Ibrunat Capsule

Ibrutinib (140mg)

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Ibrunat Capsule is used in the treatment of mantle-cell lymphoma and blood cancer (chronic lymphocytic leukemia). It is also used in chronic lymphocytic leukaemia who have received at least one prior therapy.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

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Ibrunat Capsule

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Ibrutinib (140mg)

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General Information

Contains

Ibrutinib (140mg)

Marketer

Natco Pharma Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Ibrunat Capsule is taken in a dose as advised by the doctor. The duration of treatment varies on the basis of your response to treatment. Your doctor may get regular blood tests to check number of blood cells during treatment with this medicine. It is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. It may cause headache, diarrhea, and nausea as its side effects.

Uses of Ibrunat Capsule

Benefits of Ibrunat Capsule

Blood cancer (Chronic lymphocytic leukemia)
Chronic lymphocytic leukemia (CLL) is a slow-growing blood cancer in which the bone marrow makes abnormal white blood cells that crowd out healthy cells and weaken the immune system. Ibrunat Capsule helps block signals that cancer cells need to grow and multiply, slowing disease progression and supporting healthier blood cell balance. This helps manage symptoms, maintain immune function, and improve quality of life.

Mantle-cell lymphoma
Mantle-cell lymphoma is a type of non-Hodgkin lymphoma that affects lymph nodes and other parts of the lymphatic system. Ibrunat Capsule helps stop cancer cells from growing and spreading, allowing for better disease control. This can reduce symptoms, slow disease advancement, and extend periods without disease progression.

Side effects of Ibrunat Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ibrunat

Fever
Headache
Fatigue
Musculoskeletal (bone, muscle or joint) pain
Rash
Anemia (low number of red blood cells)
Bruising
Muscle spasm
Hemorrhage
Pneumonia
Cough
Diarrhea
Stomatitis (Inflammation of the mouth)
Nausea
Low blood platelets
Decreased white blood cell count (neutrophils)
Dry eye
High blood pressure
Weight loss
Urinary tract infection
Peripheral edema
Subdural hematoma
Second primary malignancies

How to use Ibrunat Capsule

Take this medicine in the dose and duration as advised by your doctor. Ibrunat Capsule may be taken with or without food.

How Ibrunat Capsule works

Ibrunat Capsule is a Bruton's tyrosine kinase inhibitor. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

All substitutes for Ibrunat Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take it at the same time every day, either with or without food.
It is advisable to stay hydrated and drink plenty of fluids while taking this medication.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your liver function and blood cell count in your blood.
Take it at the same time every day, either with or without food.
It is advisable to stay hydrated and drink plenty of fluids while taking this medication.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your liver function and blood cell count in your blood.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Ibrunat Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Ibrunat Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Ibrunat Capsule should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Ibrunat Capsule may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Ibrunat Capsule should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Ibrunat Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Ibrunat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Apalutamide (Oral Route)

Apalutamide may reduce blood levels of Ibrutinib. Apalutamide may reduce blood levels of Ibrutinib.

Severe

Clarithromycin (Oral Route)

Clarithromycin may raise blood levels of Ibrutinib. Clarithromycin may raise blood levels of Ibrutinib.

Severe

Enzalutamide (Oral Route)

Enzalutamide may reduce blood levels of Ibrutinib. Enzalutamide may reduce blood levels of Ibrutinib.

Severe

Ceritinib (Oral Route)

Ceritinib may raise blood levels of Ibrutinib. Ceritinib may raise blood levels of Ibrutinib.

Severe

Indinavir (Oral Route)

Indinavir may raise blood levels of Ibrutinib. Indinavir may raise blood levels of Ibrutinib.

Frequently asked questions

What is Ibrunat Capsule used for?

Ibrunat Capsule is used in the treatment of mantle-cell lymphoma and blood cancer (chronic lymphocytic leukemia). In patients having chronic lymphocytic leukemia, this medicine is given only if they have undergone at least one previous treatment.

Who should not take Ibrunat Capsule?

There are no absolute contraindications listed, but Ibrunat Capsule may not be suitable for everyone. Patients with severe liver disease or certain medical conditions may require dose adjustments or close monitoring. Your doctor will closely assess your condition before starting Ibrunat Capsule treatment.

What warnings of Ibrunat Capsule should I know about before starting Ibrunat Capsule?

Ibrunat Capsule can increase the risk of bleeding, infections, heart rhythm problems, high blood pressure, liver damage, and other serious side effects. Regular monitoring with blood tests and medical checkups is necessary during treatment.

Can Ibrunat Capsule cause heart problems?

Yes, Ibrunat Capsule has been linked to irregular heartbeats (arrhythmias), heart failure, and even sudden death in rare cases. Patients with a history of heart disease should inform their doctor before starting Ibrunat Capsule therapy.

Does Ibrunat Capsule increase the risk of infections?

Yes, Ibrunat Capsule can lower your body’s ability to fight infections. Patients may develop fevers, pneumonia, or other serious infections. Any sign of infection should be reported to your doctor right away.

Can Ibrunat Capsule cause bleeding or bruising?

Yes, bleeding problems such as bruising, nosebleeds, or more serious internal bleeding can happen with Ibrunat Capsule. If you are taking blood thinners or have a bleeding disorder, you must inform your doctor before starting Ibrunat Capsule.

What are the serious side effects of Ibrunat Capsule?

Serious side effects of Ibrunat Capsule include severe bleeding, life-threatening infections, liver damage, high blood pressure, heart rhythm problems, secondary cancers such as skin cancer, and tumor lysis syndrome (a complication when cancer cells break down too quickly). Seek immediate medical attention if you experience any of these symptoms.

Can Ibrunat Capsule cause liver damage?

Yes, Ibrunat Capsule has been linked to hepatotoxicity, which means it can cause liver injury. Doctors usually monitor liver function with blood tests during treatment.

Can Ibrunat Capsule cause other cancers?

Yes, some patients on Ibrunat Capsule have developed second cancers, including skin cancers and other types of carcinoma. Skin checks and regular monitoring are recommended during Ibrunat Capsule treatment.

Fact Box

Chemical Class

Diphenylethers Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Bruton's tyrosine kinase (BTK) inhibitors

Related lab tests

Complete Blood Count

Cyclin D1

Peripheral Smear Examination

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Ibrunat Capsule

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Ibrunat Capsule

Benefits of Ibrunat Capsule

Side effects of Ibrunat Capsule

How to use Ibrunat Capsule

How Ibrunat Capsule works

All substitutes for Ibrunat Capsule

Nitib 140mg Capsule

Ibrushil 140mg Capsule

Imbruvica 140mg Capsule

Ibrushil 140mg Capsule

Imbruvica 140mg Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Apalutamide (Oral Route)

Clarithromycin (Oral Route)

Enzalutamide (Oral Route)

Ceritinib (Oral Route)

Indinavir (Oral Route)

Frequently asked questions

What is Ibrunat Capsule used for?

Who should not take Ibrunat Capsule?

What warnings of Ibrunat Capsule should I know about before starting Ibrunat Capsule?

Can Ibrunat Capsule cause heart problems?

Does Ibrunat Capsule increase the risk of infections?

Can Ibrunat Capsule cause bleeding or bruising?

What are the serious side effects of Ibrunat Capsule?

Can Ibrunat Capsule cause liver damage?

Can Ibrunat Capsule cause other cancers?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Cyclin D1

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests