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IRINOTRAZ 100MG INJECTION

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MRP: Rs. 4081.63 for 1 vial(s) (5 ML injection each)
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Composition for IRINOTRAZ

Irinotecan(100 mg)

food interaction for IRINOTRAZ

alcohol interaction for IRINOTRAZ

pregnancy interaction for IRINOTRAZ

lactation interaction for IRINOTRAZ

food
alcohol
pregnancy
lactation
It can be taken with or without food, but it is better to take Irinotraz 100mg injection at a fixed time.
Avoid Irinotraz 100mg injection with grapefruit juice.
UNSAFE
Interaction with alcohol is unknown. Please consult your doctor.
Irinotraz 100mg injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Irinotraz 100mg injection is probably unsafe to use during breastfeeding. Please consult your doctor.
UNSAFE

SALT INFORMATION for IRINOTRAZ

Irinotecan(100 mg)

Uses

Irinotraz 100mg injection is used for the treatment of progressive metastatic cancer (state of cancer which spreads to other parts of body) of the large intestine (colon and rectum).

How it works

Irinotraz 100mg injection belongs to class of drugs called topoisomerase inhibitors. Irinotraz 100mg injection inhibits the action of topoisomerase. Irinotraz 100mg injection prevents religation of the DNA strand by binding to topoisomerase I-DNA complex. The formation of this ternary complex interferes with the moving replication fork, which induces replication arrest and lethal double-stranded breaks in DNA. As a result, DNA damage is not efficiently repaired and apoptosis (programmed cell death) occurs.

Common side effects

Nausea, Ankle swelling, Limb swelling, Back pain, Chest pain, Body ache, Diarrhoea, Difficulty in swalloing, Shortness of breath, Fever, Hair loss, Heartburn, Loss of appetite, Rash, Itching, Sleepiness, Sore mouth, Sore throat, Urticaria, Vomiting, Weakness, Weight loss, Yellow discoloration of skin, Yellow discoloration of eye

SUBSTITUTES for IRINOTRAZ

8 Substitutes
Sorted By
RelevancePrice
  • IRNOCAM 100MG INJECTION
    (1 injection in vial)
    Dr Reddy's Laboratories Ltd
    Rs. 3704.31/injection
    Injection
    Rs. 3704.31
    pay 354% more per injection
  • CAMPTO 100MG INJECTION
    (5 ML injection in vial)
    Pfizer Ltd
    Rs. 4047.62/ML of injection
    generic_icon
    Rs. 20238.10
    pay 396% more per ML of injection
  • IRINOTEL 100 MG INJECTION
    (5 ML injection in vial)
    Fresenius Kabi India Pvt Ltd
    Rs. 641/ML of injection
    generic_icon
    Rs. 3205
    save 21% more per ML of injection
  • IMTUS 100MG INJECTION
    (1 ML injection in vial)
    Emcure Pharmaceuticals Ltd
    Rs. 2687.50/ML of injection
    generic_icon
    Rs. 2687.50
    pay 229% more per ML of injection
  • IRICIP 100MG INJECTION
    (5 ML injection in vial)
    Cipla Ltd
    Rs. 280.22/ML of injection
    generic_icon
    Rs. 1401.09
    save 66% more per ML of injection

Expert advice for IRINOTRAZ

• You will be monitored for blood cell counts before each treatment session. 
• Seek immediate medical attention if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting or diarrhea or fever.
• Tell your doctor if you have received radiation therapy in the past.
• Inform your doctor if you have diabetes, asthma, high cholesterol or high blood pressure or any liver or kidney or heart or lung disorders. .
• Do not drive or operate any machines as irinotecan may cause drowsiness, dizziness or blurred vision.
• Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
• Patients allergic to irinotecan or any of its ingredients should not take it.
• Patients with chronic inflammatory bowel disease and or bowel obstruction should not take it.
• Patients with severe liver disease or severe bone marrow failure should not take it.
• Pregnant and breastfeeding women should avoid taking it.

Frequently asked questions for IRINOTRAZ

Irinotecan

 
Q. Is irinotecan a vesicant?
Irinotecan is not a known vesicant but a precaution should be taken to avoid severe local tissue damage upon extravasation (leaking of injected Azacitidine into the surrounding tissues from the site of administration) when injected.
 
Q. Is irinotecan chemotherapy?
Yes. Irinotecan is chemotherapy, used in the treatment of advanced colorectal cancer.
 
Q. Does Irinotecan cause hair loss?
No, Irinotecan is not known to cause hair loss.
 
Q. Why does irinotecan cause diarrhea?
Irinotecan damages rapidly dividing normal and cancer cells. Chemotherapy with irinotecan damages normal cells of gastrointestinal tract, leading to a disruption in the fluid balance that they maintain. Specifically, absorption of fluid from the gastrointestinal (GI) tract back into the body is decreased and secretion of fluid and electrolytes in the stool is increased. This causes watery bowel movements, i.e diarrhea.
 
Q. Does irinotecan cure cancer? 
No. irinotecan can improve symptoms and prolong life of a patient.

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Content on this page was last updated on 18 June, 2014, by Dr. Varun Gupta (MD Pharmacology)