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Isolazine Tablet


Overview

Introduction

Isolazine Tablet is used in the treatment of heart failure. It is a combination of two medicines that effectively controls symptoms of heart failure.

Isolazine Tablet should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like low-fat diet, exercise and not smoking may help this medicine to work better.

It is generally safe and suitable for most people but has some potential side effects. The most common side effects of this medicine include nausea, vomiting, diarrhea, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes you feel dizzy as of orthostatic hypotension (sudden lowering of blood pressure on standing). Hence, rise slowly while from sitting position or avoid driving. You may be asked for regular monitoring of blood pressure while on the treatment.

Before taking this medicine, tell your doctor if you have liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.

Uses of Isolazine Tablet

Side effects of Isolazine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Isolazine

  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Headache
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Dizziness
  • Increased heart rate
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Chest pain
  • Drug-induced lupus syndrome
  • Palpitations
  • Decreased blood pressure
  • Swelling of hands
  • Feet swelling

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.
  • Coping with Loss of appetite
    It is important to eat, even if you do not feel like it. You might try switching to smaller meals and frequent snacks. Try eating healthy and nutritious snacks that are high in calories and protein, such as dried fruit and nuts. It is important to drink even if you cannot eat. But, do not fill your stomach with liquid before eating. Eat when you are most hungry. Exercise such as a short walk may also increase your appetite. Talk to your doctor about possible medication or supplements if your condition does not improve.
  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Flushing (sense of warmth in the face, ears, neck and trunk)
    Sip cold or iced drinks. Try cutting down on coffee, tea and alcohol. It might help to keep the room cool and use a fan. You could also spray cool water on your face. Wear layers of light clothing that you can easily take off if you overheat. Breathe deeply and try to relax. Have a lukewarm shower or bath instead of a hot one. Avoid smoking and cut down on alcohol. The flushing should go away after a few days. If it does not go away or causes problems, contact your doctor. There may be medicines that can help.
  • Coping with Dizziness
    This is usually short-lived and should go away within a few days. If this happens, stop what you are doing and sit or lie down until you feel better. Lying still in a dark, quiet room may help reduce the spinning feeling. Sleep with your head slightly raised on two or more pillows. Get up slowly from a lying or sitting position. Get plenty of rest and try to relax as being anxious can make it worse. Try taking this medicine at bedtime to reduce the symptoms. Drinking plenty of water and ginger tea may also help. Avoid alcohol, caffeine and smoking as it will make you feel worse. Avoid driving or using tools or machinery until you feel better.
  • Coping with Increased heart rate
    Breathe in slowly through your nostrils and then breathe out through your mouth. Repeat this until you feel calm. Try sitting cross-legged and drink plenty of water. Splash cold water or apply a cold towel or ice pack on your face for 20-30 seconds. It is important to make sure that you are not taking more than the prescribed dose. As a preventive measure, you should limit the amount of alcohol you drink and give up smoking. Also, cut down the amount of coffee, tea or cola you drink. In general, being physically active and eating a healthy well-balanced diet is good advice for any heart condition. If the condition does not improve, consult your doctor as they may need to change you to a different type of medicine.
  • Coping with Palpitations
    If this happens regularly after you take your medicine, try to take the medicine at a time when you can sit or lie down when the symptoms are worse. It may help to cut down on alcohol, smoking, caffeine and big meals as these might make the problem worse. If you are still having problems after a week, speak to your doctor as you may be offered a different type of medicine.
  • Coping with Decreased blood pressure
    Get up slowly from a sitting or lying position. Try to avoid changing positions suddenly even in general. Try crossing your legs when you are sitting and wearing compression stockings. Drink plenty of water and try eating smaller, more frequent meals. Although salt is not good for everyone (and bad for some people), if you have low blood pressure increasing your intake of salt (sodium) can raise your blood pressure. Cut down the amount of alcohol you drink. If your blood pressure becomes very low, you should talk to your doctor.
  • Coping with Feet swelling
    Keep your legs raised when you are sitting or lying down. Try to keep moving your legs and ankles by taking a short walk several times an hour, as standing still for too long can increase swelling. Avoid wearing tight-fitting clothes and do not cross your leg. Drink plenty of non-alcoholic fluids and avoid alcohol. Reduce the salt in your diet. Losing weight and performing leg exercises while sitting can also help reduce the swelling. Using compression socks may help relieve pain and prevent fluid collection in your legs, ankles and feet.

How to use Isolazine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isolazine Tablet is to be taken with food.

How Isolazine Tablet works

Isolazine Tablet is a combination of two medicines: Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate is a nitrate which relaxes the blood vessels and decreases the oxygen demand of the heart. Hydralazine is a potassium channel opener which acts as an antioxidant and lessens tolerance to isosorbide dinitrate, thereby preserving its capacity to relax blood vessels. Together, they improve symptoms of heart failure.

Safety Advice

Alcohol
UNSAFE
Consuming alcohol while taking Isolazine Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
Isolazine Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Isolazine Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Isolazine Tablet may cause side effects which could affect your ability to drive.
As Isolazine Tablet may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
Kidney
CAUTION
Isolazine Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Isolazine Tablet may be needed. Please consult your doctor.
Regular monitoring of blood pressure is recommended for better dose adjustment.
Liver
SAFE IF PRESCRIBED
Isolazine Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Isolazine Tablet may not be needed in these patients. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • Isolazine Tablet is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
  • This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
  • Isolazine Tablet may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • It is best to avoid drinking alcohol while taking Isolazine Tablet as it may make the side effects worse.
  • Do not take it in combination with  medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.
  • Do not stop taking Isolazine Tablet suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.

Fact Box

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Patient Concerns

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Dr. Sanjay Bhatt
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Nefrosave Tablet Uses Nefrosave Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: High Blood Pressure Join 148 Pro Subscribers Hereditary Disorder Affecting The Exocrine Glands Hepatitis Join 48 Pro Subscribers Carbon Tetrachloride Poisoning Join 75 Pro Subscribers Acute Bronchitis Join 74 Pro Subscribers Chronic Bronchitis Paracetamol Poisoning Congestive Heart Failure High Cholesterol
Clotting in right leg.after trying tablet wefron2mg . Xerlton15mg is going on.but itching comes on full body. Itching not stopping.what may be reason for itching. Thodi sans bhi fulti he there ke
Dr. Pushkar Mani
Physician
kidney failure can be reason or heart attackconsult cardiologist and nephrologist
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User Feedback


FAQs

Q. Can I stop taking Isolazine if I feel well?

No, keep using Isolazine as advised by your doctor, even if you feel well. Stopping Isolazine suddenly may lead to serious complications of heart failure.

Q. Are there any special instructions regarding storage and disposal of this medicine?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Isolazine cause headache?

Isolazine can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.

Q. Can the use of Isolazine cause dizziness?

Yes, the use of Isosorbide Isolazine can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9. [Accessed 21 Jan. 2019] (online) Available from:External Link
  2. Mastanamma SK, Saidulu P, Sravanthi A, et al. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;40(1):1411-48. [Accessed 21 Jan. 2019] (online) Available from:External Link
  3. Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78. [Accessed 21 Jan. 2019] (online) Available from:External Link
  4. Isosorbide dinitrate and hydralazine hydrochloride. Seymour, Indiana: Kremers Urban Pharmaceuticals Inc.; 2005 [revised Apr. 2015]. [Accessed 23 Jan. 2019] (online) Available from:External Link

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