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Fos-Aprepitant 125mg Tablet

Aprepitant (125mg)
Genuine
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Fos-Aprepitant 125mg Tablet is a prescription medicine used to prevent nausea and vomiting caused by chemotherapy. It is also used in the prevention of postoperative nausea and vomiting in adults.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
₹1187 MRP ₹1312.510% off 
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General Information

Contains

Aprepitant (125mg)

Marketer

Fulford India Ltd

Storage

Store below 30°C
The content is shown in English
Fos-Aprepitant 125mg Tablet image
Fos-Aprepitant 125mg Tablet image

Product introduction

Fos-Aprepitant 125mg Tablet is taken with or without food in a dose and duration as advised by the doctor. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are headache, hiccups, loss of appetite, fatigue, and constipation. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine may cause diarrhea, so it is beneficial to drink plenty of fluids while taking this medicine as it may help to prevent dehydration. It may also cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Before taking this medicine, you should tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding. You should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you.

Uses of Fos-Aprepitant Tablet

  • Nausea and vomiting due to chemotherapy

Benefits of Fos-Aprepitant Tablet

Nausea and vomiting due to chemotherapy
Fos-Aprepitant 125mg Tablet is used to prevent nausea and vomiting caused by chemotherapy. It helps improve comfort during cancer treatment by blocking signals in the brain that trigger these symptoms, allowing patients to better tolerate their therapy.

Side effects of Fos-Aprepitant Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Fos-Aprepitant
  • Headache
  • Diarrhea
  • Dizziness
  • Hiccup
  • Loss of appetite
  • Fatigue
  • Constipation

How to use Fos-Aprepitant Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Fos-Aprepitant 125mg Tablet may be taken with or without food.

How Fos-Aprepitant Tablet works

Fos-Aprepitant 125mg Tablet is an antiemetic medication. It works by blocking the action of a chemical messenger (neurokinin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy).

Quick tips

  • Fos-Aprepitant 125mg Tablet helps prevent nausea and vomiting caused by certain chemotherapy medicines.
  • It will not help if you already have nausea and vomiting.
  • Do not use it continuously for a long time.
  • It is recommended to take Fos-Aprepitant 125mg Tablet 1 hour before chemotherapy treatment (Day 1) and in the morning on Days 2 and 3.
  • It may damage sperms and may harm the baby if used during pregnancy or breastfeeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Fos-Aprepitant 125mg Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Fos-Aprepitant 125mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Fos-Aprepitant 125mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Fos-Aprepitant 125mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Fos-Aprepitant 125mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

SAFE IF PRESCRIBED
Fos-Aprepitant 125mg Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Fos-Aprepitant with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Pimozide (Oral Route)

Do not consume Aprepitant with Pimozide.
Life-threatening

Primidone (Oral Route)

Do not consume Aprepitant with Primidone. Primidone may reduce blood levels of Aprepitant.
Severe

Ranolazine (Oral Route)

Watch out for symptoms of Aprepitant side effects such as nausea, vomiting, headache, dizziness, constipation or weakness and consult your doctor if you experience them. They may adjust the dose of Aprepitant accordingly. Aprepitant may raise blood levels of Ranolazine.
Severe

Apalutamide (Oral Route)

Concomitant use should be avoided. Please consult with your doctor. Apalutamide may increase the metabolism of Aprepitant.
Severe

Carbamazepine (Oral Route)

Do not consume Aprepitant with Carbamazepine. Carbamazepine may reduce blood levels of Aprepitant.

Frequently asked questions

Fos-Aprepitant 125mg Tablet is used in adults in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (cancer treatment) or in some cases after a surgery
Fos-Aprepitant 125mg Tablet is an antiemetic that works by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.

Fact Box

Chemical Class

Phenylmorpholines

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Neurokinin-1 (NK1) Receptor Antagonists

References

  1. McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1086.
  2. Aprepitant. [Accessed 28 Mar. 2019] (online) Available from:
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Fulford India Ltd
Address: Plot No. -810, Sector - 3 , Industrial Area , Pthampur Dist. Dhar - 454 775 (M.P.) India

Vendor Details

Country of origin: India

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