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?
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Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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