Flexifree-D Injection

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Flexifree-D Injection is a pain-relieving medicine. It is used to treat various types of pain, swelling, stiffness, and joint pain in conditions like rheumatoid arthritis, osteoarthritis, and acute musculoskeletal injuries. It is given in cases where oral administration is not possible.

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Flexifree-D Injection

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Diclofenac (75mg/ml)

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General Information

Contains

Diclofenac (75mg/ml)

Marketer

Ghrelin Pharmaceuticals Private Limited

Storage

Store below 25°C

The content is shown in English

Product introduction

Flexifree-D Injection is generally administered by a doctor or a nurse. Do not self-administer this medicine at home. Inform your doctor if you have any history of heart disease or stroke. Consult your doctor in case any injection site reactions like pain, swelling, or redness are observed.

The most common side effects of this medicine include nausea, vomiting, headache, and injection site reactions. Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment. Long-term use may lead to serious complications such as stomach bleeding and kidney problems.

Uses of Flexifree-D Injection

Pain relief

Benefits of Flexifree-D Injection

Pain relief
Flexifree-D Injection belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis.

Take it as it is prescribed to get the most benefit. Do not take more or longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Flexifree-D Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Flexifree-D

Diarrhea
Flatulence
Vomiting
Injection site reactions (pain, swelling, redness)
Headache
Dizziness
Nausea
Insomnia (difficulty in sleeping)
Constipation
Abdominal pain
Dyspepsia
Gastrointestinal bleeding
Gastrointestinal ulcer
Rash
Application site irritation
Injection site pain

How to use Flexifree-D Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Flexifree-D Injection works

Flexifree-D Injection is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).

All substitutes for Flexifree-D Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed Flexifree-D Injection to relieve pain and inflammation.
Long-term use may lead to serious complications such as stomach bleeding and kidney problems.
It may cause dizziness, drowsiness, or visual disturbances. Use caution while driving or doing anything that requires concentration.
Avoid consuming alcohol while taking Flexifree-D Injection as it can cause excessive drowsiness and increase your risk of stomach problems.
Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Flexifree-D Injection.

Pregnancy

CONSULT YOUR DOCTOR

Flexifree-D Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Flexifree-D Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Flexifree-D Injection may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Flexifree-D Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Flexifree-D Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Flexifree-D with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Fondaparinux (Injection Route)

If concurrent use is essential, watch out for bleeding and consult your doctor immediately.

Severe

Heparin (Injection Route)

Do not consume Diclofenac with Heparin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Diclofenac may increase the effect of Heparin.

Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.

Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Frequently asked questions

How should Flexifree-D Injection be administered?

Flexifree-D Injection should only be given by a healthcare professional. It can be given deep into the muscle (intramuscularly), preferably in the buttock, under the skin (subcutaneously), or directly into a vein (intravenously) as a bolus and not as an infusion. The dose should not exceed the prescribed quantity and injection should not be given for more than 2 days.

What is the most important information I need to know about Flexifree-D Injection?

It is important to know that Flexifree-D Injection may increase your chance of having a heart attack or stroke. The risk is higher if you take higher doses and have used the medicine for a long time. Additionally, Flexifree-D Injection may cause ulcers, bleeding, or holes in your stomach and intestine. If you experience any such problems, consult your doctor immediately.

Is Flexifree-D Injection a good painkiller?

Flexifree-D Injection is effective in relieving pain and inflammation. It is used for various sorts of pain such as sprains, strains, and other injuries. It is also helpful in various types of arthritis, gout, pain, and inflammation following surgery.

Can Flexifree-D Injection hurt your kidneys?

Long-term use and high doses of Flexifree-D Injection may cause renal problems such as protein or blood in urine and painful urination. Patients who are at maximum risk of developing kidney problems include dehydrated people, individuals with heart failure, impaired kidney function, hypertension, and the elderly. Hence, for such patients kidney function monitoring is recommended.

Is Flexifree-D Injection a good painkiller?

Flexifree-D Injection is effective in relieving pain and inflammation. It is used for various sorts of pain such as sprains, strains and other injuries. It is also helpful in various types of arthritis, gout, pain and inflammation following surgery.

Is Flexifree-D Injection a narcotic?

No, Flexifree-D Injection is not a narcotic. It belongs to non-steroidal anti-inflammatory drugs (NSAIDs) group of medicines.

Does Flexifree-D Injection get you high?

No, Flexifree-D Injection does not get you high. It does not have an abuse potential (drug-seeking behavior) and does not cause physical or psychological dependence. However, if you do not feel well, consult your doctor.

Can Flexifree-D Injection damage your kidneys?

Long-term use and high doses of Flexifree-D Injection may cause renal problems such as protein or blood in urine and painful urination. Patients who are at maximum risk of developing kidney problems include people who are dehydrated, have heart failure, impaired kidney function, hypertension, elderly, who are on medicines which cause excess urination (diuretics), or medicines which have significant impact on kidney function. Hence, for such patients kidney function monitoring is recommended.

Does Flexifree-D Injection make you drowsy?

Flexifree-D Injection can cause drowsiness and also dizziness, fatigue (tiredness) and visual disturbances. However, it is not very common and may not affect everyone. If you experience these symptoms avoid driving or operating heavy machinery.

What is the most important information I need to know about Flexifree-D Injection?

It is important to know that Flexifree-D Injection may increase your chance of having a heart attack or stroke. The risk is more if you take higher doses and have been using the medicine for a longer time. Also, taking Flexifree-D Injection may cause ulcers, bleeding, or holes in your stomach and intestine. These problems may happen without warning symptoms at any time during treatment and may even cause death. Therefore, if you encounter any such problems, consult your doctor immediately.

Can Flexifree-D Injection be taken during pregnancy?

You should not take Flexifree-D Injection during the last 3 months of pregnancy as it may cause harmful effects on your baby. Use of Flexifree-D Injection can also lead to reduced labor (premature delivery). Hence, it is advised to avoid using Flexifree-D Injection during the first 6 months of pregnancy also. In some cases, Flexifree-D Injection may be prescribed in pregnant women only if the benefits outweigh the risks involved with its use in pregnant women. If not sure, consult your doctor regarding its use.

Fact Box

Chemical Class

Dichlorobenzenes

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid)

References

Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 626.
Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 986-87.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 295-97.
Diclofenac. Dublin 2, Republic of Ireland: Flynn Pharma Ltd.; 2017. [Accessed 02 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
Diclofenac [Prescribing Information]. Lake Forest, IL: Hospira, Inc.; 2014. [Accessed 06 Apr. 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ghrelin Pharmaceuticals Private Limited
Address: Suja Apt, Flat No. 204,D. P Link Road Ic Coliny, Silver Coin Hotel,Boriwali(W) Mumbai Mumbai City Mh 400103 India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Flexifree-D Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Flexifree-D Injection

Benefits of Flexifree-D Injection

Side effects of Flexifree-D Injection

How to use Flexifree-D Injection

How Flexifree-D Injection works

All substitutes for Flexifree-D Injection

Dyact-AQ Injection

3 Flam Aqua Injection

Aynagesic-AQ Injection

Unidic-AQ Injection

Pulsonac-AQ Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Fondaparinux (Injection Route)

Heparin (Injection Route)

Tacrolimus (Oral Route)

Methotrexate (Injection Route)

Methotrexate (Injection Route)

Frequently asked questions

How should Flexifree-D Injection be administered?

What is the most important information I need to know about Flexifree-D Injection?

Is Flexifree-D Injection a good painkiller?

Can Flexifree-D Injection hurt your kidneys?

Is Flexifree-D Injection a good painkiller?

Is Flexifree-D Injection a narcotic?

Does Flexifree-D Injection get you high?

Can Flexifree-D Injection damage your kidneys?

Does Flexifree-D Injection make you drowsy?

What is the most important information I need to know about Flexifree-D Injection?

Can Flexifree-D Injection be taken during pregnancy?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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